Delving into the Latest Updates on Universidade Federal De Alfenas with Synapse

概览

疾病领域	数量

神经系统疾病	4
内分泌与代谢疾病	1

排名前五的药物类型	数量

化学药	3
小分子化药	1

关联

4

项与 Universidade Federal De Alfenas 相关的药物

LASSBio-776

靶点-

作用机制-

在研机构

Universidade Federal De Alfenas

原研机构

Federal University of Rio de Janeiro

在研适应症

炎症 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

LASSBio-755

靶点-

作用机制-

在研机构

Universidade Federal De Alfenas

原研机构

Universidade Federal De Alfenas

在研适应症

疼痛

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

PQM-164

靶点-

作用机制-

在研机构

Universidade Federal De Alfenas

原研机构

Universidade Federal De Alfenas

在研适应症

帕金森病

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

72

项与 Universidade Federal De Alfenas 相关的临床试验

RBR-2rsmbsf / Not yet recruitingN/AIIT

The effects of a Zumba Dance and Mat Pilates protocol in women post Breast Cancer Surgery

开始日期2024-09-30

申办/合作机构

Universidade Federal De Alfenas

[+1]

RBR-863c6dk / RecruitingN/AIIT

Analysis of the prevalence of injuries and cardiorespiratory fitness in amateur athletes and development of a preventive protocol

开始日期2024-03-14

申办/合作机构

Universidade Federal De Alfenas

[+1]

RBR-8g8ckzm / RecruitingN/AIIT

Effect of Peripheral Magnetic Stimulation on postoperative pain control of foot and ankle surgery - clinical, controlled, randomized trial

开始日期2024-02-01

申办/合作机构

Universidade Federal De Alfenas

[+1]

100 项与 Universidade Federal De Alfenas 相关的临床结果

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0 项与 Universidade Federal De Alfenas 相关的专利（医药）

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5,292

项与 Universidade Federal De Alfenas 相关的文献（医药）

2024-11-01·Nutrition

Consumption of processed meat but not red meat is associated with the incidence of hypertension: ELSA-Brasil cohort

Article

作者: Mendes, Michelle Izabel Ferreira ; Aprelini, Carla Moronari de Oliveira ; Molina, Maria del Carmen Bisi ; Molina, Maria Del Carmen Bisi ; Mendonça, Raquel de Deus

OBJECTIVESTo verify the association between the consumption of red and processed meats and the incidence of hypertension in participants of the Longitudinal Study of Adult Health.METHODSThis was a cohort with data from the baseline (2008-2010) and second wave (2012-2014) with 8,089 public workers of both sexes and different racial groups, with mean age of 49 ± 8 years (35-74 years old). Meat consumption (g/d) was estimated using a food frequency questionnaire and was divided into consumption tertiles. Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic ≥90 mm Hg and/or antihypertensive medication. Cox proportional hazards models were used to estimate adjusted Hazard Ration (HRs) and 95% confidence interval (CI) for incident hypertension.RESULTSA total of 1186 incident cases of hypertension were identified. Even adjusting for confounders, such as urinary Na/K (sodium/potassium) ratio and BMI (body mass index), participants in the second (HR:1.19; 95% CI 1.03-1.30) and third (HR:1.30; 95% CI:1.11-1.53) tertile of processed meat consumption had a higher risk of developing hypertension than those in the first tertile. We did not find a significant association between red meat consumption and hypertension.CONCLUSIONSThe increased risk of developing hypertension is associated with moderate and high consumption of processed meats but not with consumption of red meat.

2024-11-01·Naunyn-Schmiedeberg's Archives of Pharmacology

Safety of metamizole (dipyrone) for the treatment of mild to moderate pain—an overview of systematic reviews

Review

作者: Podestá, Márcia Helena Miranda Cardoso ; Veronezi, Rafael Nakano ; Torres, Larissa Helena ; Eleutério, Larissa Porto ; Eleutério, Otávio Henrique Porto ; Rascado, Ricardo Radighieri ; Dos Reis, Tiago Marques ; Marrafon, Danielle Aparecida Ferreira de Oliveira ; Martinez-Sobalvarro, Joselin Valeska

Metamizole, as known as dipyrone or novaminsulfone is widely used, especially in Latin America, for its analgesic and antipyretic function. However, several countries have banned it due to the risk of agranulocytosis, skin necrosis, and other serious adverse effects. To assess the safety of metamizole compared to other commonly used non-opioid analgesics (paracetamol, ibuprofen, and acetylsalicylic acid). An overview of systematic reviews. The searches were performed in the PubMed, Cochrane Library, Embase, Scopus and LILACS databases. Systematic reviews of randomized and nonrandomized clinical trials with adult patients with mild to moderate pain that assessed the adverse effects of metamizole were included. A methodological quality assessment was performed through ROBIS. The protocol of this systematic review was submitted to the International Prospective Register of Systematic Reviews (Prospero, CRD42021295272). Of 387 identified studies, four were included, with a total of 20,643 participants, all submitted to a single dose by oral, intramuscular, or intravenous route. No study reported a serious adverse effect. However, 60 of 778 patients (7.7%) who used metamizole; 120/828 (14.5%) who used acetylsalicylic acid; 56/443 (12.6%) who used paracetamol; and 27/213 (12.7%) who used ibuprofen had mild adverse effects. A complementary statistical analysis showed that metamizole, at any dose, has a 38.8% lower chance of adverse effects compared to paracetamol and 46.8% compared to acetylsalicylic acid. The results shows that metamizole is a safe drug with evidence of a lower incidence of adverse effects compared to paracetamol and acetylsalicylic acid.

2024-11-01·International Journal of Biological Macromolecules

Interaction between modified magnetic nanoparticles and human albumin: Kinetics and isotherm studies and application in protein depletion

Article

作者: de Carvalho, Diailison Teixeira ; Figueiredo, Eduardo Costa ; Gorup, Luiz Fernando ; Hirata, Daniela Bataglia ; Santos, Mariane Gonçalves

Magnetic nanoparticles modified with tetraethyl orthosilicate (Fe₃O₄@TEOS) and bovine serum albumin (Fe₃O₄@TEOS@BSA) were evaluated as sorbent in albumin depletion from human serum samples by magnetic dispersive solid phase extraction. Characterization studies were carried out by X-ray diffraction, thermogravimetry, Fourier transform infrared spectroscopy, zeta potential, and scanning electron microscopy. Both nanoparticles also showed high thermal stability and pH-dependent surface charges. The human serum albumin adsorption protocol was optimized using a central composite rotatable design. Nanoparticle mass, pH, and albumin concentration were the most influential variables. Avrami's fractional order and Freundlich isotherm models best fitted the data for human albumin adsorption kinetic and isotherm studies for Fe₃O₄@TEOS and Fe₃O₄@TEOS@BSA, and the maximum adsorption capacities were 11.93 and 14.89 mg g^-1, respectively. The protein desorption was influenced by the pH of samples and eluent volume. Electrophoresis in a polyacrylamide gel containing sodium dodecyl sulfate showed different patterns of serum protein bands when consecutive depletions were performed. The Fe₃O₄@TEOS showed greater affinity for HSA and efficiency in depletion. The process was versatile, and the depleted albumin proportion could be controlled by the nanoparticle masses. The proposed method is a powerful sample preparation technique for rapid, reliable, and specific depletion of albumin.

100 项与 Universidade Federal De Alfenas 相关的药物交易

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100 项与 Universidade Federal De Alfenas 相关的转化医学

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