预约演示
更新于：2025-04-19
Esflurbiprofen
艾司氟比洛芬
更新于：2025-04-19
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2015-09-28), |
最高研发阶段(中国)- |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C15H13FO2 |
InChIKeySYTBZMRGLBWNTM-JTQLQIEISA-N |
CAS号51543-39-6 |
关联
20
项与 艾司氟比洛芬 相关的临床试验TCTR20240929002
Efficacy of Esflurbiprofen transdermal patch for postoperative analgesia in multilevel posterior lumbar spinal fusion: A randomized controlled trial
NCT06866613
Randomized, Controlled, Double-blind, Multi-center Trial to Evaluate the Efficacy and Safety of an Esflurbiprofen Topical System (EFTS) vs. Placebo in the Local Symptomatic and Short-term Treatment of Pain in Ankle Sprains.
NCT06870422
A Randomized, Four-way Change-over Study to Evaluate the Effect of Moderate Heat, Occlusion, and Moderate Exceise on the Pharmacokinetics and Tolerability of the Esflurbiprofen Topical System in Healthy Volunteers
100 项与 艾司氟比洛芬 相关的临床结果
登录后查看更多信息
100 项与 艾司氟比洛芬 相关的转化医学
登录后查看更多信息
100 项与 艾司氟比洛芬 相关的专利（医药）
登录后查看更多信息
498
项与 艾司氟比洛芬 相关的文献（医药）2025-02-17ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Highly Efficient Chiral Separation Based on Alkali‐proof Protein Immobilization by Covalent Organic Frameworks
Article
作者: Yang, Mingfang ; Zhang, Sainan ; Zheng, Yunlong ; Guo, Jinbiao ; Yu, Jiangyue ; Zhang, Zhenjie ; Cai, Yuqing ; Chen, Yao ; Zuo, Along
Abstract:
Chiral separation plays a pivotal role in both practical applications and industrial productions. However, traditional chiral stationary phases (CSPs) exhibit inherent instability in alkaline environments, presenting a significant challenge despite their importance. Herein, basophilic alcalase is creatively developed to fabricate ultrastable protein‐based CSPs that can efficiently work under alkaline conditions. An in‐depth theoretical simulation is conducted to unveil the unique three‐dimensional conformation of alcalase, showing selective affinity towards various enantiomers of chiral amino acids and drugs, especially acidic substrates. Subsequently, an in situ assembly strategy is used to immobilize alcalase within a hydrazone‐linked covalent organic framework (COF) platform. The generated protein‐based CSPs enable successful baseline separation (Rs≥1.50) for various value‐added compounds (e.g., non‐steroidal drug, RS‐flurbiprofen; nucleotide analog, RS‐tenofovir) via high‐performance liquid chromatography, surpassing the commercial chiral column. Furthermore, a systematic study reveals that increasing hydrophilicity and pore sizes of COFs can enhance the separation performance. Remarkably, the obtained CSPs demonstrated exceptional durability, maintaining performance for >2,400 runs. This study provides a new member to the protein library for CSPs, and represents an innovative and effective platform for CSPs with immense potential for the enantioseparation of acidic drugs.
2025-02-01ANALYTICA CHIMICA ACTA
Preparation of novel chiral stationary phases based on chiral metal-organic cages enable extensive HPLC enantioseparation
Article
作者: Luo, Aiqin ; Duan, Juntao ; Tang, Bo ; Wang, Wei ; Zhang, Yukui ; Wang, Zhen ; Sun, Liquan ; Liang, Axin
BACKGROUND:
The metal organic cages (MOCs) are an emerging type of porous material that has attracted considerable research interest due to their unique properties, including good stability and well-defined intrinsic cavities. The chiral MOCs with porous structures have broad application prospects in enantiomeric recognition and separation. However, there are almost no relevant reports on chiral MOCs as chiral stationary phases (CSPs) for enantioseparation by high-performance liquid chromatography (HPLC).
RESULTS:
Here, we report for the first time, the chiral MOCs, MOC-PA was "wrapped" onto the silica gel to create a novel HPLC CSP of chiral MOC-PA@SiO2 through wrapped in net method. There are 24 and 20 chiral compounds or chiral drugs, including alcohols, diols, esters, ketones, alkene, epoxides, ethers, organic acids, phenols and amines, were enantioseparated by vary degrees on MOC-PA@SiO2 packed column under both normal phase (NP) and reversed phase (RP) modes, respectively. Furthermore, compared with commercial Chiralpak AD-H and Chiralcel OD-H columns, the MOC-PA@SiO2 packed column exhibits well chiral separation complementarity to them. It can separate some racemates that unable to be or not to be well separated by the Chiralpak AD-H and Chiralcel OD-H columns. Besides, there are four positional isomers were also well separated by MOC-PA@SiO2 packed column.
SIGNIFICANCE:
The effects of temperature and injection volume on separation of MOC-PA@SiO2 packed column were further investigated. This column also exhibited excellent repeatability, stability and column-to-column reproducibility on separation in HPLC. This work indicates that chiral MOCs are a promising class of chiral materials to prepare new CSPs for HPLC enantioseparation.
2025-01-23Journal of Physical Chemistry Letters
Improved Description of Environment and Vibronic Effects with Electrostatically Embedded ML Potentials
Article
作者: Zinovjev, Kirill ; Curutchet, Carles
Incorporation of environment and vibronic effects in simulations of optical spectra and excited state dynamics is commonly done by combining molecular dynamics with excited state calculations, which allows to estimate the spectral density describing the frequency-dependent system-bath coupling strength. The need for efficient sampling, however, usually leads to the adoption of classical force fields despite well-known inaccuracies due to the mismatch with the excited state method. Here, we present a multiscale strategy that overcomes this limitation by combining EMLE simulations based on electrostatically embedded ML potentials with the QM/MMPol polarizable embedding model to compute the excited states and spectral density of 3-methyl-indole, the chromophoric moiety of tryptophan that mediates a variety of important biological functions, in the gas phase, in water solution, and in the human serum albumin protein. Our protocol provides highly accurate results that faithfully reproduce their ab initio QM/MM counterparts, thus paving the way for accurate investigations on the interrelation between the time scales of biological motion and the photophysics of tryptophan and other biosystems.
100 项与 艾司氟比洛芬 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 骨关节炎 | 日本 | 2015-09-28 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 踝损伤 | 临床3期 | 德国 | 2025-03-31 | |
| 挫伤 | 临床3期 | 德国 | 2025-02-20 | |
| 疼痛 | 临床3期 | 德国 | 2025-02-20 | |
| 膝关节炎 | 临床3期 | 印尼 | 2018-02-05 | |
| 运动损伤 | 临床2期 | 德国 | 2021-05-20 | |
| 软组织损伤 | 临床2期 | 德国 | 2021-05-20 | |
| 扭伤和拉伤 | 临床2期 | 德国 | 2021-05-20 | |
| 急性疼痛 | 临床2期 | 美国 | 2016-07-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 200 | (Active Arm) | 範艱遞簾夢簾襯選襯積(艱餘鹽繭範積鹽簾願構) = 壓製糧觸衊糧鬱蓋廠網 鑰鑰壓築蓋壓壓衊鹽願 (選窪廠網膚構觸醖醖衊, 11.1) 更多 | - | 2023-09-28 | ||
(Control Drug) | 範艱遞簾夢簾襯選襯積(艱餘鹽繭範積鹽簾願構) = 繭簾繭願簾願範衊鹹蓋 鑰鑰壓築蓋壓壓衊鹽願 (選窪廠網膚構觸醖醖衊, 11.9) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用