近日,来自山东大学的研究者们在Cellular and Molecular Life Sciences杂志上发表了题为“BMI1 promotes cholangiocarcinoma progression and correlates with antitumor immunity in an exosome‑dependent manner”的文章,该研究描述了BMI1在外体介导的CCA肿瘤发生和转移中的一个新功能。此外,BMI1抑制可能通过激活CCA的细胞内源性免疫而增强免疫检查点的阻断,从而抑制肿瘤的进展。
Zengli Liu et al. BMI1 promotes cholangiocarcinoma progression and correlates with antitumor immunity in an exosome‑dependent manner. Cell Mol Life Sci. 2022 Aug 6;79(9):469. doi: 10.1007/s00018-022-04500-1.