Efficacy of ultrasound guided fascia transversalis plane block and lateral quadratus lumborum block during inguinal hernia repair - A randomised comparative single blinded study - NIL

开始日期2025-04-26

申办/合作机构

Mahatma Gandhi Medical College & Research Institute

CTRI/2025/04/084666

/ Not yet recruiting临床4期

Comparison of the effectiveness of fractional carbon di oxide laser and retinoic acid peel in the treatment of acanthosis nigricans: a randomized, controlled trial - NIL

开始日期2025-04-14

申办/合作机构

Mahatma Gandhi Medical College & Research Institute

CTRI/2024/10/075851

/ Not yet recruitingN/A

To analyze the utility of deltaPCO2 gap / AVO2 content difference ratio in the assessment of tissue hypoperfusion secondary to low cardiac output state during obtuse marginal artery distal anastomosis in off-pump coronary artery bypass grafting. - NIL

开始日期2024-11-21

申办/合作机构

Mahatma Gandhi Medical College & Research Institute

100 项与 Mahatma Gandhi Medical College & Research Institute 相关的临床结果

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0 项与 Mahatma Gandhi Medical College & Research Institute 相关的专利（医药）

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295

项与 Mahatma Gandhi Medical College & Research Institute 相关的文献（医药）

2025-12-01·Molecular Biology Reports

Exploring the regulatory role of small RNAs in modulating host-pathogen interactions: implications for bacterial and viral infections

Review

作者: Ranganadin, Pajanivel ; Green, Siva Ranganathan ; Srinivasan, Rajesh ; Ramadoss, Ramya ; Kandasamy, Vanathy ; Pillai, Agieshkumar Balakrishna ; Kasirajan, Anand

MicroRNAs (miRNAs) and transfer RNA-derived stress-induced RNAs (tiRNAs) have emerged as crucial players in the post-transcriptional regulation of gene expression in various cellular processes, including immunity and host defense against infections. In recent years, increasing evidence has highlighted their complex role in influencing the host response during viral and bacterial infections. miRNAs have been shown to play multiple roles in host-pathogen interaction like TLR activation and altered disease virulence during bacterial infections. In the context of viral infections, miRNAs are involved in regulating viral replication, pathogenesis, and immune evasion. Similarly, tiRNAs have recently emerged as novel players in bacterial and viral infections such as modulating bacterial growth, adaptation to stress conditions, host antiviral responses, and impacting viral replication and pathogenesis. This review provides a comprehensive analysis of the potential of miRNA expression profiles as diagnostic biomarkers to differentiate between bacterial and viral infections. Further discusses the key pathways through which small RNAs regulate bacterial and viral infection-related diseases.

2025-08-01·Current Pediatric Reviews

Cord Blood Cortisol Level - A Possible Predictor for Respiratory Distress Syndrome in Preterm Neonates

Article

作者: Thomas, Anup John ; Gunasekaran, Dhandapany ; Palanisamy, Soundararajan ; Chhavi, Nanda ; Venkatesh, Chandrasekaran

Background::Respiratory Distress Syndrome (RDS) is a leading cause of death in premature infants. There are different clinical/ biochemical markers associated with the RDS. One of the potential biochemical markers is cortisol in cord blood.Purpose::This study aims to correlate cortisol levels in preterm neonates with RDS and to establish whether cord blood cortisol is a reliable predictor for RDS.Materials and Methods::This prospective analytical study was conducted in a tertiary care hospital over nine months among fifty preterm neonates. Data was collected using proforma, and cord blood was collected at the time of delivery. Cortisol levels were compared and correlated to the development of RDS.Results and Discussion:The mean ± SD cord blood cortisol level among preterm neonates was 5.97 ± 2.74 (SD) μg/dl. The levels were higher in neonates whose mothers received antenatal steroids and were significantly lower (2.86 ± 1.66 μg/dl) in those who developed RDS. Association between cord blood cortisol level and RDS was found with an odds ratio of 57.4, which was statistically significant. The percentage of babies developing RDS in mothers not covered with antenatal steroids was significantly higher than those covered (p-value is 0.000). The mean cord blood cortisol levels were exceptionally low (1.89 μg/dl) in neonates who expired compared to those who survived (7.02 μg/dl).Conclusion::There is an association between cord blood cortisol levels and RDS. Hence, Cord blood cortisol levels may be used to predict RDS and help initiate early treatment, thus preventing mortality and morbidity.

2025-05-01·Microchemical Journal

Novel Dy doped BiOCl nanomaterials for electrochemical sensing of dopamine and fingerprint applications

作者: Sharma, S. C. ; R, Reeta ; Das, B. K. ; Nadar, Nandini Robin

Recent studies in dopamine detection prioritize enhancing techniques for superior sensitivity and selectivity, incorporating methods such as electrochem., spectroscopy, and nanomaterial-based sensors.Given dopamine's (DA) essential role in neurol. processes, precise detection is vital for diagnosing and managing conditions such as Parkinson's disease, schizophrenia, and addiction.This study reports the synthesis of Dysprosium-doped bismuth oxychloride (BOCD) nanocomposites, which demonstrated outstanding sensitivity in dopamine detection.Cyclic voltammetry anal. revealed that 7 mol% Dy-doped BiOCl nanocomposites exhibited significant performance, with a detection limit of 0.683μM and a limit of quantification (LOQ) of 2.27μM at neutral pH (7).The modified electrode displayed excellent selectivity for DA even in the presence of uric acid (UA) and maintained strong stability, retaining 92.12% of its performance after 20 cycles.Addnl., BOCD nanoparticles enhanced fingerprint visualization, producing distinct ridge patterns and high-resolution minutiae on surfaces such as aluminum foil leaf and glass.The enhanced contrast enabled the identification of key minutiae, including right loops, bifurcations, and dots, essential for detailed forensic anal.The material also delivered strong pixel intensity contrasts and detailed 3D ridge profiling, supporting accurate forensic and biometric identification.

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