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疾病领域	数量

免疫系统疾病	1

排名前五的药物类型	数量

化学药	1

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1

项与 OsteoBiologics, Inc. 相关的药物

BT-002(Osteo Pharma)

靶点-

作用机制-

在研机构

OsteoBiologics, Inc.

原研机构

Osteo-Pharma BV初创企业

在研适应症

骨病 [+2]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 OsteoBiologics, Inc. 相关的临床结果

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0 项与 OsteoBiologics, Inc. 相关的专利（医药）

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12

项与 OsteoBiologics, Inc. 相关的文献（医药）

2003-12-01·Arthritis & Rheumatism

Indentation testing of human cartilage: Sensitivity to articular surface degeneration

Article

作者: Gabriele G. Niederauer ; David Amiel ; Won C. Bae ; Robert L. Sah ; Richard D. Coutts ; Michele M. Temple

AbstractObjectiveTo determine, for clinical indentation testing of human articular cartilage, the effects of aging and degeneration on indentation stiffness and traditional indices of cartilage degeneration; the relationship between indentation stiffness and indices of degeneration; and the sensitivity and specificity of indentation stiffness to cartilage degeneration.MethodsOsteochondral cores from femoral condyles of cadaveric human donors were harvested. Samples were distributed into experimental groups based on donor age (young [20–39 years], middle [40–59 years], and old [≥60 years]), and a macroscopic articular surface appearance that was either normal or mildly degenerate, without deep erosion. Samples were analyzed for indentation stiffness, cartilage thickness, India ink staining (quantitated as the reflected light score), and Mankin‐Shapiro histopathology score.ResultsIndentation stiffness, India ink staining, and the histopathology score each varied markedly between normal‐sample and degenerate‐sample groups but varied relatively little between normal samples obtained from different age groups. A decrease in indentation stiffness (softening) correlated with a decrease in the reflectance score and an increase in the overall histopathology score, especially the surface irregularity component of the histopathology score. Receiver operating characteristic analysis suggested that the indentation testing could accurately detect cartilage degeneration as indicated by macroscopic appearance, India ink staining, and histopathology score.ConclusionThe indentation stiffness of the normal to mildly degenerate samples tested in this study was sensitive to mild degeneration at the articular surface and was insensitive to changes associated with normal aging or to slight variations in cartilage thickness. This suggests that indentation testing may be a useful clinical tool for the evaluation of early‐stage degenerative changes in articular cartilage.

2002-01-01·Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology

Sensitivity of a hand-held indentation Probe for measuring the stiffness of articular cartilage

作者: K.A. Athanasiou ; G.M. Niederauer ; J.B. Thomas ; M.Q. Niederauer ; G.G. Niederauer ; L.C. Cullen

The in vivo assessment of the quality of cartilage is a critical tool to determine how to clinically treat damaged cartilage. Utilizing non-destructive indentation, a hand-held instrument (ACTAEON/spl trade/ Probe) can be used to rapidly measure the stiffness of articular cartilage, which can then be correlated to cartilage condition. The engineering design aspects of the instrument and the feasibility testing which have been undertaken using both animal and human knee joints are presented. An integrated series of tests were performed to determine whether the Probe is sensitive enough to detect early degenerative changes in articular cartilage and to examine if it is dependent on the thickness of the cartilage being tested. Results demonstrated that there is no effect of thickness on the Probe measurements, that the Probe is sensitive enough to detect different levels of cartilage degeneration, and that Probe data correlate well with traditional creep indentation testing. This study demonstrates the utility of the Probe for detecting degenerative changes in animal and human joints.

2001-12-01·Tissue Engineering

Porous, Resorbable, Fiber-Reinforced Scaffolds Tailored for Articular Cartilage Repair

Article

作者: Slivka, Michael A. ; Leatherbury, Neil C. ; Kieswetter, Kris ; Niederauer, Gabriele G.

Porous 75:25 poly(D,L-lactide-co-glycolide) scaffolds reinforced with polyglycolide fibers were prepared with mechanical properties tailored for use in articular cartilage repair. Compression testing was performed to investigate the influence of physiological testing conditions, manufacturing method, anisotropic properties due to predominant fiber orientation, amounts of fiber reinforcement (0 to 20 wt, %), and viscoelasticity via a range of strain rates. Using the same testing modality, the mechanical properties of the scaffolds were compared with pig and goat articular cartilage. Results showed that mechanical properties of the scaffolds under physiological conditions (aqueous, 37 degrees C) were much lower than when tested under ambient conditions. The manufacturing method and anisotropy of the scaffolds significantly influenced the mechanical properties. The compressive modulus and yield strength proportionally increased with increasing fiber reinforcement up to 20%. From 0.01 to 10 mm/mm/min strain rate, the compressive modulus increased in a logarithmic fashion, and the yield strength increased in a semi-log fashion. The compressive modulus of the non-reinforced scaffolds was most similar to the pig and goat articular cartilage when compared using similar testing conditions and modality, but the improvement in yield strength using the stiffer scaffolds with fiber reinforcement could provide needed structural support for in vivo loads.

100 项与 OsteoBiologics, Inc. 相关的药物交易

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100 项与 OsteoBiologics, Inc. 相关的转化医学

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