预约演示

更新于：2025-03-20

Lycorine Hydrochloride Thioester

盐酸石蒜碱硫酯

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制-

治疗领域

感染

在研适应症

手足口病

非在研适应症-

原研机构

山东达因海洋生物制药股份有限公司

在研机构

山东达因海洋生物制药股份有限公司

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)临床1期

特殊审评-

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关联

项与盐酸石蒜碱硫酯相关的临床试验

CTR20244667

/ Recruiting临床1期

注射用盐酸石蒜碱硫酯在中国健康受试者中单次给药和多次给药剂量递增的安全性、耐受性和药代动力学的I期临床研究

评价注射用盐酸石蒜碱硫酯在成年健康受试者中单次和多次给药后的安全性及耐受性；评价注射用盐酸石蒜碱硫酯在成年健康受试者中单次和多次给药后的人体药代动力学特征。确定注射用盐酸石蒜碱硫酯后续研究推荐剂量，为后续临床试验给药方案和给药剂量提供依据。

开始日期2024-12-26

申办/合作机构

山东达因海洋生物制药股份有限公司

100 项与盐酸石蒜碱硫酯相关的临床结果

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100 项与盐酸石蒜碱硫酯相关的转化医学

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100 项与盐酸石蒜碱硫酯相关的专利（医药）

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项与盐酸石蒜碱硫酯相关的文献（医药）

2019-05-01·Phytochemical Analysis2区 · 生物学

Discovery and characterisation of lycorine‐type alkaloids in Lycoris spp. (Amaryllidaceae) using UHPLC‐QTOF‐MS

2区 · 生物学

Article

作者: Ruan, Hanli ; Jiang, Hongliang ; Li, Aiqian ; Du, Zhifeng ; Feng, Yulin ; Liao, Mei

AbstractIntroductionLycorine, one of the most common alkaloids in Lycoris spp., is believed to possess pharmacological activity.ObjectiveTo discover and identify lycorine‐type alkaloids in the crude extracts of bulbs from six Lycoris spp. by ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry (UHPLC‐QTOF‐MS) detection.MethodologyA qualitative analytical method with a data mining strategy was utilised. Based on the fragmentation patterns of standards investigated in positive tandem mass spectrometry (MS/MS) mode, the fragmentation rules of lycorine‐type alkaloids were summarised. These types of alkaloids were additionally classified as different subtypes based on structural features and MS/MS fragmentation patterns, and the diagnostic ions for characterisation of different subtypes of alkaloids were designated.ResultsThirty‐seven lycorine type alkaloids, including 16 previously undescribed compounds, were efficiently screened out and tentatively identified from the crude extracts of six Lycoris spp. Lycoris sprengri may be a preferable species for studying or extracting lycorine‐type alkaloids because of elevated relative concentrations and highest diversity of alkaloids.ConclusionThe UHPLC‐QTOF‐MS and MS/MS data‐mining strategy proved useful for the detection and tentative identification of lycorine‐type alkaloids in bulbs of Lycoris spp. and could be extended to other Amaryllidaceae genera. The consequent profiling of the lycorine‐type alkaloids will be useful in the quality control of raw materials of Lycoris species and the exploration of superior species.

2014-03-01·Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology

[Narcissus].

Article

作者: Miyazaki, Shigeru

1975-12-01·Planta Medica

PHYTOCHEMICAL INVESTIGATION OFHIPPEASTRUM VITTATUMGROWING IN EGYPT

Article

作者: Ali, A. ; Mesbah, M. ; Mohgazi, A.

100 项与盐酸石蒜碱硫酯相关的药物交易

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