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38

项与 Child & Adolescent Health Service 相关的临床试验

ACTRN12624001428550

/ Not yet recruiting临床2期IIT

Dose-response study of probiotics in sick term and late preterm infants: the PRINS-2 trial

开始日期2024-12-09

申办/合作机构

Child & Adolescent Health Service

ACTRN12624000765527

/ Not yet recruiting早期临床1期IIT

Evaluating the biological activity of a single dose of encapsulated oral semaglutide in healthy adults over a period of one week.

开始日期2024-11-21

申办/合作机构

Child & Adolescent Health Service

ACTRN12624000515594

/ Not yet recruitingN/AIIT

A head-to-head non-inferiority trial of low vs standard dose multi-nut oral immunotherapy in children under 6 years old.

开始日期2024-04-29

申办/合作机构

Child & Adolescent Health Service

100 项与 Child & Adolescent Health Service 相关的临床结果

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0 项与 Child & Adolescent Health Service 相关的专利（医药）

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6,427

项与 Child & Adolescent Health Service 相关的文献（医药）

2025-08-01·Stem Cell Research

Generation of the induced pluripotent stem cell line LEIi023-A from a rod-cone dystrophy patient carrying the dominant PRPF31 c.267del variant

Article

作者: Zhang, Dan ; McLaren, Terri L ; Thompson, Jennifer A ; Huang, Di ; Lamey, Tina M ; McLenachan, Samuel ; Chen, Shang-Chih ; Chen, Fred K ; Roshandel, Danial

The human induced pluripotent stem cell line LEIi023-A was generated from a 51-year-old female patient with retinitis pigmentosa 11 (RP11) caused by a single nucleotide deletion in the PRPF31 gene, (NM 015629.3: c.267del, p.(Glu89Aspfs*11)). Reprogramming the patient dermal fibroblasts was performed using episomal plasmids expressing reprogramming factors: OCT4, SOX2, KLF4, LMYC, LIN28, p53 shRNA and miR-302/367. LEIi023-A displayed expression of pluripotent stem cell markers, a normal karyotype and capability for differentiation of the three germ layers and retinal pigment epithelial cells.

2025-06-01·International Journal of Pediatric Otorhinolaryngology

Designing a paediatric teleotology pilot in the UK: Outcomes from a scoping review of the literature, with insights from the Ear Portal pilot service in Perth, Western Australia

Article

作者: Veselinović, Tamara ; Brennan-Jones, Christopher G ; Kuthubutheen, Jafri ; Bruce, Iain A ; Alenezi, Eman M A ; Saunders, Gabrielle H ; Oremule, Babatunde ; Altamimi, Ali A H ; Nichani, Jaya ; Kluk, Karolina ; Tran, Tu Trang ; Dempsey, James

OBJECTIVETo inform the design of a United Kingdom (UK) paediatric teleotology pilot by analysing global teleotology initiatives and drawing on insights from a successful paediatric teleotology pilot service in Perth, Western Australia (Ear Portal).METHODSA scoping review (January 2014-December 2024) was conducted following PRISMA-ScR guidelines (MEDLINE, Embase) to identify paediatric teleotology service designs, outcomes, and operational frameworks. Eleven studies were included, informing core criteria for a UK pilot. Additionally, a retrospective review of Ear Portal at Perth Children's Hospital (a service for children aged 6-18 years referred with ear disease) examined qualitative data from 149 participants to explore the nature of presenting complaints.RESULTSThe scoping review identified both asynchronous and synchronous service models, reporting high user satisfaction, cost-efficiency and streamlined clinical pathways. Key criteria for a UK teleotology pilot include Ear, Nose and Throat (ENT) specialist-led triage, video-otoscopy, trained facilitators, and alignment with current National Health Service (NHS) pathways. Non-otological symptoms, such as snoring (59 %) and speech issues (50 %), were frequently reported by Ear Portal participants, reinforcing the need for efficient ENT-led triage and targeted referrals.CONCLUSIONSGlobal evidence and Ear Portal data demonstrate that teleotology can improve access, efficiency, and satisfaction for paediatric ear care. Successful NHS adoption depends on robust diagnostic tools, adequately trained staff, and clear evidence of its cost-effectiveness. We propose recommendations for a UK paediatric teleotology pilot, leveraging both international evidence and real-world data.

2025-06-01·Stem Cell Research

Generation of two induced pluripotent stem cell lines carrying the CDH23 c.1515-12G > A variant

Article

作者: Carvalho, Livia S ; Lamey, Tina M ; Thompson, Jennifer A ; Chen, Fred K ; Fernando, Milan ; McLenachan, Samuel ; Gonzalez-Cordero, Anai ; Zhang, Dan ; McLaren, Terri L ; Zaw, Khine ; Chen, Shang-Chih

Autosomal recessive Usher syndrome (USH) is the most common inherited deaf-blindness disease, affecting one in 30,000 people worldwide.Here, we established two lines of induced pluripotent stem cells (iPSC) from a 48-year-old male carrier of a heterozygous NM_022124.6: c.1515-12G > A mutation in the CDH23 gene associated with USH type 1D. The reprogrammed iPSC lines had a normal karyotype, expressed pluripotency markers and showed the ability to differentiate into the three major developmental layers during embryoid body differentiation.

100 项与 Child & Adolescent Health Service 相关的药物交易

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100 项与 Child & Adolescent Health Service 相关的转化医学

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