更新于：2024-11-30
Esflurbiprofen
艾司氟比洛芬
更新于：2024-11-30
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (2015-09-28), |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C15H13FO2 |
InChIKeySYTBZMRGLBWNTM-JTQLQIEISA-N |
CAS号51543-39-6 |
关联
15
项与 艾司氟比洛芬 相关的临床试验Efficacy of S-flurbiprofen Plaster in Moderate to Severe Knee Osteoarthritis: A Randomized Controlled Trial
Efficacy of Esflurbiprofen transdermal patch for postoperative analgesia in multilevel posterior lumbar spinal fusion: A randomized controlled trial
The comparison of pain relief efficacy of s-flurbiprofen plaster transdermal patch 20 mg at acupuncture points and transdermal patch 40 mg applied at knee in primary knee osteoarthritis: an open-label, randomized, controlled, non-inferiority trial
100 项与 艾司氟比洛芬 相关的临床结果
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100 项与 艾司氟比洛芬 相关的转化医学
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100 项与 艾司氟比洛芬 相关的专利（医药）
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106
项与 艾司氟比洛芬 相关的文献（医药）2024-12-01SCIENCE OF THE TOTAL ENVIRONMENT
Evaluating a vertical greening system mesocosm for kitchen greywater treatment: Comparison among vegetation species in water consumption, biomass growth and pollutants uptake and removal
Article
作者: Celadon, Nicola ; Borin, Maurizio ; Dal Ferro, Nicola ; Ferro, Nicola Dal
The escalating climate imbalance, coupled with rising water demands in rapidly expanding urban areas, is forcing scientists and policymakers to seek alternative strategies for efficient water resource management. Nature Based Solutions (NBS) are gaining prominence due to their ability to provide multiple ecosystem services. However, the quantification of benefits and drawbacks mediated by different vegetation species remains inadequate. In this study, we investigated the performance of a pot-based vertical greening system (VGS) designed to integrate the functions of green facades with those of treatment wetlands. The VGS was vegetated with Mentha aquatica L. (hereafter Mentha), Oenanthe javanica (Blume) DC. (hereafter Oenanthe) and Lysimachia nummularia L. (hereafter Lysimachia), and their respective effects on water balance and mass removal of common greywater pollutants were compared. Results indicated that VGS lines vegetated with Oenanthe and Mentha exhibited comparable pollutant removals. Oenanthe showed a preference for greywater that had already undergone partial treatment, while Mentha was not affected by any pollutant load in water removal -48.1 % of total inflow- and in nutrients uptake in aboveground biomass -14.3 % N and 7 % P- due to sustained and robust growth, outperforming Oenanthe and Lysimachia. This has suggested the potential use of Oenathe in combination with Mentha for enhanced performances, particularly given Oenanthe's rapid growth in the early season and high biomass and nitrogen content following initial greywater treatment.
2024-08-13Cureus Journal of Medical Science
Efficacy of S-Flurbiprofen Plaster for Analgesia Following Total Hip Arthroplasty
Article
作者: Mitani, Shigeru ; Namba, Yoshifumi ; Kawamoto, Toyohiro ; Miyake, Yoshiaki ; Furuichi, Shuro ; Umehara, Norifumi
PURPOSE:
S-flurbiprofen (SFP) plaster, a non-steroidal anti-inflammatory drug preparation that penetrates effectively into deep tissue, is currently used as a conservative treatment for osteoarthritis. We investigated the analgesic and adverse effects of SFP plaster after total hip arthroplasty (THA).
METHODS:
A retrospective comparative study identified 100 patients who underwent primary THA in our department. Group A consisted of 50 patients who received the selective cyclooxygenase-2 inhibitor celecoxib for 14 days after surgery, while Group B consisted of 50 patients who received SFP plaster for 14 days after surgery. We noted the numerical rating pain intensity scale (NRS) score, body temperature, and adverse effects of the analgesics.
RESULTS:
Groups A and B showed no significant difference in NRS scores (p > 0.05). The body temperature was significantly higher in Group B than in Group A on days one, two, three, and five (p < 0.01). In Group A, two patients (4%) showed drug-induced renal dysfunction, and one patient (2%) showed gastrointestinal disturbance. Patients in Group B showed no systemic or local adverse effects.
CONCLUSIONS:
The application of SFP plaster after THA provided an analgesic effect similar to that obtained with oral celecoxib without causing obvious side effects. Applying an SFP plaster may be an effective solution for postoperative analgesia.
2023-09-02Cureus
Effectiveness and Adherence Rate of S-flurbiprofen Plaster for the Pain Management of Patients With Moderate and End-Stage Knee Osteoarthritis
Article
作者: Takeshita, Katsushi ; Takahashi, Tsuneari ; Iguchi, Masaki
BACKGROUND:
S-flurbiprofen plaster (SFPP) is highly skin permeable and represents a new conservative treatment for knee osteoarthritis (KOA) that can attain considerably higher concentrations in the synovium than topical flurbiprofen. To date, no study has investigated the efficacy and adherence rate of SFPP in patients with end-stage KOA. This study aimed to compare the effectiveness and adherence rate of SFPP for pain management in patients with moderate and end-stage KOA.
METHODS:
This retrospective study included a total of 118 patients with KOA (Kellgren-Lawrence classification grades II (n = 29), III (n = 32), and IV (n = 57)). The difference in SFPP use rate, adverse drug reactions rate, whether 50% pain relief occurred, and the percentage of patients who underwent surgical treatment were calculated.
RESULTS:
The overall SFPP use rate at one year was 61.0% (88.1% at less than one month, 79.7% at three months, and 61.0% at six months), with no significant differences among Kellgren-Lawrence grade II, III, and IV groups (p = 0.538). Adverse drug reactions such as skin rash (n = 23), skin irritation (n = 8), and gastrointestinal disorders (n = 2) were observed. The one-year SFPP use rate was significantly lower in patients in whom these side effects occurred but did not decrease in patients in whom only a skin rash occurred. Overall, 19 patients underwent surgery after discontinuation of SFPP use. Surgery was statistically selected more by the "over 71 years of age" group (p = 0.038) and the "ineffective" group (p = 0.007).
CONCLUSION:
SFPP exerts a comparable therapeutic effect even in end-stage KOA and may be an effective treatment option. Even if patients have end-stage KOA, there are cases in which the patient's background does not allow for surgery positively, such as high perioperative risk or desire for conservative treatment. In such cases, SFPP may be an effective treatment option worth trying.
100 项与 艾司氟比洛芬 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 骨关节炎 | 日本 | 2015-09-28 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 运动损伤 | 临床2期 | 德国 | 2021-05-20 | |
| 挫伤 | 临床2期 | 德国 | 2021-05-20 | |
| 软组织损伤 | 临床2期 | 德国 | 2021-05-20 | |
| 扭伤和拉伤 | 临床2期 | 德国 | 2021-05-20 | |
| 急性疼痛 | 临床2期 | 美国 | 2016-07-01 | |
| 踝损伤 | 临床2期 | 美国 | 2016-07-01 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 200 | (Active Arm) | 壓夢窪鹽憲簾製膚壓築(衊衊鹹遞簾醖觸艱淵獵) = 淵網廠齋獵願網糧製觸 憲膚糧築艱獵餘觸艱製 (顧獵襯壓鑰繭壓積蓋積, 簾簾齋築積衊簾獵獵構 ~ 壓艱鑰夢獵醖願壓網蓋) 更多 | - | 2023-09-28 | ||
(Control Drug) | 壓夢窪鹽憲簾製膚壓築(衊衊鹹遞簾醖觸艱淵獵) = 餘艱襯觸網鹹窪網觸願 憲膚糧築艱獵餘觸艱製 (顧獵襯壓鑰繭壓積蓋積, 構糧廠網積齋獵遞鬱顧 ~ 築廠膚膚鹽廠鹹製艱製) 更多 |
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