This paper discuss about effectiveness of two-dose vaccination with mRNA COVID-19 vaccines against COVID-19-associated hospitalizations among immunocompromised adults.The linked report evaluated immunocompetent and immunocompromised adults who were hospitalized with COVID-19 infection at 187 hospitals in nine US states between Jan. and Sept. 2021.This report suggests that immunocompromised persons, including solid organ transplant recipients, benefit from mRNA COVID- 19 vaccination but are less protected from severe COVID-19 outcomes than immunocompetent persons.This report underscores the urgent need for further study of the optimal prevention and management of COVID-19 infection focused in the solid organ transplant population.