An Open Prospective Randomized Clinical Study of the Effectiveness, Tolerability and Safety of a Single Intraperitoneal Use of the Drug "Prospidelong, Powder for the Preparation of a Gel for Topical Use, 1000 mg in Vials, Package No. 1" in Patients With Disseminated Gastric Cancer, Phase I-II

It is planned to conduct an open-label, prospective, randomized clinical study of the efficacy, tolerability and safety of a single intraperitoneal administration of the investigational drug Prospidelong at a dose of 4000 mg (2000 mg in terms of prospidium chloride) in patients with disseminated gastric cancer.
In total, the study plans to include 120 patients aged 18 to 75 years inclusive, including 60 patients in the study group and 60 in the comparison group. The study consists of daily examination of patients throughout the entire period of hospitalization and subsequent visits.

开始日期2024-06-01

申办/合作机构

Unitary Enterprise UNITEHPROM BSU

100 项与 Prospidium chloride 相关的临床结果

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100 项与 Prospidium chloride 相关的转化医学

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100 项与 Prospidium chloride 相关的专利（医药）

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项与 Prospidium chloride 相关的文献（医药）

2001-01-01·Bulletin of Experimental Biology and Medicine4区 · 医学

New experimental model of multiple myeloma.

4区 · 医学

Article

作者: A. R. Kalinina ; G. B. Telegin ; A. A. Ovsepyan ; N. A. Ponomarenko ; S. G. Homeriki ; V. V. Tsybenko ; S. V. Smirnov

NSO/1 (P3x63Ay 8Ut) and SP20 myeloma cells were inoculated to BALB/c OlaHsd mice. NSO/1 cells allowed adequate stage-by-stage monitoring of tumor development. The adequacy of this model was confirmed in experiments with conventional cytostatics: prospidium and cytarabine caused necrosis of tumor cells and reduced animal mortality.

1984-01-01·Revista espanola de oncologia

Tratamiento con cloruro de prospidio intratumoral del cancer de mama inducido con N-nitrosometilurea en la rata.

Article

作者: Urcia, M ; Pérez-López, F R ; Guillén, V ; Hergueta, J ; Leal, M C ; Lafarga, L

Wistar rats bearing N-nitrosomethylurea-induced mammary tumors received intratumoral injections of prospidium chloride or saline. Each tumor with 30-100 mm2 (the product of the two largest perpendicular diameters) received 20 mg of prospidium chloride diluted in 100 microliter of saline, and increasing amounts of 20 mg of the product in the same volume for every additional 100 mm2 or fraction of tumor. After a week the treatment was repeated in the same way. Control rats received only saline without prospidium chloride. No significant differences were observed regarding the tumor area, total tumor area/rat, and body weight when comparing the rats receiving prospidium chloride and the control rats. Prospidium chloride does not show any direct oncolytic effect upon the experimental model employed.

1984-01-01·Voprosy onkologii

Chuvstvitel'nost' épidermoidnogo raka legkikh in vitro k tsitostatikam v zavisimosti ot stepeni differentsiatsii opukholi.

Article

作者: Murnietse, E V ; Plegere, D A ; Berzin'sh, Iu A ; Zitare, I Ia ; Grants, E A

In vitro sensitivity of epidermoid lung carcinoma to chemotherapeutic agents in short-term cultures versus degree of tumor differentiation was evaluated for the following drugs: 5-fluorouracil, methotrexate, olivomycin, bleomycin, carminomycin, adriablastin, prospidium chloride, vincristine, thiophosphamide, novembichine and photrine. The results of the investigation using resected material from 77 cases of histologically confirmed epidermoid lung carcinoma failed to establish any relationship between the parameters under study for all above drugs except vincristine. However, tumors showing similar levels of differentiation demonstrated different sensitivity to certain drugs.

100 项与 Prospidium chloride 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	Prospidium chloride	-	-

研发状态

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适应症	最高研发状态	国家/地区	公司	日期
转移性胃癌	临床3期	白俄罗斯	Unitary Enterprise UNITEHPROM BSU	2024-06-01

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


EULAR2003	N/A	类风湿关节炎	110	Prospidin + Methotrexate	醖淵網淵網餘衊襯積窪(餘鬱鏇艱夢觸鏇繭積淵) = 鑰觸積襯艱淵窪遞築衊繭鑰簾衊構顧齋獵鑰築 (遞願膚夢鹹繭選淵構淵 ) 更多	-	2003-06-18
				Methotrexate	醖淵網淵網餘衊襯積窪(餘鬱鏇艱夢觸鏇繭積淵) = 獵鹽餘淵選顧簾蓋壓衊繭鑰簾衊構顧齋獵鑰築 (遞願膚夢鹹繭選淵構淵 ) 更多