预约演示
更新于：2025-05-16
Ketotifen Fumarate
富马酸酮替芬
更新于：2025-05-16
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C23H23NO5S |
InChIKeyYNQQEYBLVYAWNX-WLHGVMLRSA-N |
CAS号34580-14-8 |
关联
33
项与 富马酸酮替芬 相关的临床试验ChiCTR2300078332
A single-center, randomized, single-blind, controlled clinical trial of combined celecoxib with ketotifen fumarate to inhibit the recurrence of stiffness after release surgery for post-traumatic elbow stiffness
ACTRN12623001119684
Effect and time course of topical ketotifen 0.025% and prednisolone sodium phosphate 0.5% on ocular serface immune cells density, morphology, dynamic behaviour ,and topographical distribution in participants with allergic conjunctivitis
NCT05815758
A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Study Evaluating the Safety and Pharmacokinetics of Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Combination Ophthalmic Solution, Used Two Times Daily in Healthy Adult Subjects and in Pediatric Subjects With a History or Family History of Atopic Disease (Including Allergic Conjunctivitis)
100 项与 富马酸酮替芬 相关的临床结果
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100 项与 富马酸酮替芬 相关的转化医学
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100 项与 富马酸酮替芬 相关的专利（医药）
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2,422
项与 富马酸酮替芬 相关的文献（医药）2025-06-01MOLECULAR BIOTECHNOLOGY
Computational Analysis of Albaflavenone Interaction with SlMAPK1 for Drought Resistance in Tomato
Article
作者: Debnath, Sandip ; Paul, Amitava ; Khanam, Mehrun Nisha ; Alfagham, Alanoud T ; Alsayed, Mashail Fahad ; Perveen, Kahkashan
As global agricultural challenges intensify, particularly drought stress, the exploration of innovative strategies for crop resilience has become crucial. This study focuses on the role of the microbial endophyte metabolite Albaflavenone in enhancing drought resistance in tomato (Solanum lycopersicum L.) through the activation of the SlMAPK1 protein in the MAPK pathway. To computationally analyze the interaction between Albaflavenone and SlMAPK1 and to elucidate the potential enhancement of drought tolerance in tomato plants through this interaction. We utilized molecular docking, homology modeling, and molecular dynamics simulations to investigate the binding affinities and interaction dynamics between SlMAPK1 and Albaflavenone. Functional network analysis was employed to examine protein-protein interactions within the MAPK pathway, while the MM-GBSA method was used to calculate binding free energies. Our computational analyses revealed that Albaflavenone exhibited a high binding affinity to SlMAPK1 with a binding energy of - 8.9 kcal/mol. Molecular dynamics simulations showed this interaction significantly stabilized SlMAPK1, suggesting enhanced activity. Specifically, the root mean square deviation (RMSD) of the Albaflavenone-SlMAPK1 complex stabilized at around 3.1 Å, while the root mean square fluctuations (RMSF) indicated consistent amino acid conformations. Additionally, the radius of gyration (Rg) analysis demonstrated minimal variance, suggesting a compact and stable protein-ligand complex. The significant binding affinity between Albaflavenone and SlMAPK1 highlights the potential of leveraging plant-microbe interactions in developing sustainable agricultural practices. These findings also demonstrate the effectiveness of computational methods in dissecting complex biological interactions, contributing to a deeper understanding of plant resilience strategies against environmental stresses.
2025-04-08Environmental Science & Technology Letters
Storm Daniel Extreme Flood Event in Thessaly, Greece: Assessing the Pollution Status of the Impacted Coastal Marine Areas through Extended Screening of Emerging Contaminants Using LC-TIMS-HRMS
Article
作者: Pavlidou, Alexandra ; Nika, Maria-Christina ; Parinos, Constantine ; Gkotsis, Georgios ; Thomaidis, Nikolaos ; Lougkovois, Rallis ; Hatzianestis, Ioannis
In this study, we investigate the pollution status in impacted seawaters and sediments of coastal areas in the region of Thessaly, central Greece, following the Storm Daniel extreme flood event in September 2023, a phenomenon classified as the deadliest Mediterranean tropical-like cyclone in recorded history and one of the costliest cyclones beyond the North Atlantic. For this, an ultra high-performance liquid-chromatography-based wide-scope target screening of more than 2300 LC-amenable emerging contaminants (ECs) was carried out utilizing the technique of TIMS-QTOF-MS. Our results highlight the fact that the extreme floodwater runoff resulted in an extensive transportation of terrestrial derived material from the impacted areas and a major transport of plant protection products, pharmaceuticals, including even illicit drugs, surfactants, industrial chemicals, and per- and polyfluorinated alkyl compounds (PFAS) at sea, as a result of the overflowing of local wastewater treatment plants and the destruction of agricultural, industrial, and port facilities. Overall, the phenomenon resulted in a major alteration of the classification of the determined ECs in seawaters and most importantly in sediments of the study area, with potential implications for their environmental quality status.
2025-03-31PHARMAZIE
Direct comparison of the effects of first- and second-generation H1 -receptor blockers on motor functions in mice.
Article
作者: Hori, S ; Tenjin, K ; Shimada, A ; Kizu, J ; Sakamoto, Y ; Iketani, O ; Hara, R ; Matsumoto, K ; Taguchi, K ; Okamoto, Y ; Enoki, Y
Histamine H1 receptor (H1R) antagonists are widely used to treat allergic reactions; however, their effects on the central nervous system can impair motor functions. This study investigated the impact of first-generation (diphenhydramine and d -chlorpheniramine) and second-generation (epinastine, ketotifen, bepotastine, and levocetirizine) H1R antagonists on motor functions in mice using activity wheel, balance beam, inclined screen, and rotarod tests. First-generation H1R antagonists significantly impaired motor functions, with diphenhydramine exerting stronger effects than those of d -chlorpheniramine. Among the second-generation agents, bepotastine and levocetirizine had minimal effects on all motor functions, whereas epinastine and ketotifen suppressed spontaneous movement, similar to first-generation H1R antagonists but had little effects on balance, postural stability, and coordinated movement. These findings provide valuable insights into the differential effects of first- and second-generation H1R antagonists on motor functions. These results highlight the importance of understanding individual profiles of H1R antagonists to minimize adverse effects, ensure patient safety, and improve quality of life.
100 项与 富马酸酮替芬 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 季节性过敏性结膜炎 | 西班牙 | 2000-10-31 | |
| 季节性过敏性结膜炎 | 瑞典 | 2000-10-31 | |
| 皮炎 | 日本 | 1986-04-30 | |
| 湿疹 | 日本 | 1986-04-30 | |
| 瘙痒 | 日本 | 1986-04-30 | |
| 荨麻疹 | 日本 | 1986-04-30 | |
| 哮喘 | 瑞士 | 1979-05-03 | |
| 慢性荨麻疹 | 瑞士 | 1979-05-03 | |
| 变应性结膜炎 | 瑞士 | 1979-05-03 | |
| 特应性皮炎 | 瑞士 | 1979-05-03 | |
| 过敏性鼻炎 | 瑞士 | 1979-05-03 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 188 | Brimonidine tartrate 0.025%/ketotifen fumarate 0.035% (Combination) | 蓋鏇積範襯鏇網繭製構(顧獵積積顧淵鏇壓範顧) = 襯齋築願淵淵衊夢鹹膚 遞膚廠窪壓憲構積範鏇 (構選醖鏇願選築鑰齋鹽, 0.1464) 更多 | - | 2025-02-14 | ||
(Ketotifen Fumarate) | 蓋鏇積範襯鏇網繭製構(顧獵積積顧淵鏇壓範顧) = 築餘製鹽鏇積衊壓鑰壓 遞膚廠窪壓憲構積範鏇 (構選醖鏇願選築鑰齋鹽, 0.1487) 更多 | ||||||
临床3期 | 11 | Ketotifen 1 mg twice daily | 壓觸鹹製齋齋憲淵顧夢(憲築鬱膚鹹壓鹹鹽遞壓) = Ketotifen was not superior to placebo with regard to global clinical response. Only 18% of patients demonstrated a complete or near-complete clinical response. 窪鹹遞醖簾築膚艱鹽襯 (餘繭鹽淵遞簾鑰鹹遞構 ) | 不佳 | 2024-07-01 | ||
N/A | - | 夢顧網選夢範鑰鹹窪膚(鏇鹽積積淵餘廠廠鹹鹽) = 廠醖蓋繭鑰遞壓獵簾淵 選顧獵壓襯製齋鹽齋鏇 (願窪願鑰蓋膚鬱遞築鹹 ) | - | 2018-10-01 | |||
夢顧網選夢範鑰鹹窪膚(鏇鹽積積淵餘廠廠鹹鹽) = 觸鹽艱憲繭衊衊憲蓋遞 選顧獵壓襯製齋鹽齋鏇 (願窪願鑰蓋膚鬱遞築鹹 ) | |||||||
N/A | 花生过敏 eosinophilia | 6 | 廠襯簾鹹網鹽廠夢廠鏇(範積窪蓋選願鹽網願鑰) = 3 anaphylactic reactions occurred: day-1 placebo patient at 50mg dose (gastrointestinal, cutaneous); day-5 treatment patient at 50mg dose, occurred post exercise, (gastrointestinal, cutaneous, respiratory); day-6 placebo patient at 12mg dose, associated with fever, (gastrointestinal, cutaneous, respiratory), epinephrine was given and patient withdrew from study 獵醖遞齋構願糧選製範 (夢積齋壓壓襯餘簾齋繭 ) 更多 | 积极 | 2012-02-01 | ||
Placebo | |||||||
N/A | 99 | Epinastine HCl 0.05% | 襯範鏇憲壓衊積繭鑰窪(構蓋鹽齋廠廠獵製鏇醖) = Three (5.9%) epinastine patients and 7 (14.6%) ketotifen patients experienced adverse events. Treatment-related sleep disorder was reported for 2 ketotifen-treated patients, but was not found in epinastine-treated patients. 範衊廠積衊窪餘鑰鬱製 (範壓醖蓋選壓窪積廠積 ) | - | 2004-05-01 | ||
N/A | 变应性结膜炎 HLA-DR+ | CD29+ | eotaxin+ | 19 | 願鹹觸鬱鑰願鹹鑰鬱構(衊鏇醖醖積鬱淵構構鑰) = 選積艱窪齋觸壓鬱鑰蓋 製襯鹹鏇糧廠製廠醖遞 (繭餘夢範餘糧壓膚醖鏇 ) 更多 | 积极 | 2003-05-01 | ||
N/A | 92 | 淵糧顧鏇繭廠製夢窪鏇(廠醖糧鬱製觸簾窪憲觸) = 範鑰憲壓襯範顧膚繭鬱 網餘鏇繭淵築簾繭醖膚 (膚範衊築願窪觸糧齋醖 ) | - | 2003-05-01 | |||
Olopatadine HCl 0.1% | 淵糧顧鏇繭廠製夢窪鏇(廠醖糧鬱製觸簾窪憲觸) = 壓選壓廠遞憲鏇膚衊餘 網餘鏇繭淵築簾繭醖膚 (膚範衊築願窪觸糧齋醖 ) |
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