作者: Ramasawmy, Rajiv ; Khan, Jaffar M. ; Rogers, Toby ; Babaliaros, Vasilis C. ; Herzka, Daniel A. ; Lederman, Robert J. ; Schenke, William H. ; Paone, Gaetano ; Chen, Marcus Y. ; Greenbaum, Adam B.

AbstractObjectivesPledget‐assisted suture tricuspid valve annuloplasty (PASTA) is a novel technique using marketed equipment to deliver percutaneous trans‐annular sutures to create a double‐orifice tricuspid valve.BackgroundTricuspid regurgitation is a malignant disease with high surgical mortality and no commercially available transcatheter solution in the US.MethodsTwo iterations of PASTA were tested using trans‐apical or trans‐jugular access in swine. Catheters directed paired coronary guidewires to septal and lateral targets on the tricuspid annulus under fluoroscopic and echocardiographic guidance. Guidewires were electrified to traverse the annular targets and exchanged for pledgeted sutures. The sutures were drawn together and knotted, apposing septal and lateral targets, creating a double orifice tricuspid valve.ResultsTwenty‐two pigs underwent PASTA. Annular and chamber dimensions were reduced (annular area, 10.1 ± 0.8 cm2 to 3.8 ± 1.5 cm2 (naïve) and 13.1 ± 1.5 cm2 to 6.2 ± 1.0 cm2 (diseased); septal‐lateral diameter, 3.9 ± 0.3 mm to 1.4 ± 0.6 mm (naïve) and 4.4 ± 0.4 mm to 1.7 ± 1.0 mm (diseased); and right ventricular end‐diastolic volume, 94 ± 13 ml to 85 ± 14 ml (naïve) and 157 ± 25 ml to 143 ± 20 ml (diseased)). MRI derived tricuspid regurgitation fraction fell from 32 ± 12% to 4 ± 5%. Results were sustained at 30 days. Pledget pull‐through force was five‐fold higher (40.6 ± 11.7N vs 8.0 ± 2.6N, P < .01) using this strategy compared to single puncture techniques used to anchor current investigational devices. Serious complications were related to apical access.ConclusionsPASTA reduces annular dimensions and tricuspid regurgitation in pigs. It may be cautiously applied to selected patients with severe tricuspid regurgitation and no options. This is the first transcatheter procedure, to our knowledge, to deliver standard pledgeted sutures to repair cardiac pathology.

2017-11-01·Nutrition, Metabolism and Cardiovascular Diseases3区 · 医学

A systematic review on the relations between pasta consumption and cardio-metabolic risk factors

3区 · 医学

Review

作者: Ha, M-A ; Li, J ; Liu, S ; Riccardi, G ; Huang, M

AIMSThe traditional Italian dish pasta is a major food source of starch with low glycemic index (GI) and an important low-GI component of the Mediterranean diet. This systematic review aimed at assessing comprehensively and in-depth the potential benefit of pasta on cardio-metabolic disease risk factors.DATA SYNTHESISFollowing a standard protocol, we conducted a systematic literature search of PubMed, CINAHL, and Cochrane Central Register of Controlled Trials for prospective cohort studies and randomized controlled dietary intervention trials that examined pasta and pasta-related fiber and grain intake in relation to cardio-metabolic risk factors of interest. Studies comparing postprandial glucose response to pasta with that to bread or potato were quantitatively summarized using meta-analysis of standardized mean difference. Evidence from studies with pasta as part of low-GI dietary intervention and studies investigating different types of pasta were qualitatively summarized.CONCLUSIONSPasta meals have significantly lower postprandial glucose response than bread or potato meals, but evidence was lacking in terms of how the intake of pasta can influence cardio-metabolic disease risk. More long-term randomized controlled trials are needed where investigators directly contrast the cardio-metabolic effects of pasta and bread or potato. Long-term prospective cohort studies with required data available should also be analyzed regarding the effect of pasta intake on disease endpoints.

2011-09-01·Diabetes Care1区 · 医学

Novel Soy Germ Pasta Improves Endothelial Function, Blood Pressure, and Oxidative Stress in Patients With Type 2 Diabetes

1区 · 医学

Article

作者: Perriello, Gabriele ; Asciutti, Stefania ; Nardi, Elisabetta ; Giuliano, Vittorio ; Gizzi, Stefania ; Corazzi, Nadia ; Galli, Francesco ; Castellani, Danilo ; Battezzati, Pier Maria ; Di Matteo, Giorgio ; Setchell, Kenneth D.R. ; Clerici, Carlo

OBJECTIVETo compare the effects of a novel soy germ–enriched pasta, containing isoflavone aglycons, with conventional pasta on endothelial function and cardiovascular risk markers in patients with type 2 diabetes (T2D).RESEARCH DESIGN AND METHODSThis randomized controlled double-blind crossover study compared one serving/day of soy germ pasta and conventional pasta for 8 weeks for effects on brachial artery flow-mediated vasodilation, blood pressure, plasma lipids, oxidized LDL cholesterol, 8-iso-PGF2α, total antioxidant capacity (TAC), glutathione (GSH), and homocysteine.RESULTSIsoflavone-enriched pasta significantly improved arterial stiffness (P = 0.005) and reduced systolic (P = 0.026) and diastolic (P = 0.017) blood pressures. Plasma TAC increased (P = 0.0002), oxidized LDL cholesterol decreased (P = 0.009), 8-iso-PGF2α decreased (P = 0.001), GSH levels increased (P = 0.0003), and homocysteine decreased (P = 0.009) consistent with a reduction in oxidative stress. No significant changes were observed with conventional pasta.CONCLUSIONSPasta enriched with biologically active isoflavone aglycons improved endothelial function and had beneficial effects on cardiovascular risk markers in patients with T2D.

100 项与苯佐卡因/盐酸丁卡因/盐酸辛可卡因/高磺胺相关的药物交易

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