Delving into the Latest Updates on Johnson & Johnson-Merck Consumer Pharmaceuticals Co. with Synapse

概览

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

SCNA(电压门控钠通道α亚基家族)	1

关联

1

项与 Johnson & Johnson-Merck Consumer Pharmaceuticals Co. 相关的药物

Carraghenates/Titanium dioxide/zinc oxide/Lidocaine

角菜酸酯/二氧化钛/氧化锌/利多卡因

靶点

SCNA

作用机制

SCNA调节剂

在研机构

Johnson & Johnson-Merck Consumer Pharmaceuticals Co.

原研机构

Johnson & Johnson-Merck Consumer Pharmaceuticals Co.

在研适应症

出血 [+2]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

中国

首次获批日期2000-10-24

100 项与 Johnson & Johnson-Merck Consumer Pharmaceuticals Co. 相关的临床结果

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0 项与 Johnson & Johnson-Merck Consumer Pharmaceuticals Co. 相关的专利（医药）

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1

项与 Johnson & Johnson-Merck Consumer Pharmaceuticals Co. 相关的文献（医药）

1998-03-01·American Journal of Therapeutics4区 · 医学

Onset and Magnitude of Antisecretory Action Within the First 2 Hours After Administration

4区 · 医学

Article

作者: Houle, J M ; Pierce, C H ; Decktor, D

The introduction of over-the-counter histamine2 -receptor antagonists (H2 -RAs) makes it important to characterize these agents in terms of their different times to onset of action and magnitude of effect. The time to onset of action and the degree of gastric acid inhibition of the H2 -RAs famotidine and cimetidine at dosage levels approved for over-the-counter use (10 mg famotidine and 200 mg cimetidine) were compared. Twenty-four subjects with a history of heartburn of at least 2 months duration received 10 mg famotidine, 200 mg cimetidine, or placebo in a randomly assigned sequence of three treatment periods. Each period began with an overnight fast, followed by insertion of an intragastric pH probe during a 1-hour baseline monitoring phase, and, 1 hour later, administration of the test medications and monitoring of intragastric pH for an additional 2-hour period. The onset of acid inhibition occurred approximately 35 minutes after administration of either famotidine or cimetidine. Famotidine provided a significantly greater degree of efficacy on all three parameters monitored: percentage of time that gastric pH values were greater than 3.0, mean area-under-the-pH-curve-versus-time curve, and median pH (obtained at 5-minute intervals). Clearly, the over-the-counter dosage of famotidine (10 mg) provided gastric pH elevations that were as rapid and of superior degree than those induced by cimetidine 200 mg.

100 项与 Johnson & Johnson-Merck Consumer Pharmaceuticals Co. 相关的药物交易

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100 项与 Johnson & Johnson-Merck Consumer Pharmaceuticals Co. 相关的转化医学

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