OBJECTIVE To study the effect of the particle size of the raw material drug on the dissolution of albendazole tablets, and to investigate the consistency of the in Vitro dissolution profiles of the self-made tablets and the reference tablets. METHODS Different methods were used to process the raw materials, and the similarity factor f2 value of the dissolution curves of the self-made tablets and the reference tablets were compared. RESULTS The particle size d (0.5) of the raw material drug were controlled at 5-10 μm and d (0.9) at 10-20 μm, which could make the in Vitro dissolution of the self-made tablets and the reference tablets similar. CONCLUSION The appropriate particle size control range of the raw material drug is determine, and the product stability is good.