近日,一篇发表在国际杂志Nature Cancer上题为“Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer”的研究报告中,来自Wistar研究所等机构的科学家们通过研究揭示了机体抵御一种侵袭性强且难以治疗的乳腺癌的双重作用机制,同时他们还阐明了沉默ACSS2基因是如何改善当前患者的治疗的。
Miller, K.D., O’Connor, S., Pniewski, K.A. et al. Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer. Nat Cancer (2023). doi:10.1038/s43018-023-00636-6