The study aims to obtain a panel of biomarkers from hypoglycemic diabetic patients with either type 1 or type 2 diabetics and from control patients with type 1 or type 2 diabetes who didn't have hypoglycemia in the last 72 hours.

开始日期2024-03-03

申办/合作机构

Royal College of Surgeons in Ireland - Medical University of Bahrain

[+1]

NCT05781243

/ Completed临床4期IIT

Normal Saline Versus Lactated Ringer's Solution for Acute Pancreatitis Resuscitation, an Open-label Multicenter Randomized Controlled Trial: the WATERLAND Trial

Background: Some evidence suggests that fluid resuscitation with lactated Ringer's solution (LR) may have an anti-inflammatory effect on acute pancreatitis (AP) when compared to normal saline (NS), and may be associated with a decrease in severity, but existing single center randomized controlled trials showed conflicting results. The WATERLAND trial aims to investigate the efficacy and safety of fluid resuscitation using LR compared to NS in patients with AP.
Methods: The WATERLAND trial is an international multicenter, open-label, parallel-group, randomized, controlled, superiority trial. Patients will be randomly assigned in a 1:1 ratio to receive LR versus NS-based fluid resuscitation for at least 48 hours. The primary outcome will be moderately severe or severe AP, according to the revision of the Atlanta classification. The secondary objectives of the WATERLAND trial are to determine the effect of LR versus NS fluid resuscitation on several efficacy and safety outcomes in patients with AP.
A total sample of 720 patients, 360 in the LR group and 360 in the NS group, will achieve 90% power to detect a difference between the group proportions of 10%, assuming that the frequency of moderately severe or severe AP in the LR group will be 17%. A loss to follow-up of 10% of patients is expected, so the total sample size will be 396 patients in each treatment arm (792 patients overall). The test statistic used is the two-sided Z test with pooled variance set at a 0.05 significance level.
Discussion: The WATERLAND study aims to improve the early management of AP. Fluid resuscitation is an inexpensive treatment available in any hospital center worldwide. If a better evolution of pancreatitis is demonstrated in one of the treatment arms, it would have important repercussions in the management of this frequent disease.

开始日期2023-06-19

申办/合作机构

King Hamad General Hospital

[+18]

ISRCTN17536874

/ CompletedN/AIIT

A study to evaluate the correlation between anatomical landmark ultrasound imaging estimation of intervertebral level

开始日期2023-04-01

申办/合作机构

King Hamad General Hospital

100 项与 King Hamad General Hospital 相关的临床结果

登录后查看更多信息

0 项与 King Hamad General Hospital 相关的专利（医药）

登录后查看更多信息

381

项与 King Hamad General Hospital 相关的文献（医药）

2025-06-01·Radiology Case Reports

Incidentally discovered monostotic Paget's disease involving the scapula inducing brachial plexopathy: A diagnostic dilemma

Article

作者: Aladel, Fouad ; Alsaleh, Bano ; Alanzi, Ahmed

Paget disease of bone is a chronic skeletal disorder characterized by abnormal bone remodeling. This condition, which predominantly affects older adults, can result in a variety of complications, including bone pain, fractures, and deformities. This case report discusses the incidental discovery of monostotic Paget's disease involving the scapula, leading to brachial plexopathy in a 58-year-old female with a history of colon cancer. The patient had severe bilateral shoulder pain, predominantly on the left, for the past ten years. This pain, exacerbated by overhead activity and limiting daily functions, radiated to the upper limbs without causing weakness or sensory deficits. Clinical examination revealed 4/5 limb power and normal sensation, with significant pain on left shoulder movement and limited elevation. Radiographic investigations, including bilateral shoulder radiographs, contrast-enhanced computed tomography (CT), and cervical magnetic resonance imaging (MRI), identified no displaced fractures but showed diffuse enlargement of left shoulder muscles with fatty infiltration, medullary expansion of the scapula, and reduced left lung volume. MDP skeletal scintigraphy with SPECT/CT confirmed asymmetrical radiotracer uptake and medullary expansion in the left scapula. Further, MRI of both shoulders revealed left-sided expansion, cortical thickening, and fatty replacement of the rotator cuff and deltoid musculature due to denervation pseudohypertrophy from left brachial plexopathy. The right shoulder MRI showed rotator cuff tendinopathy and tears. The findings suggest a diagnosis of monostotic Paget's disease with secondary brachial plexopathy.

2025-06-01·Hong Kong Physiotherapy Journal

Ataxia telangiectasia in a Bahraini child treated with intensive physiotherapy: A case report

作者: Albastaki, Aysha ; Sinan, Israa ; Razzaqi, Fatima

Ataxia telangiectasia (AT) is a rare neurodegenerative condition with a prevalence of 1 in 40,000 to 1 in 300,000 worldwide. It involves a genetic mutation of chromosome 11q.26. The condition is inherited in an autosomal recessive manner causing atrophy of the cerebellum due to loss of Purkinje fibres. AT presents early in childhood and the clinical features depend on the type of mutation. The study is a case report of a rare genetic disorder of a 9-year-old female who came to the physiotherapy clinic with a diagnosis of AT. The patient was presented with progressively worsening gait problems with frequent falls, with complete dependence on assistance and impaired balance and coordination. The treatment program was 12 months divided into an intense physiotherapy program for two months followed by 10 months of two times per week of physiotherapy sessions. The program was divided into four elements which are: (1) Lifestyle changes, (2) Strengthening exercises, (3) Coordination exercises, and (4) Balance training exercises. The result showed a positive outcome in increasing the patient’s independence, increased muscle strength, reduced ataxia symptoms intensity, and the patient can carry out complex activities with the help of accessory orthosis devices.

2025-03-03·JNCI Cancer Spectrum

Prostate cancer screening in the Middle East and North Africa: a cross-sectional study on current practices

Article

作者: Alali, Bader ; Leeman, Jonathan E ; Mejri, Nesrine ; Hammoudeh, Lubna ; Nguyen, Paul L ; Ibrahim, Ahmed H ; Bounedjar, Adda ; Obeidat, Salameh ; Barki, Ali ; Aynaci, Ozlem ; Mohammadipour, Sepideh ; Pervez, Nadeem ; Abu Abeelh, Enas ; Kadri, Mohamad ; Alhaddad, Zeinab ; Moningi, Shalini ; Al Hussain, Hussain ; Mula-Hussain, Layth ; Badheeb, Ahmed M ; Junaid, Moamin ; D’Amico, Anthony V ; Tuac, Yetkin ; Jdaini, Ahmed ; Elfagieh, Mohamed A ; Orio, Peter F ; Sayan, Mutlay ; Abu Ghida, Ibrahim

AbstractBackgroundProstate cancer is a substantial health concern in the Middle East and North Africa region, with many cases diagnosed at advanced stages, a high mortality to incidence ratio, and low prostate cancer awareness. This study aimed to evaluate prostate cancer screening practices in the region to inform effective early detection and management strategies.MethodsA cross-sectional survey was conducted from July 1, 2023, to November 8, 2024, among physicians from 19 countries in the Middle East and North Africa region. The study used a validated questionnaire to assess prostate cancer screening practices, barriers, and educational needs.ResultsThe survey had a response rate of 96.8% and 1163 participants. Of these participants, 34.7% routinely performed prostate cancer screenings, with 61.1% using prostate-specific antigen tests. The primary barrier was lack of patient awareness (51.2%). In addition, 65.3% of participants had no formal training. To improve screening rates, participants suggested better patient education (63.5%), increased training for health-care professionals (41.9%), and improved access to screening equipment (38.9%).ConclusionThis study revealed that prostate cancer screening rates were low, with barriers including a lack of patient awareness and formal training among physicians. Addressing these issues through culturally tailored education programs may improve early detection rates and ultimately reduce the burden of prostate cancer in the Middle East and North Africa region.

100 项与 King Hamad General Hospital 相关的药物交易

登录后查看更多信息

100 项与 King Hamad General Hospital 相关的转化医学

登录后查看更多信息