Delving into the Latest Updates on Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry with Synapse

概览

疾病领域	数量

肿瘤	1
免疫系统疾病	1
神经系统疾病	1

排名前五的药物类型	数量

融合蛋白	1
重组多肽	1

排名前五的靶点	数量

DR5 x VEGFR2	1

关联

2

项与 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 相关的药物

Myelopidum

靶点-

作用机制

免疫调节剂

在研机构

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

原研机构

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

在研适应症

免疫缺陷综合征

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

俄罗斯

首次获批日期1995-02-01

SRH-DR5-B-iRGD

靶点

DR5 x VEGFR2

作用机制

DR5调节剂 [+1]

在研机构

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry [+1]

原研机构

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry [+1]

在研适应症

胶质母细胞瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

1

项与 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 相关的临床试验

NCT06386653

/ Completed临床1期IIT

SPECT Imaging of EpCAM Receptors Using [123I]I-DARPIN-Ec1 in Lung and Ovarian Cancers Patients

The study should evaluate the biological distribution of [123I]I-DARPIN-Ec1 in patients with lung and ovarian cancer
The primary objective are:
1. To assess the distribution of [123I]I-DARPIN-Ec1 in normal tissues and tumors at different time intervals.
2. To evaluate dosimetry of [123I]I-DARPIN-Ec1.
3. To study the safety and tolerability of the drug [123I]I-DARPIN-Ec1 after a single injection in a diagnostic dosage.
The secondary objective are:
1. To compare the obtained [123I]I-DARPIN-Ec1 SPECT imaging results with the data of CT and/or MRI and/or ultrasound examination and immunohistochemical (IHC) studies in lung and ovarian cancer patients.

开始日期2024-04-14

申办/合作机构

Tomsk National Research Medical Center of the Russian Academy of Sciences

[+2]

100 项与 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 相关的临床结果

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0 项与 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 相关的专利（医药）

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2,741

项与 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 相关的文献（医药）

2025-08-01·Neuropharmacology

The major component of Heteractis magnifica sea anemone venom, RpIII, exhibits strong subtype selectivity for insects over mammalian voltage-gated sodium channels

Article

作者: Sintsova, Oksana ; Otstavnykh, Nadezhda ; Kalina, Rimma ; Shamatova, Margarita ; Priymenko, Nadezhda ; Kozlov, Sergey ; Pavlenko, Aleksandra ; Isaeva, Marina ; Leychenko, Elena ; Tytgat, Jan ; Peigneur, Steve ; Gladkikh, Irina ; Garbuz, Mikhail ; Klimovich, Anna

Voltage-gated sodium channels (Na_V) are molecular targets for the development of drugs for the treatment of diseases such as epilepsy, neuropathic pain, long QT syndrome, etc., as well as for insecticides. Therefore, the search for novel selective Na_V channel ligands is relevant. Using amplicon deep sequencing of tentacle cDNA libraries from sea anemones Heteractis magnifica, 36 transcripts related to RpIII neurotoxin, a Na_V channel modulators, were revealed. The recombinant RpIII was moderately toxic for mice (LD₅₀ 0.030 ± 0.004 mg/kg) but did not demonstrate any activity towards Na_V in human SH-SY5Y cells. The toxin inhibited inactivation of heterologously expressed mammalian, insect, and arachnid Na_V channels with higher specificity to insect channels. Cockroach (Blattella germanica) sodium channel BgNa_V1 (EC₅₀ of 2.4 ± 0.2 nM) and yellow fever mosquito (Aedes aegypti) channel AaNa_V1 (EC₅₀ of 1.5 ± 0.3 nM) were the most sensitive to RpIII, while mammals Na_V had EC₅₀ values above 100 nM except mNa_V1.6 (EC₅₀ of 43.8 ± 3.6 nM). The low nanomolar RpIII affinity to insect AaNa_V1 may be explained by the extensive intermolecular contacts found by docking study. According to the predicted data, the toxin lands on the ion channel between voltage-sensing domain IV and pore domain I, also known as toxin site 3, followed by stabilizing the channels in the open state what was measured at electrophysiological experiments.

2025-07-01·Genes & Diseases

Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II

Article

作者: Ishina, Irina A ; Nasonov, Evgeniy L ; Ovchinnikova, Leyla A ; Davydov, Alexey N ; Zhang, Hongkai ; Lila, Alexander M ; Nurbaeva, Kamila S ; Nersisyan, Stepan A ; Gabibov, Alexander G ; Zhbanova, Elizaveta S ; Mamedov, Azad E ; Petrusenko, Yunna S ; Ziganshin, Rustam H ; Lisitsyna, Tatiana A ; Nikonova, Anastasia V ; Mamedov, Ilgar Z ; Lomakin, Yakov A ; Salnikova, Maria A ; Kurbatskaia, Inna N ; Rubtsov, Yury P ; Zakharova, Maria Y ; Zhiyanov, Anton P ; Reshetnyak, Tatiana M ; Tonevitskiy, Alexander G ; Belogurov, Alexey A ; Eliseev, Igor E

2025-07-01·Biochimie

Divergent ferroptotic pathways in breast cancer cells: IGFBP6-regulated mitochondrial lipid peroxidation under erastin and omega-3 DHA treatment

Article

作者: Olkhovik, Darya ; Kulagin, Timur ; Fatkulin, Artem ; Klycheva, Karina ; Tonevitsky, Alexander ; Razumovskaya, Alexandra ; Nikulin, Sergey ; Averinskaya, Darya ; Silkina, Mariia ; Kolodeeva, Olga ; Kolodeeva, Oksana

Breast cancer remains a major challenge and new therapeutic approaches are needed for its treatment. Ferroptosis is considered a promising alternative cell death mechanism to eliminate resistant cancer cells. In previous works, we identified that lower IGFBP6 gene expression in tumor tissue corresponds to a worse prognosis for breast cancer patients and, at the same, time makes them more sensitive to ferroptosis. In this study, we further investigated the mechanism of ferroptosis induction in IGFBP6 knockdown and control MDA-MB-231 breast cancer cells by the canonical ferroptosis inducer erastin and omega-3 docosahexaenoic acid (DHA). Our results indicate that there is a significant overlap between the mechanisms of action of both of these molecules, as they regulate the same subset of genes, and their action can be inhibited by canonical ferroptosis inhibitors. On the other hand, we also observed significant differences between the effects of erastin and DHA. The most notable of these are the additional activation of apoptosis-related genes by DHA and its minor peroxidation of mitochondrial lipid membranes. Interestingly, our kinetic analysis of ferroptosis induction showed that IGFBP6 knockdown cells began to die earlier and could hardly be rescued from erastin-induced ferroptosis by mitochondrial antioxidant SkQ1, in contrast to control cells. Overall, our data suggest that the action of DHA is less dependent on mitochondrial membrane peroxidation during ferroptosis induction, and this molecule can be a promising candidate for the treatment of breast cancer, especially in the case of reduced IGFBP6 gene expression in cancer cells.

100 项与 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 相关的药物交易

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100 项与 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry 相关的转化医学

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