Effectiveness of Momordica Charantia Extract Compared to the Standard Antimalarial Drug Combination Dihydroartemisinin Piperaquine-primaquine in Patients With Uncomplicated Falciparum Malaria, in Sumba Barat Daya District of Indonesia

Currently, the first-line combination of artemisinin, piperaquine and prima-quine is quite effective in controlling malaria, however, the threat of spread of drug-resistant parasites has been reported. A study is conducted to assess the efficacy and safety extract of bitter melon (Momordica charantia/MC) regimens compared to the combination of dihydroartemisinin piperaquine primaquine (DHP+PQ) on the sexual and asexual stage of P. Falciparum uncomplicated in Sumba Barat Daya District, Indonesia

开始日期2022-11-01

申办/合作机构

Pancasila University

NCT06036030

/ Completed临床2期IIT

Combination Momordica Charantia Extract and Primaquine Againts Plasmodium Falciparum Uncomplicated and Plasmodium Vivax Uncomplicated Treatment in Manokwari, West Papua

Comparing the efficacy of the combination treatment of bitter melon fruit extract (Momordica charantia) with primaquine (MC+PQ) against the combination of dihydroartemisinin + piperaquine + primaquine (DHP+PQ) on patients with Plasmodium falciparum and Plasmodium vivax without complications in Manokwari, West Papua, Indonesia. The research was conducted from January 2019 to April 2019 at Manokwari Regional General Hospital, West Papua. Open label, 2 parallel randomized clinical studies with Plasmodium falciparum malaria patients without complications (Study 1) and patients with Plasmodium vivax malaria without complications (Study 2). The randomized clinical trial divided in 2 treatment groups, namely the MC+PQ and DHP+PQ. The Success of the treatment was determined by the combination of blood schizontocidal therapy in radical cure. The overall final assessed results were the average value of parasitological failure, hematological measurements, liver function, kidney function, blood lipid levels, blood glucose levels and adverse events until day 42.

开始日期2019-01-11

申办/合作机构

Pancasila University

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项与 Pancasila University 相关的文献（医药）

2025-07-01·Applied Thermal Engineering

Employing sugar alcohol-based phase change material for integrated compact thermal battery (ICTB): experimental exploration for future configuration of modern space heating with thermal storage

作者: Rahman, Reza Abdu ; Nugroho, Agung ; Setiawan, Dibyo ; Dhewangga Putra, Robertus Dhimas

Coupling solar space heating (SSH) with thermal energy storage (TES) system is proven to supply clean energy for space heating in building sector.The TES typically employs low-d. (< 1 g/cm³) phase change material (PCM) to accommodate maximum temperature operation from the collector.This results in a low-d. TES unit, which is less feasible for modern building space heating.The study introduces integrated compact thermal battery (ICTB) using higher d. PCM (> 1.4 g/cm³) comes from sugar alc. group.Temperature limitation is solved by coupling the ICTB with elec. heater.The ICTB has an effective volume-to-weight ratio of 0.735 cm³/g, making the model extremely compact as TES tank.The maximum charge temperature is possible to reach 150 °C for sorbitol (SL) and xylitol (XL), while mannitol (ML) achieves higher limit (210 °C).The three PCMs have melting temperature above 90 °C with maximum latent heat of 275.36 J/g.The charge evaluation shows rating charge varies between 38.4-41.1 °C/kWh, which improves about 93.5% by introducing solid stripes.The solid stripe causes suitable temperature distribution inside the ICTB unit without requiring complex system modification.The discharge cycle able to increase the air temperature by 72.6%.This work shows the possibility of achieving higher d. TES system for modern space heating using ICTB configuration, providing valuable insight for the advanced development of the system, including the possibility of designing autonomous operations with a high potential for commercialization to support the energy transition in the building sector.

2025-04-26·International Journal of Construction Management

Impact of BIM and 3D printing technologies on production process and productivity of precast concrete in construction project

作者: Sari, Mustika ; Berawi, Mohammed Ali ; Miraj, Perdana ; Oktaviani, Astiti Dana ; Woodhead, Roy ; Susantono, Bambang

2025-03-01·Journal of Pharmacy & Pharmacognosy Research

Passiflora edulis Sims leaves ameliorate inflammation and prevent cartilage degradation in osteoarthritic rats by suppressing cytokines, nitric oxide, and matrix metalloproteinase-9

作者: Sari, Fania ; Desmiaty, Yesi ; Fahleni ; Muslimawati, Ravina ; Sandhiutami, Ni Made Dwi

Context: Treatment for osteoarthritis focuses on controlling pain, lowering inflammation, delaying cartilage deterioration, and minimizing impairment. Aims: To evaluate the bioactivity of leaf extract 'markisa' (Passiflora edulis, MLE) as an in vitro radical scavenger, and an in vivo edema reducer and pro-inflammatory mediators in an osteoarthritis rat model. Methods: MLE was prepared by an ultrasonication method with ethanol. First, the in vitro antioxidant activity of MLE was assessed with ABTS reagent, and the total phenolics (TPC) and flavonoid (TFC) contents were determined. Furthermore, in vivo tests were conducted. Wistar rats were induced osteoarthritis by intraarticular injections of sodium iodoacetate (13.5 mg/kg BW) and observed for one month. MLE was administered orally to animal models in doses of 100, 200, and 400 mg/kg BW every day for two weeks. Body weight and knee edema enlargement were observed every week. At week 6th, all animals were sacrificed for evaluation of spleen weight, hematology analysis (leukocyte and lymphocyte number), and pro-inflammatory mediators assay (NO, IL-6, TNF-α, and MMP-9). Results: This study showed that MLE has antioxidant capacity 13.26 ± 0.7 mol TE/g, TPC 8.17 ± 0.03 mg GAE/g, and TFC 3.28 ± 0.3 mg QE/g. In vivo tests showed that MLE-treated rats had reduced knee edema, hematological improvement (decreased NO, IL-6, and TNF-α), spleen enlargement, and protection against cartilage degradation by decreasing MMP-9. Conclusions: These findings suggest that MLE therapy has the potential to restore the state of osteoarthritic rats to normal, with varying degrees of dose-dependent improvement.

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