近日,来自首尔国立大学的研究者们在Cancer Res. 杂志上发表了题为“Dual impact of IGF2 on alveolar stem cell function during tobacco-induced injury repair and development of pulmonary emphysema and cancer”的文章,该研究发现肺泡2型细胞(AT2s)可以刺激肺泡修复或促进肺气肿和癌症,这取决于IGF2的表达水平。
Hye-Jin Boo et al. Dual impact of IGF2 on alveolar stem cell function during tobacco-induced injury repair and development of pulmonary emphysema and cancer. Cancer Res. 2023 Mar 27;CAN-22-3543. doi: 10.1158/0008-5472.CAN-22-3543.