EpCAM, a broadly expressed, validated cancer target rescued by novel antibody technologies
2023-10-24
BARCELONA, Spain I October 24, 2023 I La Merie Publishing released its newest product reviewing the pipeline of anti-EpCAM antibody therapy candidates in R&D:
EpCAM-Targeted Antibodies Pipeline Review
Product Category: Antibody
This product provides basic information on antibody therapy candidates in research and development targeting EpCAM.
This product consists of:
This product is delivered on the very same day of purchase by e-mail containing competitor and project history reports in pdf format and database credentials. Reports are prepared on the same day.
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent cell-cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc and cyclins A & E.
EpCAM is over-expressed in most of epithelial tumors including colon cancer (97.7%), gastric cancer (90.7%), prostate cancer (87.2%), and lung cancer (63.7%). The high-level expression of EpCAM in solid tumors has made it an attractive target for antibody molecules to treat epithelial cancers, particularly adenocarcinomas. However, EpCAM is also highly prevalent on normal cells.
ADC target options are limited by normal tissue expression. Although EpCAM is an ideal cancer target, it has not been tractable by conventional approaches. Conditional activation can allow ADC technology and T-cell recruiting bispecific antibody technologies to be applied to a wider set of targets. Conventional EpCAM/CD3 bispecific antibodies have shown beneficial clinical outcomes in cancer patients, but have been hampered by dose limiting toxicities due to wide target distribution in normal tissues and potent T cell activation.
The report “EpCAM-Targeted Antibodies Pipeline Review” can be acquired at La Merie Publishing’s online store: https://lamerie.com/report/epcam-targeted-antibodies-pipeline-review/
About La Merie Publishing
La Merie Publishing is an independent business information provider for the biotechnology and pharmaceutical industry. La Merie Publishing prepares brief and full reports. La Merie Publishing products can be purchased in the online store www.lamerie.com and from selected Resellers.
La Merie Publishing offers the service of custom report preparation for corporate clients, including, but not limited to, pipeline analysis reports, drug profiles and any other competitive intelligence elaboration of interest.
SOURCE: La Merie Publishing
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