更新于：2024-12-14
Cephalothin Sodium
头孢噻吩钠
更新于：2024-12-14
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1974-12-18), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C16H16N2NaO6S2 |
InChIKeyXXDPRVHYESWPEX-XRZFDKQNSA-N |
CAS号58-71-9 |
关联
2
项与 头孢噻吩钠 相关的临床试验A Randomized Clinical Trial on the Efficacy and Cost-efficacy of Adding on a Mindfulness-based Therapy to Standard Medical Prophylaxis in the Treatment of Patients With Chronic Migraine Associated to Medication Overuse Following Structured Withdrawal: the Mind-CM Study
Use of Mosquito Net Mesh in Comparison With Polypropylene Mesh for Ventral Hernia Repair.
100 项与 头孢噻吩钠 相关的临床结果
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100 项与 头孢噻吩钠 相关的转化医学
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100 项与 头孢噻吩钠 相关的专利（医药）
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4,010
项与 头孢噻吩钠 相关的文献（医药）2024-12-31Future Science OA
Formulation and characterization of antibiotic drug loaded aquasome for the topical application
Article
作者: Shanmugam, Bhuvaneshwari ; Srinivasan, Umashankar Marakanam
Aim: This study aimed to develop a topical antibiotic drug delivery system using aquasomes for enhanced treatment of skin and soft tissue infections (SSTIs). Materials & methods: Cephalothin was loaded into aquasomes using a multi-step process and optimized using design of experiment. The aquasomes were characterized for FT-IR, SEM and zeta potential analysis. Entrapment efficacy, In vitro drug release studies, antibacterial assays and stability study was performed to evaluate the efficacy of the formulated aquasomes. Results & conclusion: The formulated cephalothin-loaded aquasomes exhibited stable properties, controlled drug release and significant antibacterial activity against bacteria. This proves that the developed aquasome-based delivery system has the potential for sustained treatment of SSTIs.
2024-12-31VETERINARY QUARTERLY
Antimicrobial susceptibility and resistome of
Actinobacillus pleuropneumoniae
in Taiwan: a next-generation sequencing analysis
Article
作者: Lin, Chao-Nan ; Chiou, Ming-Tang ; Hsueh, Po-Ren ; Hsu, Feng-Yang ; Lai, Pan-Yun ; Ke, Chiao-Hsu
Actinobacillus pleuropneumoniae infection causes a high mortality rate in porcine animals. Antimicrobial resistance poses global threats to public health. The current study aimed to determine the antimicrobial susceptibilities and probe the resistome of A. pleuropneumoniae in Taiwan. Herein, 133 isolates were retrospectively collected; upon initial screening, 38 samples were subjected to next-generation sequencing (NGS). Over the period 2017-2022, the lowest frequencies of resistant isolates were found for ceftiofur, cephalexin, cephalothin, and enrofloxacin, while the highest frequencies of resistant isolates were found for oxytetracycline, streptomycin, doxycycline, ampicillin, amoxicillin, kanamycin, and florfenicol. Furthermore, most isolates (71.4%) showed multiple drug resistance. NGS-based resistome analysis revealed aminoglycoside- and tetracycline-related genes at the highest prevalence, followed by genes related to beta-lactam, sulfamethoxazole, florphenicol, and macrolide. A plasmid replicon (repUS47) and insertion sequences (IS10R and ISVAp11) were identified in resistant isolates. Notably, the multiple resistance roles of the insertion sequence IS10R were widely proposed in human medicine; however, this is the first time IS10R has been reported in veterinary medicine. Concordance analysis revealed a high consistency of phenotypic and genotypic susceptibility to florphenicol, tilmicosin, doxycycline, and oxytetracycline. The current study reports the antimicrobial characterization of A. pleuropneumoniae for the first time in Taiwan using NGS.
2024-10-22ACS Omega
Little-Cost Potentiometric and Spectrophotometric Procedures for Cephalothin Assessment in Pure and Biological Fluids
Article
作者: A. Farghaly, Othman
Low-cost potentiometric and spectrophotometric procedures for cephalothin (CPI) determination in pure and biological fluids were investigated. The potentiometric technique is created through titration of CPI with an aqueous medium of 0.1 M NaOH at an ionic strength of μ = 0.3 M sodium chloride and room temperature by a combined glass pH electrode. Using the standard addition method, we found that the detection and quantitative limits were 0.042 mg/mL, with the standard deviation SD = 0.011, correlation coefficient R = 0.9880 (n = 5), and linear concentration ranges from 0.042 to 0.82 mg/mL. This technique was utilized to assess CPI in pure solutions, urine, and serum with suitable results. No interference was exposed in the presence of public components of the samples under study. Recovery of CPI for pure and biological fluids is in the range of 98.2-101%. Also, the spectrophotometric method has been performed through the formation of the Prussian Blue (PB) complex. The reaction between the acidic hydrolysis product of CPI (T = 60 °C) and the mixture of Fe3+ with hexacyanoferrate (III) ions (HCF(III)) was detected for the spectrophotometric determination of the drug. The maximum absorbance of the formed complex was measured at λ = 283 nm with 2.0 × 103 L mol-1 cm-1 molar absorptivity. Reaction states have been advanced to acquire the PB complex of great sensitivity and longer stability. In optimal states, the absorbent of the PB compound was attained to grow linearly with the increase in the concentration of CPI, which agrees with the correlation coefficient values. The detection and quantitative limits were 0.000036 and 0.0012 mg/mL, respectively, with the standard deviation, SD = 0.0005, correlation coefficient, R = 0.9955 (n = 5), and the linearity range of the calibration plot 0.0005-0.02 mg/mL CPI. The planned technique was positively utilized for the detection of CPI in both urine and serum models. The results fit well with the data found from the potentiometric method.
1
项与 头孢噻吩钠 相关的新闻（医药）2024-09-20
·药闻康策
100 项与 头孢噻吩钠 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 菌血症 | 日本 | 1976-09-01 | |
| 复杂皮肤和皮肤结构感染 | 日本 | 1976-09-01 | |
| 肺脓肿 | 日本 | 1976-09-01 | |
| 骨髓炎 | 日本 | 1976-09-01 | |
| 中耳炎 | 日本 | 1976-09-01 | |
| 腹膜炎 | 日本 | 1976-09-01 | |
| 猩红热 | 日本 | 1976-09-01 | |
| 扁桃体炎 | 日本 | 1976-09-01 | |
| 细菌感染 | 美国 | 1974-12-18 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 19 | 鑰鬱獵廠網簾衊選獵鬱(醖範襯簾衊獵鬱鏇衊窪) = 憲積衊襯觸遞製齋積築 遞膚糧壓製觸糧範鹽觸 (艱糧鬱壓鏇構積夢觸顧 ) 更多 | 积极 | 2014-11-11 | |||
鑰鬱獵廠網簾衊選獵鬱(醖範襯簾衊獵鬱鏇衊窪) = 廠壓鏇夢積鑰範選獵鏇 遞膚糧壓製觸糧範鹽觸 (艱糧鬱壓鏇構積夢觸顧 ) 更多 |
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