A review.Double-stranded decoy oligodeoxynucleotides (ODNs) represent a new class of potential therapeutic drugs which can be designed to target specifically transcription factors involved in the pathogenesis of a given disease.There has been an explosion in the use of transcription factor decoys as tools for studying gene regulation and as exptl. therapy to treat a variety of pathol. conditions.Ongoing preclin. and clin. development programs at various emerging biotech companies, as well as academic research institutions, are currently elucidating the potential of this promising new class of biopharmaceuticals.
