更新于：2024-06-20
Naphazoline Hydrochloride/Pheniramine Maleate
盐酸萘甲唑啉/马来酸非尼拉敏
更新于：2024-06-20
概要
基本信息
药物类型 小分子化药 |
别名 Naphazoline Hydrochloride and Pheniramine Maleate、Pheniramine Maleate Naphazoline Hydrochloride、萘非 + [6] |
作用机制 H1 receptor拮抗剂(组胺H1受体拮抗剂)、α-adrenergic receptor激动剂(α-肾上腺素能受体家族激动剂) |
非在研适应症- |
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C14H15ClN2 |
InChIKeyDJDFFEBSKJCGHC-UHFFFAOYSA-N |
CAS号550-99-2 |
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关联
3
项与 盐酸萘甲唑啉/马来酸非尼拉敏 相关的临床试验A Randomized, Double-blind, Prospective, Multicentric, Superior Efficacy and Safety of Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal Due to Colds or Other Upper Respiratory Allergies
Comparison of Tolerability Between Two Allergy Drops
Tear Osmolarity Over Time With Artificial Tears
100 项与 盐酸萘甲唑啉/马来酸非尼拉敏 相关的临床结果
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100 项与 盐酸萘甲唑啉/马来酸非尼拉敏 相关的转化医学
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100 项与 盐酸萘甲唑啉/马来酸非尼拉敏 相关的专利（医药）
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26
项与 盐酸萘甲唑啉/马来酸非尼拉敏 相关的文献（医药）2023-07-04Clinical & experimental optometry
Understanding ocular comfort differences between 0.7% olopatadine and 0.3% pheniramine maleate/0.025% naphazoline hydrochloride eye drops
Article
作者: Christensen, Mike ; Logan, Amy ; McGwin, Gerald ; Brafford, Randy ; Kelley, Laurel R ; Franklin, Quentin ; Hogan, Catherine ; Pucker, Andrew D. ; Lievens, Chris
CLINICAL RELEVANCE:
This study found 0.7% olopatadine (Pataday Once Daily Relief Extra Strength) eye drops to provide better initial comfort than 0.3% pheniramine maleate/0.025% naphazoline hydrochloride (VISINE® Allergy Eye Relief Multi-Action Antihistamine and Redness Reliever) eye drops suggesting that patients may comply better with the Pataday than VISINE.
BACKGROUND:
To compare the ocular comfort at instillation of Pataday and VISINE allergy eye drops.
METHODS:
Minimally symptomatic participants were recruited based upon Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire scores (≤3 units); they also had minimal between-eye inter-ocular comfort differences as judged by visual analogue scale scores (VAS; ≤7 units). Baseline comfort was evaluated by eye with a VAS. One drop of Pataday or VISINE was then applied to the right eye with the alternative drop being applied to the left eye. The same VAS evaluated comfort by eye at drop instillation, and then at 30 seconds, 1 minute, and 2 minutes post-instillation. Drop experience was also evaluated with Likert questions. LogMAR visual acuities and bulbar conjunctival redness were evaluated pre- and post-drop instillation.
RESULTS:
A total of 159 participants were recruited (mean ± SD age = 26.2 ± 7.5). The VAS found that eyes treated with Pataday were significantly more comfortable at instillation than eyes treated with VISINE. Likert questions indicated that participants significantly preferred Pataday drops compared to the VISINE drops at instillation with regards to overall eye comfort, eye stinging, eye burning, and foreign body sensation. There were no between drop differences in visual acuity, though eyes treated with VISINE were less red than eyes treated with Pataday.
CONCLUSIONS:
Topically applied Pataday drops were more comfortable than VISINE drops.
2022-12-01BMC chemistry3区 · 化学
A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities
3区 · 化学
ArticleOA
作者: Hassan, Amal M ; Kelani, Khadiga M ; Hegazy, Maha A ; Tantawy, Mahmoud A
Abstract:
Impurity profiling of a pharmaceutical compound is now taking great attention during quality assessment of pharmaceuticals, as presence of small amount of impurities may affect safety and efficacy. In this work, a novel TLC chromatographic method coupled with densitometric detection was established for the simultaneous quantification of naphazoline HCl, pheniramine maleate and three of their official impurities, namely; naphazoline impurity B, pheniramine impurities; A & B. Chromatographic separation was carried out on TLC aluminum silica plates F254, as a stationary phase, using methanol: ethyl acetate: 33.0% ammonia (2.0: 8.0: 1.0, by volume), as a mobile phase. Plates were examined at 260.0 nm and International Council for Harmonisation (ICH) guidelines were followed for method’s validation. Important factors, such as; composition of mobile phase and detection wavelengths were optimized. Linearity was achieved over the ranges of 2.0–50.0 µg band−1for naphazoline, 10.0–110.0 µg band−1for pheniramine, 0.1–10.0 µg band−1for naphazoline impurity B and 2.0–50.0 µg band−1for both pheniramine impurities. The proposed method was assessed in terms of accuracy, precision and robustness where satisfactory results (recovery % ≈ 100% and RSD < 2) were obtained. The method was also applied for the simultaneous determination of naphazoline HCl and pheniramine maleate, in Naphcon-A®eye drops, with respective recoveries of 101.36% and 100.94%. Method greenness was evaluated and compared to the reported HPLC one via environmental, health and safety tool. The developed method has much potential over the reported one of being simple, selective, economic and time saving for the analysis of the five cited compounds.
2021-01-01Medicine, science, and the law4区 · 医学
Urine drug-testing tampering approaches: Turkish probationers
4区 · 医学
Article
作者: Akgür, Serap Annette ; Aydoğdu, Melike
The growing numbers of individual and social problems associated with drug abuse necessitate new approaches in drug-testing systems. Equally, drug abusers may attempt to invalidate drug testing using different methods such as adulteration, dilution and substitution. This study aims to investigate tampering methods commonly used by Turkish substance-using probationers and evaluate their effects on toxicological drug-testing results. Initially, probationer urinary screening test results and laboratory substitution documents were evaluated to investigate the dilution and substitution attempt. Additionally, an experimental study was carried out by using readily available household products (bleach, vinegar, drain opener, eye drops) for adulteration. The effect of these agents was investigated for 11‐nor‐9‐carboxy-Δ9‐tetrahydrocannabinol (THC–COOH), amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). It was determined that probationers preferred unbranded products (syringes, nylon bottles, etc.) for urine substitution. To detect dilution, screening test results were evaluated along with creatinine values. The variability of mean creatinine values can change the rate of the before-negative and after-positive ratio. For adulteration method, the high amounts of bleach provided false-negative results for THC–COOH and amphetamine, but spiking in any concentration of bleach affected MDMA results, causing a slight increase. Vinegar did not affect the THC–COOH and amphetamine results. However, false-negative results were observed for MDMA, with high amounts of vinegar-spiked urine samples. Drain opener was added in large quantities, and false-negative results were observed for all analytes. Visine eye drops did not have any effect on THC–COOH or amphetamine, but a high quantity of eye drops had a slight decreasing effect for MDMA.
1
项与 盐酸萘甲唑啉/马来酸非尼拉敏 相关的新闻（医药）2024-05-13
·信狐药迅
100 项与 盐酸萘甲唑啉/马来酸非尼拉敏 相关的药物交易
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外链
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 变应性结膜炎 | 美国 | 1994-06-08 | |
| 眼部疾病 | 美国 | 1994-06-08 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | - | 構鹹膚繭繭衊鹹遞襯獵(網鏇積衊遞選鬱蓋選築) = 衊遞糧糧積壓憲齋襯獵 鹹憲夢窪醖廠壓襯窪齋 (觸鏇憲選簾廠遞糧餘繭 ) 更多 | - | 2009-04-01 | ||
Lubricant Eye Drops | 鏇製鬱鑰範糧鬱顧夢觸(鏇廠繭願衊築觸顧網構) = 鏇鹹顧蓋製窪獵鏇襯獵 選壓夢鹽獵憲夢鑰鏇繭 (衊膚齋鹹蓋積淵範衊顧 ) |
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