The goal of this clinical trial is to learn if whether vibration therapy relieves the intensity of Restless legs syndrome (RLS) symptoms and sleep disturbances among patients undergoing hemodialysis. The main question it aims to answer is:
Is there a difference in the levels of legs restless syndrome and sleep disturbances between hemodialysis patients who receive vibration therapy and those who do not receive it?
Researcher will compare the levels of legs restless syndrome and sleep disturbances between hemodialysis patients who receive vibration therapy and those who do not receive it to see if vibration therapy works to relieve the levels of legs restless syndrome and sleep disturbances.
Participants will take vibration therapy applied on the calf muscle for 10 minutes per session, 2 times per week for total one month, during the first hour of each hemodialysis sessions.

开始日期2025-04-01

申办/合作机构

University of Kufa

NCT06210139

/ CompletedN/A

Evaluating the Prescribing Pattern and Knowledge, Attitude and Practice as Well as the Adherence Level to Iron Chelation Therapy in Thalassemia

Thalassemias are a heterogeneous grouping of genetic disorders that result in dysfunctional Hb, reduced RBC life span leading to chronic anemia . Thalassemia is endemic in the Middle East. Iron chelation therapy (ICT) is one of treatment used however ICT is associated with patients adherence problem thus impacting its effectiveness .

开始日期2023-03-28

申办/合作机构

University of Kufa

NCT05540431

/ Unknown status临床2/3期

Evaluation of Protective Effect of Activated Charcoal and Probiotic Against Progression of Chronic Kidney Disease

Investigate the nephroprotective effect of Activated Charcoal and Probiotic in limiting the progression of renal impairment in patients with chronic kidney disease and improving of renal function test and phosphate level.
Condition or disease:
chronic kidney disease

开始日期2022-09-25

申办/合作机构

University of Kufa

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项与 University of Kufa 相关的文献（医药）

2025-12-01·Molecular Biology Reports

Association of XRCC1 (rs1799782) and XPD (rs13181) gene polymorphisms with renal failure risk in a sample of Iraqi population: a case–control study

Article

作者: Al-Koofee, Dhafer A F ; Abo-Ghneim, Fahad D F ; Mohammed, Hussain Jasem

BACKGROUNDEnd-stage chronic kidney disease (CKD) can lead to life-threatening complications and is caused primarily by CKD and cardiovascular issues. CKD is characterized by the inability of the kidneys to filter waste and excess fluids from the blood. This study investigated the associations of the genetic variants XRCC1 rs1799782 (C194T) and ERCC2/XPD rs25487 (Q399R) with CKD susceptibility in Iraqi patients and related biochemical changes.METHODSThe research was performed from 25/01/2023 to 30/06/2023, we analyzed the genetic associations of two SNPs of DNA repair genes (XRCC1 and ERCC2/XPD) in a case‒control study involving 219 CKD patients diagnosed by a nephrologist and 246 healthy controls. Data and blood samples were collected, and the genotype distribution frequency was determined via the PCR-based high-resolution melting (PCR-HRM) technique.RESULTSThis study included 465 participants, with 219 CKD patients and 246 healthy controls. XRCC1 and ERCC2/XPD gene polymorphisms were significantly associated with CKD susceptibility in Iraqi patients (p = 0.025 and p = 0.0001, respectively). Multivariate linear regression confirmed the associations of rs1799782 G/A and rs13181T/G with CKD, adjusting for sex, age, and BMI. Moderate and statistically significant linkage disequilibrium (0.43) between the two SNPs was observed, indicating nonrandom associations.CONCLUSIONXRCC1 (rs1799782) and ERCC2/XPD (rs13181) polymorphisms are associated with an increased risk of CKD. The AG haplotype model is particularly related to increased CKD susceptibility in Iraqi patients, suggesting the importance of these DNA repair gene polymorphisms in CKD risk assessment.

2025-06-01·Applied Radiation and Isotopes

The relationship of Cadmium, Lead, and Uranium with the geographical location of non-smoking Thalassemia individuals: A comparative study

Article

作者: Kadhim, Shaymaa Awad ; Abdulrudha, Noor Hassan

BACKGROUND AND AIMSThalassemia is a group of heterogeneous hemolytics. Anemia is characterized by autosomal recessive inheritance Due to impaired synthesis of hemoglobin (Hb). The most common types of Thalassemia are Thalassemia and beta-thalassemia, which are named for the hemoglobin chains they affect. Blood from Thalassemia patients differs from the blood of healthy human beings due to function abnormalities such as reduced hemoglobin synthesis, changed crimson blood cell architecture, and scientific indicators of anemia. Heavy metal (HM) toxicity has been described as a risk factor for the development of Thalassemia in women and men; its assessment can predict susceptibility to Thalassemia (Thal.) HM levels of Cadmium (Cd), Lead (Pb), and Uranium (U) were evaluated in non-smoking individuals from outside and inside the holy city of Najaf. Eighty-two females, aged (9-40) years, and forty controls (11-45) years, were recruited into this case-control study. As well as the possibility of a relationship between the disease and radiation through detection of blood Uranium levels.METHODThe concentration values of the studied elements were determined in units (ppb) for Cadmium and lead after their digestion using flame atomic absorption spectrometry (FAAS). In contrast, uranium concentrations (ppb) were measured using a solid-state nuclear track detector (CR 39) by measuring the radon concentration.RESULTSThe average ± standard deviation (SD) for (Cd) concentrations in the serum of the control group were higher (19.405 ± 1.117) ppb compared to the serum of Thalassemia individuals (1.570 ± 0.658)ppb, with high statistical significance (P < 0.05), while (Pb) in the serum of the control group (32.051 ± 8.423) ppb and vice versa was the lowest compared to the serum of Thalassemia individuals, with high statistical significance. As for (U) concentrations, they were close between the two groups, respectively, and the p-value was greater than 0.05. The ANOVA analysis between the concentrations of the studied elements was statistically significant. Cd was positively correlated with Pb (r = 0.204, P = 0.066). The relationship between Cd and U has been neglected (r = 9.011, P = 0.922). As for Pb and Cd, the correlation was positive and weak (r = 0.204, P = 0.066).CONCLUSIONThe serum concentrations of the studied elements in Thalassemia individuals outside the city of Najaf were higher than those of Thalassemia individuals inside the city of Najaf. The current study showed a difference in the mean differences in the concentrations of the studied elements between the Thalassemia group and the control group, and the location was important, as it was found that the concentrations were higher for the Thalassemia group outside the city of Najaf compared to the Thalassemia group inside the city.

2025-05-01·Journal of Alloys and Compounds

Synergistic defect passivation and charge transport enhancement via thiosemicarbazide-functionalized carbon nanotubes for high-efficiency lead-free CsSnI₃ perovskite solar cells: A pathway to 23.34 % efficiency

作者: Mahmoud, HassabAlla M. A. ; Zorah, Mohammed ; Mohammed, Mohammed Ahmed ; Nassar, Maadh Fawzi ; Ahmed, Abbas M. E. ; Alshaeer, Fadwa ; Mohammed, Bassam A. ; Abdulkareem-Alsultan, G. ; Alharbi, Nouf

Tin-based perovskite solar cells (PSCs) provide a lead-free alternative but suffer from Sn(II) instability.We introduce thiosemicarbazide-functionalized carbon nanotubes (TSBCNTs) to minimize defects and improve charge transport in all-inorganic CsSnI₃(PSCs.The S=C=N groups of TSBCNT interact with Sn²⁺, diminishing trap states, while CNTs enhance carrier extraction, resulting in a PCE of 23.34 % and a stability of 91.3 % after 800 h under severe circumstances.

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