SEATTLE, Nov. 13, 2023 /PRNewswire/ -- Mozart Therapeutics, a leading developer of CD8 Treg Modulators for the treatment of autoimmune and inflammatory diseases, presented preclinical pharmacology and tolerability data for MTX-101,a CD8 Treg modulator at the annual meeting of the American College of Rheumatology being held at the San Diego Convention Center in San Diego, CA.
Presented findings demonstrate:
CD8 Treg are present in rheumatological autoimmune diseases and show decreased expression of functional proteins and reduced responsiveness to stimulation relative to healthy donor CD8 Treg
MTX-101 selectively binds CD8 Treg and enhances their killing of self-reactive CD4 T cells by blocking inhibitory KIR
Enhanced MTX-101 mediated CD8 Treg function prevents self-reactive CD4 T cell expansion and inflammation, without unwanted immune cell activation or increase of pro-inflammatory cytokines
In non-clinical safety studies, MTX-101 was well-tolerated at doses up to 50 mg/kg
Data collectively support the therapeutic potential of MTX-101 for the treatment of autoimmunity including rheumatological diseases
"These results are important because they show the therapeutic potential of MTX-101 and validate the ability MTX-101 to restore the functionality of CD8 Treg in autoimmune diseases and to reestablish immune balance," said Kristine Swiderek, PhD, Chief Scientific Officer at Mozart Therapeutics.
Mozart Therapeutics is focused on developing first-in-class disease-modifying therapies for autoimmune and inflammatory diseases, utilizing a novel approach to restoring immune system function by targeting the CD8 T regulatory network. The company is headquartered in Seattle, WA. For more information visit www.mozart-tx.com and follow the company on LinkedIn @Mozart-tx.