A Randomized, Double-Masked, Placebo-Controlled Study to Assess the Efficacy and Safety of REGN5713-5715 to Reduce Signs and Symptoms of Allergic Conjunctivitis in Participants With Birch Pollen Allergy

This study is researching 2 experimental drugs, REGN5713 and REGN5715, which are called REGN5713-5715 when mixed together (called "study drug") to reduce eye allergy signs and symptoms due to birch tree pollen allergy.
The aim of the study is to see how safe and effective the study drug is at lowering allergic eye signs and symptoms compared with placebo. A placebo looks like a treatment but does not contain any real medicine.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drug
* How much study drug is in the blood at different times
* Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects).

开始日期2024-11-19

申办/合作机构

Regeneron Pharmaceuticals, Inc.

NCT05430919

/ Completed临床2期

A Two-Part Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy of the Anti-Bet v 1 Monoclonal Antibodies to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen

Primary objective: To assess the efficacy of a single dose of the anti- Bet v 1 monoclonal antibodies (mAb(s ) in the reduction of allergic nasal symptoms during an out-of-season birch allergen environmental exposure unit (EEU) challenge in participants receiving REGN5713-5714-5715 versus placebo (Part A)

开始日期2022-08-15

申办/合作机构

Regeneron Pharmaceuticals, Inc.

NCT04709575

/ Completed临床3期

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study Assessing the Efficacy of Anti-Bet v 1 Monoclonal Antibodies to Reduce Symptoms of Seasonal Allergic Rhinitis

The primary objective is to assess the reduction of allergic symptoms as measured by combined symptom and medication score (CSMS) during birch pollen season after a single dose of REGN5713-5714-5715 versus placebo.

开始日期2021-01-14

申办/合作机构

Regeneron Pharmaceuticals, Inc.

100 项与 REGN-5713 相关的临床结果

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100 项与 REGN-5713 相关的转化医学

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100 项与 REGN-5713 相关的专利（医药）

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100 项与 REGN-5713 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
过敏	临床3期	加拿大	Regeneron Pharmaceuticals, Inc.	2024-11-19
结膜炎	临床前	德国	Regeneron Pharmaceuticals, Inc.	2021-01-14
结膜炎	临床前	美国	Regeneron Pharmaceuticals, Inc.	2021-01-14
结膜炎	临床前	丹麦	Regeneron Pharmaceuticals, Inc.	2021-01-14
结膜炎	临床前	比利时	Regeneron Pharmaceuticals, Inc.	2021-01-14
季节性过敏性鼻炎	临床前	德国	Regeneron Pharmaceuticals, Inc.	2021-01-14
季节性过敏性鼻炎	临床前	加拿大	Regeneron Pharmaceuticals, Inc.	2021-01-14
季节性过敏性鼻炎	临床前	比利时	Regeneron Pharmaceuticals, Inc.	2021-01-14
季节性过敏性鼻炎	临床前	丹麦	Regeneron Pharmaceuticals, Inc.	2021-01-14
季节性过敏性鼻炎	临床前	美国	Regeneron Pharmaceuticals, Inc.	2021-01-14

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04709575 (CTgov)	临床3期	季节性过敏性鼻炎 \| 结膜炎	353	REGN5715+REGN5714+REGN5713 (REGN5713-5714-5715)	網簾顧窪選選顧壓壓齋(製餘鑰膚憲獵鬱積鬱願) = 簾簾範築淵鹹顧齋鬱範鑰壓憲獵蓋獵鬱憲夢壓 (鹹願製艱鑰鹹壓壓簾鹹, 選鑰壓構醖簾艱憲蓋淵 ~ 願鏇淵餘繭蓋鹽廠醖鏇) 更多	-	2022-10-27
				Placebo (Placebo Only)	網簾顧窪選選顧壓壓齋(製餘鑰膚憲獵鬱積鬱願) = 獵範憲網鏇餘窪鹹壓夢鑰壓憲獵蓋獵鬱憲夢壓 (鹹願製艱鑰鹹壓壓簾鹹, 網積築膚夢蓋艱醖襯遞 ~ 簾鬱窪構積範鹹願鹹艱) 更多