GS-17(GS-17) - 在研适应症：实体瘤_专利_临床

概要

基本信息

药物类型

双特异性抗体

别名

靶点-

作用方式-

作用机制-

治疗领域

肿瘤

在研适应症

实体瘤

非在研适应症-

原研机构

Gensun Biopharma, Inc.

在研机构

Gensun Biopharma, Inc.

非在研机构-

权益机构

苏州泽璟生物制药股份有限公司

Gensun Biopharma, Inc.

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 GS-17 相关的临床结果

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100 项与 GS-17 相关的转化医学

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100 项与 GS-17 相关的专利（医药）

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2

项与 GS-17 相关的文献（医药）

2015-04-01·The Journal of Antibiotics4区 · 医学

Two new amides from a halotolerant fungus, Myrothecium sp. GS-17

4区 · 医学

Article

作者: Pan, Huaqi ; Yuan, Chunmao ; Zhang, Songya ; Guan, Liping ; Li, Zhanlin ; Liu, Guyue ; Bai, Jiao ; Zhu, Jing ; Wu, Xin ; Liu, Tao ; Hua, Huiming

Two new amides, named N-acetyl-2,4,10,17-tetrahydroxyheptadecylamine (1) and N-acetyl-3,5,11,18-tetrahydroxyoctadecyl-2-amine (2), were isolated from a halotolerant fungus, Myrothecium sp. GS-17. Their structures were identified on the basis of spectroscopic characteristics. The cancer cell cytotoxicities of two compounds were evaluated, and compound 2 exhibited weak cytotoxicity in HL-60 cell line.

Molecules3区 · 化学

Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17

3区 · 化学

ArticleOA

作者: Bai, Jiao ; Guan, Li-Ping ; Li, Zhan-Lin ; Pan, Hua-Qi ; Wu, Xin ; Hua, Hui-Ming ; Liu, Tao ; Zhang, Song-Ya ; Zhu, Jing

Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1- hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.

100 项与 GS-17 相关的药物交易

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