Phase 2 Single Center, Randomized, Placebo-controlled, Double-blind, Parallel Group Study to Evaluate Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients with Sepsis

Meta-and ortho-Tyrosine are known markers of oxidative stress, while the physiological isomer, para-Tyrosine is suggested the antagonize the effects of meta- and ortho-Tyrosine. The changes in the serum levels of meta- and ortho-Tyrosine have been found to be paralel to that of the common sepsis markers. The hypothesis of the study is, that supplementation of para-Tyrosine (p-Tyr) in the early phase of sepsis may diminish some specific inflammatory procedures and thus may have a favourable impact on the disease progress, and consequently on the mortality.

开始日期2027-01-01

申办/合作机构

University of Pecs

NCT05060731

/ Not yet recruiting临床4期IIT

Intravenous Ferric Carboxymaltose Versus Oral Ferrous Sulfate Replacement in Anaemia Due to Acute Nonvariceal Gastrointestinal Bleeding (FIERCE): Protocol of a Multicentre Randomised Controlled Trial

Anemia is a frequent complication of gastrointestinal bleeding, affecting 61% of the patients. Currently, anemia caused by gastrointestinal bleeding can be treated with iron supplementation. However, the dose and route of the administration are still a question. The FIERCE clinical trial aims to compare the effect of intravenous iron supplementation and oral iron replacement on mortality, unplanned emergency visits, and hospital readmissions in multimorbid patients with acute nonvariceal gastrointestinal bleeding.

开始日期2025-09-01

申办/合作机构

University of Pecs

NCT06795568

/ Not yet recruitingN/AIIT

Examination of Fertility Awareness with an Integrative Approach: a Mixed-method Multi-centre Research Study

The goal of this observational study is to investigate integrative fertility awareness and its impact on assisted reproductive techniques (ART) in Hungary. It analyzes fertility awareness, health-movement behavior, physical literacy, dietary patterns, psycho-social distress, socio-demographic parameters, and stress biomarkers across four fertility centers. The study employs a mixed-method approach. The research aims to review and analyze the factors of integrative fertility awareness on the course and outcome measures of assisted reproductive techniques (ART) at different fertility centers in Hungary in a mixed-method study.

开始日期2025-02-15

申办/合作机构

University of Pecs

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2025-12-31·Cogent Education

Trends in research on reciprocal teaching: a systematic review

作者: Vuong, Tuyet Linh ; Steklács, János

2025-12-31·Journal of Psychosomatic Obstetrics & Gynecology

Risk perception, health behavior and mental health of women living with polycystic ovary syndrome

Article

作者: Teleki, Szidalisz Ágnes ; Rafael, Beatrix ; Bali, Cintia ; Töreki, Annamária ; Tóth, Erika

This study aimed to explore the psychological challenges faced by women living with polycystic ovary syndrome (PCOS) and their subjective experiences. Using a cross-sectional, questionnaire-based design, we first conducted a comparative analysis of responses from 54 PCOS patients and 54 age-matched healthy participants. The analysis revealed a significant difference in satisfaction with life (SWL) between the two groups (F = 9.426, p < .005), while no significant differences were found in levels of anxiety and depression. Additionally, depression was found to have a significant impact on SWL (F = 55.309, p < .001). To further investigate the subjective well-being of PCOS patients, a larger group of 389 PCOS patients (age: M = 32.18 years, SD = 8.34) completed the Polycystic Ovary Syndrome Questionnaire (PCOSQ) (QoL Scale). A ranking of their concerns revealed that obesity-related issues were the most significant, while concerns about developing cancer were ranked last. The PCOSQ scores showed a strong negative correlation with the BDI (r = -0.754, p < .001), highlighting the profound impact of PCOS symptoms on depression. These findings underscore the importance of prevention, screening and treatment for depression in PCOS patients, as well as the importance of educating patients to improve their risk perception and disease management strategies.

2025-12-01·Techniques in Coloproctology

To cut or not to cut? Extended mesenteric excision during intestinal resection does not impact the postoperative recurrence nor the postoperative complications in Crohn’s disease: a systematic review and meta-analysis

Review

作者: Topala, M ; Lenti, K ; Martinekova, P ; Erőss, B ; Hegyi, P ; Rancz, A ; Miheller, P ; Ábrahám, S ; Veres, D S

AbstractBackgroundThe mesentery might be involved in the pathogenesis of Crohn’s disease (CD). As a result of scarce and conflicting data, it is debatable whether removal during intestinal resections could influence postsurgical outcome. We aimed to investigate the association between the extent of mesenteric excision during intestinal resections and postoperative complications and recurrence.MethodsWe conducted a systematic search in five databases on 29 July 2024 for studies reporting outcomes in patients with CD who underwent intestinal resections with extended mesenteric excision (EME) compared with limited mesenteric excision (LME). Pooled odds ratios (ORs) with 95% confidence intervals (CI) were calculated using the random-effects model. We assessed the risk of bias using the ROBINS-I and RoB2 tool and evaluated the certainty of evidence according to the GRADE Working Group recommendations.ResultsWe retrieved data from six studies, covering 4590 patients. The pooled data showed no significant difference between EME and LME patients regarding surgical recurrence (OR 0.3; 95% CI 0.02–3.73; p = 0.176), overall postoperative complications (OR 0.78; 95% CI 0.33–1.82, p = 0.329), anastomotic leak (OR 0.76, 95% CI 0.09–6.85, p = 0.722), surgical site infection (OR 0.84, 95% CI 0.3–2.36, p = 0.539), reoperation rate (OR 1.09, 95% CI 0.33–3.58, p = 0.783), or hospitalization (MD − 0.33 (95% CI − 1.8 to 1.15, p = 0.53). Individual studies reported similar results regarding 6 months follow-up endoscopic recurrence. The certainty of evidence was very low and low, respectively.ConclusionExtended mesenteric excision is not statistically associated with improved postoperative complications or postoperative recurrence. Results should be interpreted cautiously because of the small number of studies; hence, randomized, long-term, controlled trials are needed.

项与 University of Pecs 相关的新闻（医药）

2024-08-02

·drugs

Semaglutide Products Being Sold Online Without Prescriptions

FRIDAY, Aug. 2, 2024 -- Semaglutide products are being sold online, with products likely unregistered or unlicensed, according to a research letter published online Aug. 2 in JAMA Network Open . Amir Reza Ashraf, Pharm.D., from the University of Pécs in Hungary, and colleagues conducted a risk assessment of semaglutide online sourcing. Websites advertising semaglutide without a prescription were cataloged in July 2023; those meeting inclusion criteria were selected for a product test buy protocol. Two 0.25-mg dose prefilled pens or equivalent injection vials were ordered from each website and compared to genuine Ozempic brand 1-mg semaglutide solution. Six online vendors classified as not recommended or rogue and offering parenteral semaglutide products were included in the test buys. Three offered prefilled 0.25-mg/dose semaglutide injection pens and three sold vials of lyophilized semaglutide. The researchers found that genuine Ozempic scored the full 22 points on the International Pharmaceutical Federation (FIP) checklist, while test purchased products scored 8 or 9; clear discrepancies were seen in regulatory registration information, accurate labeling, and evidence that products were likely unregistered or unlicensed. One sample had elevated endotoxin, indicating possible contamination. The presence of semaglutide was revealed in all samples, with considerably low purity levels (7 to 14 percent versus 99 percent advertised). In each sample, the measured semaglutide content substantially exceeded the labeled amount. "Semaglutide products are actively being sold without prescription by illegal online pharmacies, with vendors shipping unregistered and falsified products," the authors write. "Two websites evaluated were sent FDA warning letters for unlawful sale of unapproved and misbranded semaglutide." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

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