Micronuclear Frequency in Buccal Smear and its Correlation with Histopathological Dysplasia, p53 and p16 Expression in Oral Potentially Malignant Disorders and Squamous Cell Carcinoma - NIL

开始日期2024-11-07

申办/合作机构

Nil Ratan Sircar Medical College

CTRI/2024/07/070562

/ Not yet recruiting临床3期IIT

Efficacy of USG guided genicular nerve block with aqueous phenol(6%),ethyl alcohol(95%) and triamcinolone(20mg)with lignocaine(2%)-a randomized controlled trial. - NIL

开始日期2024-08-22

申办/合作机构

Nil Ratan Sircar Medical College

CTRI/2022/02/040047

/ Not yet recruiting临床4期IIT

Comparison Between Bupivacaine-Dexmedetomidine Versus Bupivacaine Alone In Erector Spinae Plane Block For Postoperative Analgesia After Modified Radical Mastectomy. A Prospective Comparative Study.

开始日期2022-02-15

申办/合作机构

Nil Ratan Sircar Medical College

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134

项与 Nil Ratan Sircar Medical College 相关的文献（医药）

2025-04-01·Amrita Journal of Medicine

Plexiform Schwannoma Over the Anterior Chest Wall: A Clinicopathological Review

作者: Sasmal, Debojyoti ; Barenya, Saswata ; Saha, Hinglaj ; Halder, Pankaj Kumar

AbstractPlexiform schwannoma (PS) is a rare type of schwannoma, accounting for only 5% of all schwannomas, with most cases occurring in the skin and subcutaneous tissue and showing a predilection for the head and neck region, similar to ordinary schwannomas. The diagnosis is confirmed by the histopathological examination. The therapy of choice is surgical excision with biopsy. Tumor recurrence is limited locally without any metastatic potential. Here, we present a case of a 1-year-and-7-month-old male child with a firm lesion in the left anterior chest, which was excised completely, and the biopsy came up as PS.

2025-04-01·Diabetology International

Pathophysiological hallmarks in type 2 diabetes heterogeneity (review)

Review

作者: Datta, Dipamoy ; Basu, Rajdeep ; Chakrabarti, Partha ; Kundu, Raja

The mechanistic complexity in type 2 diabetes (T2DM) is primarily responsible for the degrees of heterogeneity and development of complications. A complex mode of interactions between different pathophysiological events and diabetogenic environmental factors support for the genesis of diabetes heterogeneity both in phenotypic and clinical contexts. The currently used diabetes classification strategies suffer from several inconsistencies that cannot fully capture the inherent heterogeneity among the diabetes patients. To effectively address this pathobiological and heterogeneity-related issue in diabetes research, the current review proposes nine pathophysiological hallmarks of T2DM that aims to mechanistically explain complexities of diabetes associated pathophysiological events and their underlying features. These pathophysiological hallmarks are pancreatic beta cell dysfunction, insulin sensitivity, insulin resistance, obesity, aging, subclinical inflammation, metabolic dysregulation, prothrombotic state induction and hypertension. Detail knowledge of these pathophysiological hallmarks with their key molecular mediators, influencing factors, clinical biomarkers and clinical assessment methodologies will greatly support precision medicine approaches in diabetes including patient stratification, subtype diagnosis and treatment.Supplementary InformationThe online version contains supplementary material available at 10.1007/s13340-024-00783-w.

2025-03-11·Circulation

Abstract P1066: Improved Access to Cardiovascular Care Reduces Ischemic Heart Disease Mortality in Rural Ohio

作者: Gupta, Anjan ; Bhowmik, Suryasnata

Introduction: Ischemic heart disease (IHD) remains a leading cause of death globally, with its impact disproportionately higher in underserved regions, where access to specialist care is limited. In rural areas like Portage County, Ohio, geographic isolation and lack of local healthcare options have led to delayed treatment and poor outcomes. In 2016, a local catheterization (cath) lab, alongside comprehensive cardiovascular screening and prevention programs, was established to address the issue. Hypothesis: We assessed the hypothesis that the introduction of local specialist cardiovascular services would be associated with a reduction in crude death rates (CDRs) from IHD in Portage. Methods: This retrospective study analyzed CDRs for IHD (reported per 100,000) from the CDC WONDER database (Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research) from 2000 to 2019, stratified by age group. Hospital records provided data on angiograms performed from 2016 to 2022. We utilized linear regression and interrupted time series analysis to evaluate correlation between the intervention and CDR trends. As the study used publicly available secondary data and anonymized hospital records, no ethics approval was required. Results: From 2016 to 2019, over 3000 catheterizations were performed. During this period, a general decline in CDRs was observed across all age groups, especially in the older groups: in the 65-74 age group, rates dropped by 36% (294.2 in 2015 to 188.1 in 2019), while the 75-84 and 85+ age groups saw declines of 21% (817.1 to 648.6) and 28% (3715.6 to 2657.8), respectively. However, statistical significance (p>0.05) was not reached due to limited post-intervention dataset. Conclusion: Early findings suggest that increasing access to specialist cardiovascular services may be associated with reduced IHD mortality in underserved regions like Portage. However, other factors like healthcare improvements, may have also influenced the results, and further analysis with a longer post-intervention period and comparison with control regions are needed to confirm these trends. These early results nonetheless offer insights into the potential of such specialist services to improve health outcomes in rural and underserved regions.

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