Allicin

New clinical study indicates ABG10+® supports drug therapy to maintain blood pressure levels in a normal range. MADRID, Oct. 9, 2023 /PRNewswire/ -- Results of a new clinical study have confirmed the blood pressure balancing effect of Pharmactive Biotech Products, SLU's ABG10+®. Aged Black Garlic (ABG10+®) has demonstrated the positive effect in blood pressure in patients exhibiting Grade-1 hypertension receiving prescribed drug treatment. Continue Reading Pharmactive’s Aged Black Garlic Extract May Improve High blood Pressure Levels in New Study Aged Black Garlic is a whole raw garlic bulb (Allium sativum L) that has been aged under controlled temperatures for a certain period of time. Pharmactive's proprietary ageing process potentiates the accumulation of garlic's bioactive complex of antioxidant compounds, including polyphenols, flavonoids, and melanoidins—particularly S-allyl cysteine (SAC). The study, published in the research journal Nutrients, was a randomized, triple-blind controlled trial conducted at the Hospital Universitari Arnau de Vilanova (Lleida, Spain), and in collaboration with the Atherothrombotic Disease Detection and Treatment Unit (UDETMA). Led by Dr. José Carlos Serrano, Ph.D., the study involved 81 volunteers suffering from Stage 1 hypertension and who were already on blood pressure-reducing medication. Over a period of 12 weeks, the subjects received 250mg of ABG10+ daily, which provided 0.25mg of SAC, or a placebo. No changes were made to diet or lifestyle and the subjects were instructed to continue taking their blood pressure medication. Blood pressure measurements were recorded daily at home by the participants as well as at baseline and at the end of the study by specialists. The addition of ABG+ supplementation helped better control blood pressure levels, with reductions observed in both systolic and diastolic blood pressure of 1.8 mmHg and 1.5 mmHg, respectively. Moreover, it was observed via blood serum tests that ABG10+ supplementation may boost the release of nitric oxide and increase the body's antioxidant capacity. ACE (angiotensin converting enzyme) activity seemed to be reduced, and lower blood uric acid levels also were observed. "These secondary parameters help us gain an understanding of the likely mechanism behind ABG10+'s effect on blood pressure," explains Alberto Espinel, Open Innovation Director of Pharmactive. "Nitric oxide is a natural vasorelaxant produced in the body to maintain cardiovascular function, improving blood pressure, and increasing blood flow. Nitric oxide also is a cellular antioxidant and thus helps mitigate oxidative stress and its associated negative effects on blood vessels and the cardiovascular system. Reducing the angiotensin converting enzyme activity is a key strategy to decrease blood pressure in hypertensive patients." The majority of the volunteers enrolled in the study had a medical history of high blood pressure spanning 15 years on average. Despite adhering to their prescribed pharmacological routine, they were still unable to maintain blood pressure levels within a normal range. "This study suggests that incorporating food bioactives such as aged black garlic extract into the treatment regimen could serve as a valuable complement to conventional drug therapy, and could contribute to reduced cardiovascular risk," Espinel adds. "Such intervention could be especially beneficial for the management of arterial high blood pressure in persons experiencing resistance to drug therapy—all without inducing side effects." Hypertension is a leading risk factor for cardiovascular disease, including stroke and heart failure. Research has demonstrated that even modest reductions in blood pressure can lead to meaningful gains in the prevention of such incidents. For example, a reduction of 2mm Hg in systolic blood pressure can reduce the risk of stroke by 10% in middle age. The new study followed favorable outcomes of a 2022 clinical trial involving ABG+, where participants with moderately elevated cholesterol levels achieved significant reduction in diastolic blood pressure (5.85 mmHg on average) compared to placebo. "As garlic ages, its fresh compounds like allicin and sulphur undergo chemical changes, forming new compounds, including SAC and melanoidins," explains Carlos Rodríguez, Communication Manager. "These compounds create the special flavor, aroma, and color of aged black garlic which is why it is a culinary favorite of chefs. Yet these same bioactive compounds are believed to possess powerful antioxidant and support cardio health." Pharmactive's ABG10+ extract is derived from garlic grown and cultivated in Castilla la Mancha, two hours away from the company's facility in Madrid, and gently processed using green technology, without the use of solvents, or chemicals. The ingredient can readily be incorporated into supplements as well as functional foods. About Pharmactive Pharmactive Biotech Products, SLU, is a Madrid-based pioneering biotechnology company that develops and manufactures differentiated natural ingredients supported by science, such as damiana extract, pure saffron extract, and aged black garlic. The company's mission is to make a daily positive and significant impact on people's health and well-being through premium botanical ingredients backed by scientific studies and approved by ethics committees. Be sure to visit Pharmactive at Supply Side West, 25-26 Oct (Booth #2965). For more information, contact: Photo - SOURCE Pharmactive Biotech Products, S.L.

Chongqing, China, July 05, 2023 (GLOBE NEWSWIRE) -- Chongqing Joywin Natural Products Co., Ltd. (hereinafter referred to as Chongqing Joywin) is a company that focuses on extracting various natural ingredients from plants, using the power of plants to serve various industries and comprehensively improve human’s health. It is the chairman unit of China Plant Extracts Association. The company plans to go public in the US by merging with a special purpose acquisition company (hereinafter referred to as "SPAC"). The company is expected to be listed on Nasdaq in the first quarter of 2024, with a valuation of US$300 million (approximately RMB 2 billion). Chongqing Joywin was established in 2010. After 12 years of development, the company has established unique advantages and technical barriers in the field of pharmaceutical raw materials and food supplying to businesses. In the field of pharmaceutical raw materials: Bromelain developed by Chongqing Joywin belongs to the raw material of anti-inflammatory drugs for chronic inflammation and cold medicine, and has unique effects in immune regulation, anti-inflammation, anti-coagulation, and protection of heart health. A number of research institutions have shown that bromelain has an obvious auxiliary effect on alleviating the health hazards of the new coronavirus to human beings. As one of the four manufacturers in the world, Chongqing Joywin's vision is to become the world's largest manufacturer with a market share of more than 30%. In food sector: Chongqing Joywin’s inulin extracted from Jerusalem artichoke has four functions of supplementing dietary fiber, natural prebiotics, sugar substitutes, and fat substitutes. It is the basic raw material for the health industry; the current global demand is 500,000 tons, and It is growing rapidly with a compound annual growth rate of more than 14%. Chongqing Joywin has become one of the world's top five well-known manufacturers in this field, and is currently the world's largest producer of organic inulin. Chongqing Joywin's unique technology and quality certification system (ISO9001/ISO14001/ISO22000/BRC/FSSC22000/KOSHER/HA LAL/cGMP) has enabled Chongqing Joywin to pass the on-site audit and cooperation of many international giant companies. In the field of agriculture: Chongqing Joywin is committed to the development of non-toxic botanical pesticides such as lentinan, star anise oil, resveratrol, allicin, carvacrol, and D-limonene (listed as GRAS substances by the US FDA), which are highly Quality agricultural products and organic products are escorted. While the growth of chemical pesticides is restricted globally, the global biopesticides and preparations market is growing against the trend, and the scale is expected to reach 10 billion US dollars. Chongqing Joywin has an experienced technical team, obtained 24 patents, and has another 11 patents under review. The founder of Chongqing Joywin said that plants are an indispensable renewable resource for the sustainable development of human society. The technological leadership in the field of plant extraction, multi-angle efforts to develop the health industry and high-quality agriculture; and become a leading enterprise in the industry. It is reported that Chongqing Joywin's current core products maintain rapid growth, and it is expected that the performance in the second quarter will increase by more than 150% compared with the first quarter. Contact information: David. sales@joywinworld.com Attachments Chongqing Joywin Natural Products Co., Ltd. Chongqing Joywin Natural Products Co., Ltd. Chongqing Joywin Natural Products Co., Ltd. Chongqing Joywin Natural Products Co., Ltd.