An Open Prospective Randomized Clinical Study of the Effectiveness, Tolerability and Safety of a Single Intraperitoneal Use of the Drug "Prospidelong, Powder for the Preparation of a Gel for Topical Use, 1000 mg in Vials, Package No. 1" in Patients With Disseminated Gastric Cancer, Phase I-II

It is planned to conduct an open-label, prospective, randomized clinical study of the efficacy, tolerability and safety of a single intraperitoneal administration of the investigational drug Prospidelong at a dose of 4000 mg (2000 mg in terms of prospidium chloride) in patients with disseminated gastric cancer.
In total, the study plans to include 120 patients aged 18 to 75 years inclusive, including 60 patients in the study group and 60 in the comparison group. The study consists of daily examination of patients throughout the entire period of hospitalization and subsequent visits.

开始日期2025-03-19

申办/合作机构

Unitary Enterprise UNITEHPROM BSU

100 项与 Prospidium chloride 相关的临床结果

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100 项与 Prospidium chloride 相关的转化医学

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100 项与 Prospidium chloride 相关的专利（医药）

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224

项与 Prospidium chloride 相关的文献（医药）

2024-02-01·Journal of Mathematical Chemistry

Identification of potential oral cancer drugs as Bcl-2 inhibitors from known anti-neoplastic agents through docking studies

作者: Pal, Debnath ; Raychaudhury, Chandan ; Srinivasan, Shreyaa

Oral Cancer is one of the major killers in India and of global concern.An attempt has been made here to identify small mol. inhibitors of Bcl-2 (B-cell lymphoma 2) protein through docking studies in search of new oral cancer drugs from a curated set of 276 known anti-neoplastic agents obtained from PubChem.The Bcl-2 protein (PDB id:6QGH), being complexed with ligand ABT-263, has been detached from the complex.The ligand-free protein and 276 compounds have been prepared for docking studies using corresponding tools available in Discovery Studio (DS), ver.4.1.The 276 compounds have been docked on the first site of the protein using LibDock docking program available in DS.By considering Methotrexate as the reference compound (LibDock score: 114.76), we have identified 25 compounds as the most potential oral cancer drugs having LibDock scores greater than 100.Another set of 114 compounds with LibDock scores between 80 and 100 have also been identified as the next set of potential drug candidates and some of them show anti-apoptosis properties.Two other compounds with LibDock scores below 80 have been identified for comparative analyses with some high-scoring compoundsThe docking results have been given in tables and pictures (screenshots) of the docked poses of selected compounds have been shown to illustrate the findings.Finally, the most suitable potential compounds have been identified by applying Lipinski′s Rule of 5.The present approach using known anti-neoplastic agents is believed to help discover potential anti-oral cancer drug candidates.

2021-09-01·Russian Journal of Applied Chemistry

Synthesis of Selenium Nanoparticles Stabilized with Sodium Carboxymethylcellulose for Preparation of a Long-Acting Form of Prospidine

作者: Kokhan, A. V. ; Alinovskaya, V. A. ; Sarymsakov, A. A. ; Yurkshtovich, T. L. ; Bychkovskii, P. M. ; Golub, N. V. ; Yurkshtovich, N. K. ; Rashidova, S. Sh. ; Turakulov, F. M. ; Solomevich, S. O. ; Yunusov, Kh. E.

Stable selenium nanoparticles were synthesized in a sodium CM-cellulose (Na-CMC) solution with a degree of substitution of 0.85 and an average molar weight of 250 000.The shape and size of selenium nanoparticles were determined by dynamic light scattering and UV spectroscopy.It was found that the nanoparticles coated with Na-CMC are stable upon storage for 28 days.A significant prolongation of the release of the prospidine antitumor agent from stabilized nanoparticles has been shown.Broad spectrum drugs, in particular, anticancer drugs and drugs that compensate for selenium deficiency in the body can be produced based on the selenium nanoparticles coated with Na-CMC.

2021-06-01·Materials Letters

Millimeter-sized chitosan/dextran phosphate capsules and calcium/dextran phosphate beads for regulating prospidine release

作者: Aleksandra V. Cherkasova ; Uladzislau E. Aharodnikau ; Pavel M. Bychkovsky ; Daria A. Salamevich ; Tatiana L. Yurkshtovich ; Sergey O. Solomevich

In this study, we synthesized calcium/dextran phosphate beads (Ca-DP) by ionic gelation method and chitosan/dextran phosphate capsules (CS-DP) by forming polyelectrolyte complexes as carriers for prospidine delivery.The conditions for the formation of beads and capsules were established and their morphol. was investigated.The release behavior of prospidine from the Ca-DP and CS-DP was investigated in vitro in different pH and a depression of initial burst release of the drug was shown.The cytotoxicity evaluation indicated that both Ca-DP and CS-DP displayed high cell viability and the prospidine-loaded samples probably due to the prolonged release induced apoptosis over a longer period of time compared to pure drug.Therefore, such pH-responsive Ca-DP and CS-DP could be promising candidates as drug delivery systems.

100 项与 Prospidium chloride 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	Prospidium chloride	-	-

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适应症	最高研发状态	国家/地区	公司	日期
转移性胃癌	临床3期	白俄罗斯	Unitary Enterprise UNITEHPROM BSU	2025-03-19

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


EULAR2003	N/A	类风湿关节炎	110	Prospidin + Methotrexate	餘膚糧壓鬱餘觸願網鬱(築築艱構醖鹹繭餘夢齋) = 繭廠衊餘製獵選簾繭範簾觸膚餘顧壓觸襯鏇築 (壓鬱窪艱鏇蓋艱糧願鹹 ) 更多	-	2003-06-18
				Methotrexate	餘膚糧壓鬱餘觸願網鬱(築築艱構醖鹹繭餘夢齋) = 鑰膚淵夢願製蓋繭衊構簾觸膚餘顧壓觸襯鏇築 (壓鬱窪艱鏇蓋艱糧願鹹 ) 更多