更新于：2024-12-14
Estazolam
艾司唑仑
更新于：2024-12-14
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 日本 (1975-04-25), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C16H11ClN4 |
InChIKeyCDCHDCWJMGXXRH-UHFFFAOYSA-N |
CAS号29975-16-4 |
关联
13
项与 艾司唑仑 相关的临床试验中国健康受试者空腹及餐后状态下单次口服艾司唑仑片的单中心、开放、随机、两制剂、两序列、两周期、双交叉人体生物等效性试验
艾司唑仑片在健康受试者中的随机、开放、两制剂、单次给药、两周期、交叉空腹和高脂餐后状态下的生物等效性试验
A Clinical and Comparative Study with Randomly Selected Samples of the Effect of Abdominal Acupunctre Combined with Estazolam-Withdrawal Therapy on Estazolam Dependent Insomnia with Mild Anxiety and Depression
100 项与 艾司唑仑 相关的临床结果
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100 项与 艾司唑仑 相关的转化医学
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100 项与 艾司唑仑 相关的专利（医药）
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302
项与 艾司唑仑 相关的文献（医药）2024-11-15JOURNAL OF ANALYTICAL TOXICOLOGY
Deaths involving novel benzodiazepines in Victoria, Australia from 2018 to 2022
Article
作者: Crump, Kerryn ; Glowacki, Linda ; Castle, Jared W ; Joubert, Samantha ; Drummer, Olaf H ; Gerostamoulos, Dimitri ; Di Rago, Matthew
Abstract:
Novel benzodiazepine (NBz) detections in Victorian coronial cases started early in 2018 and have continued to increase in number and type up to December 2022. The 11 different NBz detections included etizolam (n = 82), flualprazolam (n = 43), clonazolam or 8-aminoclonazolam (n = 30), bromazolam (n = 15), clobromazolam (n = 13), phenazepam (n = 13), flubromazolam (n = 12), flubromazepam (n = 8), desalkylflurazepam (n = 6), diclazepam (n = 2), and estazolam (n = 1). The pattern of detections varied over the 5-year period, with different compounds appearing over different time frames. The most recent NBz to appear were bromazolam, clobromazolam, flubromazepam, and phenazepam, whereas etizolam had been seen regularly in case work since 2018. Of the total 133 deaths, 95 were considered drug-related deaths by forensic pathologists with at least one additional CNS depressant also present capable of contributing to death. All deaths involved other (non-benzodiazepine) CNS active drugs, although many involved multiple NBz, with five or more different benzodiazepines detected in eight cases.
2024-07-12Zhongguo zhen jiu = Chinese acupuncture & moxibustion
[Clinical effect of the warm acupuncture of Mongolian medicine on insomnia in the elderly and its brain-gut peptide mechanism: a randomized controlled trial].
Article
作者: A, Gula ; Shen, Meihong ; Lv, Hongyan ; Cao, Li ; Yu, Hong
OBJECTIVE:
To observe the clinical effect and safety of the warm acupuncture of Mongolian medicine in treatment of insomnia in the elderly, and to explore its underlying brain-gut peptide mechanism.
METHODS:
Sixty elderly patients with insomnia were randomly divided into a warm acupuncture group and a western medication group, 30 cases in each group. In the warm acupuncture group, the warm acupuncture of Mongolian medicine was operated at Dinghuixue (at the center of the vertex, the crossing site of the anterior midline and the line connected the upper edges of two ear apexes), Heyixue (at the depression of the spinous process of the 7th cervical vertebra) or Xinxue (at the depression of the spinous process of the 6th thoracic vertebra) in each treatment. Only one of the above points was selected and stimulated for 20 min one treatment and the three points were used alternatively. The treatment was given once every day or every other day, 3 times a week, and for a total of 3 weeks. In the western medication group, estazolam tablets were administered orally, once a day, 1 mg before bedtime, consecutively for 3 weeks. Before and after treatment, as well as in 1-month follow-up visit after the treatment completion, the scores of the Pittsburgh sleep quality index (PSQI) and the insomnia severity index (ISI) were observed in the two groups. The serum brain-related peptide markers (substance P [SP], neuropeptide Y [NPY], 5-hydroxytryptamine 1A [5-HT1A] and 5-hydroxytryptamine 2A [5-HT2A]) were measured before and after treatment, and the clinical efficacy and safety was evaluated in the two groups.
RESULTS:
After treatment and in follow-up, the scores of sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbance and daytime dysfunction, as well as the total scores of PSQI, and ISI scores were all reduced in the two groups (P<0.05, P<0.01); and the scores in the warm acupuncture group were lower than those of the western medication group (P<0.05, P<0.01). After treatment, the levels of serum SP and 5-HT2A were decreased (P<0.01) and the levels of serum NPY and 5-HT1A were increased (P<0.01) when compared with those before treatment in the two groups. The levels of serum SP and 5-HT2A in the warm acupuncture group were lower than those of the western medication group (P<0.05), and the levels of serum NPY and 5-HT1A were higher than those of the western medication group (P<0.05). After treatment, the total effective rate was 93.3% (28/30) in the warm acupuncture group, which was higher than 83.3% (25/30) of the western medication group (P<0.05). No serious adverse reactions were found in the two groups.
CONCLUSION:
Warm acupuncture of Mongolian medicine can effectively improve the sleep quality of the elderly patients with insomnia, and its mechanism may be related to the regulation of the levels of serum SP, NPY, 5-HT1A and 5-HT2A.
2024-02-16Medicine
Insomnia among coronavirus disease 2019 survivors: A single-center cross-sectional study
Article
作者: Lu, Man-Lu ; Yu, Yan ; Wu, Jing-Lin ; Pan, Lei ; Zhu, Ji-Wei ; Liu, Lu ; Kong, Gui-Qing ; Ding, Chang-Ling ; Lv, Liang-Yan
Since the coronavirus disease 2019 (COVID-19) epidemic, insomnia has become one of the longer COVID-19 symptoms. This study aimed to investigate insomnia among COVID-19 survivors and explore the occurrence and influencing factors of insomnia. A cross-sectional study was performed from December 2022 to February 2023 through an online questionnaire star survey with 8 questions. The insomnia severity index scale (ISI) was used to assess the severity of insomnia. Univariate analysis was used to analyze the factors related to COVID-19 infection. A total of 564 participants (183 males and 381 females) were surveyed in the present study. The prevalence of insomnia was 63.12%. Among these insomnia patients, there were 202 (35.82%) with sub-threshold symptoms, 116 (20.57%) with moderate symptoms, and 38 (6.74%) with severe symptoms. Univariate analysis indicated that there were statistically significant differences in the prevalence of insomnia among COVID-19 survivors of different ages, occupations, and educational levels (P < .05). Of the 356 insomnia patients, 185 (51.97%) did not take any measures against insomnia, while those who took drugs only, physical exercise only, drugs and physical exercise, and other measures were 90 (25.28%), 42 (11.80%), 17 (4.78%), and 22 (6.18%), respectively. Additionally, of the 107 insomnia patients with drug therapy, 17 (15.89%) took estazolam, 16 (14.95%) took alprazolam, 39 (36.45%) took zopiclone, and 35 (32.71%) took other drugs to improve insomnia symptoms. The prevalence of insomnia symptoms remains high among COVID-19 survivors in China. Education level and occupation may be the influencing factors. Unfortunately, most patients with insomnia do not take corresponding treatment measures.
100 项与 艾司唑仑 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 焦虑症 | 中国 | 1981-01-01 | |
| 癫痫 | 中国 | 1981-01-01 | |
| 入睡和睡眠障碍 | 日本 | 1975-04-25 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 36 | Sleep medication (+) | 齋憲糧製觸繭築鏇廠艱(襯築鹹構遞膚齋蓋壓顧) = 願蓋獵構簾觸獵膚製鏇 襯鬱鬱膚選鑰糧鏇網簾 (廠繭艱構築網觸構範構, 8.7) 更多 | 不佳 | 2017-10-07 | ||
Sleep medication (-) | 齋憲糧製觸繭築鏇廠艱(襯築鹹構遞膚齋蓋壓顧) = 鏇壓鬱襯鬱鏇蓋衊艱衊 襯鬱鬱膚選鑰糧鏇網簾 (廠繭艱構築網觸構範構, 8.4) 更多 | ||||||
临床4期 | 30 | benzodiazepine | 膚齋構鏇廠願淵齋範壓(簾積觸鑰網鬱遞鏇選願) = 願選鹽顧壓夢顧願餘醖 鹹鬱膚壓壓醖獵齋餘醖 (繭願獵夢膚衊遞構鹹築, 構願鏇積繭醖網憲鑰獵 ~ 願鏇蓋鑰夢製鏇築廠膚) 更多 | - | 2012-03-26 |
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