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更新于：2025-02-15
Esflurbiprofen
艾司氟比洛芬
更新于：2025-02-15
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2015-09-28), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C15H13FO2 |
InChIKeySYTBZMRGLBWNTM-JTQLQIEISA-N |
CAS号51543-39-6 |
关联
18
项与 艾司氟比洛芬 相关的临床试验NCT06823284
Characterization of Relative Bioavailability of a Newly Developed Esflurbiprofen Topical System (EFTS) in Comparison with a Marketed Oral Flurbiprofen-containing Tablet Formulation After Multiple-dose Administration Including EFTS Adhesion Assessment - a Phase I, Open-label, Randomized, 2-period, Cross-over Study in Healthy Subjects
TCTR20241110007
Efficacy of S-flurbiprofen Plaster in Moderate to Severe Knee Osteoarthritis: A Randomized Controlled Trial
TCTR20240929002
Efficacy of Esflurbiprofen transdermal patch for postoperative analgesia in multilevel posterior lumbar spinal fusion: A randomized controlled trial
100 项与 艾司氟比洛芬 相关的临床结果
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100 项与 艾司氟比洛芬 相关的转化医学
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100 项与 艾司氟比洛芬 相关的专利（医药）
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557
项与 艾司氟比洛芬 相关的文献（医药）2024-12-01SCIENCE OF THE TOTAL ENVIRONMENT
Evaluating a vertical greening system mesocosm for kitchen greywater treatment: Comparison among vegetation species in water consumption, biomass growth and pollutants uptake and removal
Article
作者: Celadon, Nicola ; Borin, Maurizio ; Ferro, Nicola Dal ; Dal Ferro, Nicola
The escalating climate imbalance, coupled with rising water demands in rapidly expanding urban areas, is forcing scientists and policymakers to seek alternative strategies for efficient water resource management. Nature Based Solutions (NBS) are gaining prominence due to their ability to provide multiple ecosystem services. However, the quantification of benefits and drawbacks mediated by different vegetation species remains inadequate. In this study, we investigated the performance of a pot-based vertical greening system (VGS) designed to integrate the functions of green facades with those of treatment wetlands. The VGS was vegetated with Mentha aquatica L. (hereafter Mentha), Oenanthe javanica (Blume) DC. (hereafter Oenanthe) and Lysimachia nummularia L. (hereafter Lysimachia), and their respective effects on water balance and mass removal of common greywater pollutants were compared. Results indicated that VGS lines vegetated with Oenanthe and Mentha exhibited comparable pollutant removals. Oenanthe showed a preference for greywater that had already undergone partial treatment, while Mentha was not affected by any pollutant load in water removal -48.1 % of total inflow- and in nutrients uptake in aboveground biomass -14.3 % N and 7 % P- due to sustained and robust growth, outperforming Oenanthe and Lysimachia. This has suggested the potential use of Oenathe in combination with Mentha for enhanced performances, particularly given Oenanthe's rapid growth in the early season and high biomass and nitrogen content following initial greywater treatment.
2024-11-01JOURNAL OF MOLECULAR STRUCTURE
Synthesis of novel (S)-flurbiprofen-based esters for cancer treatment by targeting thymidine phosphorylase via Biomolecular Approaches
作者: Ahmad, Manzoor ; Ali, Mumtaz ; Al-Harrasi, Ahmed ; Zainab ; Ayaz, Muhammad ; Khan, Majid ; Halim, Sobia Ahsan ; Khan, Ajmal ; Alam, Aftab ; Latif, Abdul ; Rehman, Najeeb Ur
The current work is based on the synthesis of novel ester derivatives (1-17) of com. available drug flurbiprofen by using two methods.In the first method, CDI (1,1-carbonyldiimidazole) as a coupling reagent was used to stimulate the acid of flurbiprofen then various substituted phenols were added to the reaction mixture in the presence triethylamine in acetonitrile solvent.While in the second method, different alkyl halides were directly treated with the acid of flurbiprofen in the occurrence of potassium carbonate as a base in DMF solvent.The reactions direction was checked through thin layer chromatog.Modern spectroscopic techniques like, HR-ESI-MS, 1H- and 13C NMR were used for structural elucidation and finally these compounds were subjected for their thymidine phosphorylase inhibitory potential.Eight compounds (1, 5, 7, 2, 12, 6, 17, and 8) amongst the series were found potent inhibitors having IC50 values of 2.3 ± 0.6 to 14.9 ± 0.3 μM better than standard 7-deazxanthine = 15.1 ± 0.1 μM.Similarly, eight compounds showed significant to less activity while compound 15 was found inactive.The docking anal. reflects excellent binding of the active mols. at the predicted allosteric site of TP and the docking results correlates well with the exptl. findings.
2024-08-13Cureus Journal of Medical Science
Efficacy of S-Flurbiprofen Plaster for Analgesia Following Total Hip Arthroplasty
Article
作者: Mitani, Shigeru ; Namba, Yoshifumi ; Kawamoto, Toyohiro ; Miyake, Yoshiaki ; Furuichi, Shuro ; Umehara, Norifumi
PURPOSE:
S-flurbiprofen (SFP) plaster, a non-steroidal anti-inflammatory drug preparation that penetrates effectively into deep tissue, is currently used as a conservative treatment for osteoarthritis. We investigated the analgesic and adverse effects of SFP plaster after total hip arthroplasty (THA).
METHODS:
A retrospective comparative study identified 100 patients who underwent primary THA in our department. Group A consisted of 50 patients who received the selective cyclooxygenase-2 inhibitor celecoxib for 14 days after surgery, while Group B consisted of 50 patients who received SFP plaster for 14 days after surgery. We noted the numerical rating pain intensity scale (NRS) score, body temperature, and adverse effects of the analgesics.
RESULTS:
Groups A and B showed no significant difference in NRS scores (p > 0.05). The body temperature was significantly higher in Group B than in Group A on days one, two, three, and five (p < 0.01). In Group A, two patients (4%) showed drug-induced renal dysfunction, and one patient (2%) showed gastrointestinal disturbance. Patients in Group B showed no systemic or local adverse effects.
CONCLUSIONS:
The application of SFP plaster after THA provided an analgesic effect similar to that obtained with oral celecoxib without causing obvious side effects. Applying an SFP plaster may be an effective solution for postoperative analgesia.
100 项与 艾司氟比洛芬 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 骨关节炎 | 日本 | 2015-09-28 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 膝关节炎 | 临床3期 | 印尼 | 2018-02-05 | |
| 运动损伤 | 临床2期 | 德国 | 2021-05-20 | |
| 挫伤 | 临床2期 | 德国 | 2021-05-20 | |
| 软组织损伤 | 临床2期 | 德国 | 2021-05-20 | |
| 扭伤和拉伤 | 临床2期 | 德国 | 2021-05-20 | |
| 急性疼痛 | 临床2期 | 美国 | 2016-07-01 | |
| 踝损伤 | 临床2期 | 美国 | 2016-07-01 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 200 | (Active Arm) | 獵鬱鏇鹽繭鹽鹹淵築願(襯鏇鹹鑰壓壓蓋願壓顧) = 積製製網淵遞繭範構鏇 齋築簾淵繭鬱糧鏇膚蓋 (壓願範構範餘積鬱製艱, 製觸膚鏇蓋蓋窪襯鹹繭 ~ 鏇築築構夢觸構獵鹽鏇) 更多 | - | 2023-09-28 | ||
(Control Drug) | 獵鬱鏇鹽繭鹽鹹淵築願(襯鏇鹹鑰壓壓蓋願壓顧) = 淵積廠鏇鹽膚觸蓋範顧 齋築簾淵繭鬱糧鏇膚蓋 (壓願範構範餘積鬱製艱, 積簾顧網夢鬱範鹽醖鏇 ~ 餘網鹹糧製鏇構鏇觸簾) 更多 |
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