Delving into the Latest Updates on 广西师范大学 with Synapse

概览

疾病领域	数量

肿瘤	8
免疫系统疾病	1

排名前五的药物类型	数量

小分子化药	3
化学药	2
诊断用放射药物	1
治疗用放射药物	1
合成多肽	1

排名前五的靶点	数量

NAMPT(烟酰胺磷酸核糖转移酶)	1
TNF-α(肿瘤坏死因子α)	1

关联

10

项与广西师范大学相关的药物

Zn-1

靶点-

作用机制-

在研机构

广西师范大学

原研机构

广西师范大学

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Gd-2Cu@AFt NPs

靶点-

作用机制-

在研机构

广西师范大学

原研机构

广西师范大学

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Compound 4d (Guangxi Normal University)

靶点-

作用机制-

在研机构

广西师范大学 [+1]

原研机构

广西师范大学

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

5

项与广西师范大学相关的临床试验

ChiCTR2400083689

/ Suspended临床1期IIT

A study of the effects of upper and lower extremity strength training on cognitive function under blood flow restriction

开始日期2024-05-01

申办/合作机构

广西师范大学

ChiCTR2400082292

/ Suspended临床1期IIT

Research on knee joint movement rehabilitation

开始日期2024-04-10

申办/合作机构

广西师范大学

ChiCTR2300079263

/ RecruitingN/AIIT

The Research on rehabilitation theory and method of newrehabilitation technology for sports injury

开始日期2024-01-01

申办/合作机构

广西师范大学

100 项与广西师范大学相关的临床结果

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0 项与广西师范大学相关的专利（医药）

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16,445

项与广西师范大学相关的文献（医药）

2025-12-31·International Journal of Image and Data Fusion

Road extraction model based on stripe expansion attention module and multi-stage features

作者: Yu, Yongyan ; Li, Zili

2025-12-31·Cogent Education

Augmented reality technology in a basic Chinese vocabulary course: a study in a Thai university

作者: Yanhua, Zhao ; Muangchan, Pattanasak

2025-10-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Vibrational spectroscopy investigation of ternary co-crystal formation of nitrofurantoin, nicotinamide and fumaric acid

Article

作者: Huang, Xianyi ; Pang, Wanting ; Qin, Binyi ; Li, Quanfu ; Wu, Huiping ; Zeng, Xiaoliu ; Chen, Xiaoqi ; Li, Tinghui ; Yang, Ruizhao

Pharmaceutical co-crystal technology, characterized by its green, simple, efficient, and potent nature, offers unique advantages in optimizing the pharmacological and physicochemical properties of drugs, thus providing an innovative strategy for the development of drug formulations. In this study, we successfully synthesized the nitrofurantoin-nicotinamide-fumaric acid co-crystal using dry grinding and comprehensively characterized it using vibrational spectroscopy techniques. PXRD spectral analysis indicates that the synthesized co-crystal is not merely a reproduction of the individual components or a product of physical mixing of the three, but represents the formation of a novel crystalline phase. This finding is further supported by results from terahertz (THz) spectroscopy and Raman vibrational spectroscopy. Infrared spectroscopy analysis suggests the formation of a co-crystalline structure among nitrofurantoin, nicotinamide, and fumaric acid molecules, mediated by hydrogen bonding interactions. In addition, this study used density functional theory (DFT) to optimize the co-crystal structure, thoroughly investigated key characteristics Hirshfeld surfaces and hydrogen bonds among other weak intermolecular interactions, and successfully determined the corresponding vibrational modes. These research outcomes not only substantiate the structural and intermolecular interactional intricacies within the nitrofurantoin-nicotinamide-fumaric acid co-crystal, but also provide a treasure of co-crystal structural insights for tailoring the physicochemical properties and pharmacological activities of specific drugs at the molecular level, with significant scientific value and application potential.

100 项与广西师范大学相关的药物交易

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100 项与广西师范大学相关的转化医学

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管线布局

2025年05月13日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

药物发现

2

7

临床前

其他

1

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当前项目

药物(靶点)	适应症	全球最高研发状态

Zn-2	肿瘤更多	临床前
PEP2(Tongji University) ( TNF-α )	炎症性肠病更多	临床前
Ga compound C4(广西师范大学)	肿瘤更多	临床前
Zn-1	肿瘤更多	临床前
Compound 4d (Guangxi Normal University)	肿瘤更多	临床前