Delving into the Latest Updates on Tokyo Metropolitan Institute of Medical Science with Synapse

Restoration of brain function via artificial neural connection - Restoration of locomotor function via artificial neural connection in individuals with spinal cord injury

开始日期2017-04-01

申办/合作机构

Tokyo Metropolitan Institute of Medical Science

JPRN-UMIN000021966 / Completed

Project for Promotion of Community Care Program for People Living With Dementia - Development of Japanese version of BPSD Program of Care

开始日期2016-09-01

申办/合作机构

Tokyo Metropolitan Institute of Medical Science

JPRN-UMIN000023742 / Unknown statusN/AIIT

Study of factors of virus and host sassociated with severe Enterovirus diseases - Study of severe Enterovirus diseases

开始日期2016-07-01

申办/合作机构

Tokyo Metropolitan Institute of Medical Science

100 项与 Tokyo Metropolitan Institute of Medical Science 相关的临床结果

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0 项与 Tokyo Metropolitan Institute of Medical Science 相关的专利（医药）

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2,830

项与 Tokyo Metropolitan Institute of Medical Science 相关的文献（医药）

2025-03-01·Neural Regeneration Research

Monogenic gene therapy for glaucoma and optic nerve injury

Article

作者: Harada, Chikako ; Harada, Takayuki ; Guo, Xiaoli

2024-12-01·eNeurologicalSci

Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation

Article

作者: Arakawa, Akira ; Takeda, Katsuhiko ; Tokumaru, Aya Midori ; Kurihara, Masanori ; Eguchi, Hiroto ; Hasegawa, Masato ; Murayama, Shigeo ; Shimo, Yasushi ; Matsubara, Tomoyasu ; Saito, Yuko ; Kanemaru, Kazutomi ; Iwata, Atsushi

A 72-year-old man presented with a 6-month history of decreased voluntary speech. Sparse speech and decreased word fluency were observed. Articulation, naming, comprehension, and repetition were preserved. Agrammatism and paraphasia were not observed. These characteristics matched those reported as dynamic aphasia. Other findings were mild behavioral symptoms, recent memory impairment, and right hemiparkinsonism. The patient's voluntary speech continued to reduce and behavioral symptoms progressed. Brain MRI including voxel-based morphometric analysis showed left-dominant white matter volume reduction in the frontal lobe including those between the left supplementary motor area (SMA)/preSMA and the frontal operculum, likely involving the frontal aslant tract (FAT). The patient became completely mute after two years from disease onset and died of aspiration pneumonia. The neuropathological diagnosis was corticobasal degeneration (CBD). This case suggests that dynamic aphasia may be the initial sign of CBD and that early involvement of left FAT may be responsible for this feature.

2024-11-01·Journal of the Neurological Sciences

Long-standing preservation of levodopa response in progressive supranuclear palsy

Article

作者: Takahashi, Yuji ; Sano, Terunori ; Hara, Norikazu ; Ikeuchi, Takeshi ; Miyashita, Akinori ; Hasegawa, Masato ; Takao, Masaki ; Ishihara, Tasuku ; Mizutani, Masashi

The clinical and neuropathological characteristics of progressive supranuclear palsy (PSP) with preservation of levodopa (L-dopa) response are described in this report. We present the case of a 73-year-old Japanese man with a 13-year history of dopa-responsive Parkinsonism and abnormalities observed in metaiodobenzylguanidine (MIBG) myocardial scintigraphy, suggesting Parkinson's disease. However, autopsy results revealed PSP pathology, including tuft-shaped astrocytes and globose-type neurofibrillary tangles, without Lewy body pathology. The degeneration was moderately to severely distributed in the globus pallidus, subthalamic nucleus, and substantia nigra, whereas striatal degeneration was mild. These findings suggest an intact response to L-dopa therapy throughout the patient's lifetime. Pathological examination of cardiac sympathetic nerves revealed intact nerves, suggesting functional involvement in the MIBG abnormality. This study provides further evidence of the clinical and pathological heterogeneity of PSP. Homozygosity for both the rs564309-C allele at TRIM11 and the rs2242367-G allele at SLC2A13 might have played a protective role. This case indicates a protracted course-PSP, which may hold promise for future treatments.

100 项与 Tokyo Metropolitan Institute of Medical Science 相关的药物交易

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100 项与 Tokyo Metropolitan Institute of Medical Science 相关的转化医学

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