Shree Vile Parle Kelavni Mandal

Aim- To develop and evaluate topical gel containing Betamethasone Dipropionate-loaded nanostructured lipid carriers for the management of Atopic dermatitis. Background- Atopic dermatitis is a chronic, recurrent skin inflammatory condition that affects both children and adults. Betamethasone Dipropionate, a commonly used topical corticosteroid, has limitations such as low bioavailability, inadequate penetration, and potential skin irritation. Objective- To evaluate the nanostructured lipid carriers gel by comparison with its marketed formulation and to improve epidermal targeting and minimize the side effects associated with the conventional formulation of betamethasone dipropionate. Method- A hot homogenization process was used to create the NLCs, and their particle size, zeta potential, entrapment efficiency, and in-vitro release were all measured. Next, the NLCs were mixed with 0.1% jojoba oil to create a gel. Results- The optimized formulation of Betamethasone dipropionate nanostructured lipid carriers had a particle size of 164 nm, PDI 0.188, zeta potential of -11.6 mv, entrapment efficiency of 92.65%, and an in-vitro release of 90.62% after 12 hours. 0.1% jojoba oil was added to the improved recipe to increase the moisturizing effect and integrated into the gel. NLC mixed in Jojoba oil gel demonstrated much higher spreadability, occlusive action, and regulated release of 91.28% after 12 hours when compared to the marketed gel. The ex-vivo investigation on porcine ear skin demonstrated enhanced penetration and retention of Betamethasone dipropionate in skin layers. There was no sign of skin irritation, indicating that the topical application was safe. Conclusion- The results of the cytotoxicity study (MTT assay) suggested NLC dispersion has cell proliferation potency on HaCaT cells and was non-toxic. Results indicated that betamethasone dipropionate's therapeutic efficacy might be enhanced by NLC formulation.

This work deals with development of fiber reinforced nanocomposites and their gas sensing performances for ammonia and ethanol target gases. Effect of cellulose nanofibers (CNF) on gas sensing ability of newly developed composite sensors, wherein modified ZSM-5 forms work as matrices and CNF as a dispersing material, has been demonstrated. Modified forms of nano NaZSM- 5, synthesized in laboratory, are obtained via dealumination and ion exchange processes. CNF/Modified nano-ZSM-5 composite film sensors are developed by solution casting method and are characterized by XRD, FTIR, SEM, TGA and BET techniques. These films are tested for detection of ammonia and ethanol gases. Various gas sensing parameters like gas response, response /recovery time and saturation limit are determined. It is observed that the composite sensors have ability to detect ammonia and ethanol gases in low temperature range(30–35°C). Gas adsorption data indicates that sensing selectivity for ammonia over ethanol can be significantly improved by such modification. CNF/Cu-ZSM-5 (C80) CNF/Fe-ZSM-5(Fe80) composite sensors show higher affinity towards ammonia and ethanol gases respectively. It is remarkable to note that blending of CNF with various modified ZSM-5 forms results in low operating temperatures (30–35°C) compared to that for ZSM-5 (135°C) for ethanol. The developed sensors can detect both gases with a concentration as low as 1ppm. Incorporation of CNF results in reduction in response and recovery times than pure ZSM-5 sensor. These sensors have potential to be used selectively as ammonia sensors.