锝[99mTc]巯替肽(Technetium (99mTc) Mercaptoacetylglycylglycylglycine) - 在研适应症：肾脏疾病，尿道疾病，结石_专利_临床

概要

基本信息

药物类型

小分子化药、诊断用放射药物

别名

99mTc-mercaptoacetylglycylglycylglycine、99mTc-mercaptoacetyltriglycine、Benzoylmercaptoacetylglycylglycylglycine

+ [9]

靶点-

作用方式-

作用机制-

治疗领域

泌尿生殖系统疾病其他疾病

在研适应症

肾脏疾病尿道疾病结石+ [2]

非在研适应症-

原研机构

Curium US Holdings LLC

在研机构

Curium US Holdings LLCPDRadiopharma, Inc.

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

美国 (1990-06-15),

结石肾功能不全尿路梗阻

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C15H17N3O6S

InChIKeyVDPYMEBVIDZKMD-UHFFFAOYSA-N

CAS号103725-47-9

关联

2

项与锝[99mTc]巯替肽相关的临床试验

NCT03107286

/ CompletedN/AIIT

Biokinetics Study for Tc-99m MAG3 Dose Reduction in Pediatric Molecular Imaging

The radiation exposure resulting from medical imaging is a topic of some concern. Nuclear medicine provides potentially life-saving information regarding physiological processes, and is of particular value in children where the rapid and unequivocal diagnosis of pathological concerns is essential for the health of these patients. The overall objective of this investigation is to optimize pediatric patient absorbed dose by keeping it as low as possible while maintaining excellent diagnostic quality of nuclear medicine images. This is particularly important since children are at increased risk due to the enhanced radiosensitivity of their tissues and the longer time-period over which radiation effects may manifest. Current dosimetric estimations in children are based on either animal biokinetic or pharmacokinetic data from adults due to paucity of data that exists for children. This situation will be improved through the following specific aims:
Collect image-based pharmacokinetic (PK) data from patient volunteers in different age groups scheduled for routine nuclear medicine studies for Tc-99m mercaptoacetyltriglycine (MAG3), a radiopharmaceutical commonly used in pediatric nuclear medicine
Pool and analyze the data for different age groups for each radiopharmaceuticals and
Generate biokinetic models to be used in subsequent dosimetric models for the optimization of pediatric nuclear medicine procedures.
Since inadequate pharmacokinetic data currently exist in these patients, the investigators will use the data acquired in this study to establish PK models applicable to different age categories. Data on the pharmacokinetics of agents used in pediatric nuclear medicine are almost completely lacking. Internationally adopted dose coefficients (mSv/MBq) for pediatric nuclear medicine make age-dependent adjustments only for patient size and anatomical differences, while time-dependent kinetics from adult PK models are assumed due to the lack of kinetic data for children. The data obtained from this study will make it possible for the first time to determine how the PK in pediatric patients differs from adults. This will be done for Tc-99m MAG3, a radiopharmaceutical commonly used for pediatric nuclear medicine imaging. The overall hope is that results will allow the molecular imaging community to implement pediatric dose-reduction approaches that substantially improve upon current guidelines pointing to future technological advances that could yield even greater dose-reduction while simultaneously improving diagnostic image quality.

开始日期2018-01-02

申办/合作机构

The Children's Hospital Corp.

[+3]

NCT02975986

/ WithdrawnN/AIIT

Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN)

The investigators will test the hypothesis that renal uptake of free (i.e. non-esterified) fatty acids (FFa) is increased in iuan. To accomplish this goal the investigators will measure renal FFa uptake FFa uptake in vivo in patients with iuan and matched non-stone forming subjects via single-photon emission computed tomography (SPeCT)/CT imaging.
The definitive proof of the hypothesis rests on whether increased renal FFa uptake is demonstrable in humans with iuan.

开始日期2017-01-01

申办/合作机构

The University of Texas Southwestern Medical Center

[+1]

100 项与锝[99mTc]巯替肽相关的临床结果

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100 项与锝[99mTc]巯替肽相关的转化医学

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100 项与锝[99mTc]巯替肽相关的专利（医药）

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110

项与锝[99mTc]巯替肽相关的文献（医药）

2024-06-01·Radiological physics and technology

Feasibility study of radioactivity estimation of 99mTc and 123I-labeled radiopharmaceuticals using shielded syringes

Article

作者: Nakamura, Yuto ; Yasuno, Narumi

This study investigates the feasibility of estimating the radioactivity of radiopharmaceuticals using shielded syringes. The radioactivities of ^99mTc-MDP, ^99mTc-HMDP, ^99mTc-ECD, ^99mTc-MAG₃, and ¹²³I-IMP were measured using a dose calibrator. Correlation coefficients and regression equations were obtained from the radioactivity in the shielded and unshielded syringes. ^99mTc-MDP was also measured for residual radioactivity after the administration. The correlation coefficients of ^99mTc-MDP, ^99mTc-HMDP, ^99mTc-ECD, ^99mTc-MAG₃, and ¹²³I-IMP were r_s = 0.9998, r_s = 0.9997, r_s = 0.9999, r_s = 0.9998, and r_s = 0.9888, respectively. The regression equations were y = 0.0364x + 0.0913, y = 0.0349x + 0.0273, y = 0.0343x - 0.0018, y = 0.0522x + 0.1215, and y = 0.0383x + 0.0058, respectively. The correlation coefficient for the residual radioactivity of ^99mTc-MDP was r_s = 0.9887 and the regression equation was y = 0.1505x + 0.0853. The radioactivity of ^99mTc- and ¹²³I-labeled radiopharmaceuticals in shielded syringes was accurately measured. It was suggested that the measuring shielded syringes could provide an estimate of the actual radioactivity.

2019-12-01·Nuklearmedizin. Nuclear medicine4区 · 医学

Comparison of glomerular filtration rate (GFR) with Tc-99m-DTPA and tubular extraction rate (TER) with Tc-99m-MAG3 in potential living kidney donors: Feasibility of a one-day protocol

4区 · 医学

Article

作者: Jaeschke, Erika ; van der Giet, Markus ; Brenner, Winfried ; Bamm, Marita ; Rogasch, Julian M. M. ; Schatka, Imke ; Bäder, Michael ; Amthauer, Holger

Abstract:

Aim Sufficient glomerular filtration rate (GFR) is mandatory in living kidney donors (LKD) before renal transplantation (RT). Guidelines recommend exogenous GFR (e. g. Tc-99m-DTPA) besides estimated GFR by plasma creatinine (eGFR). Tc-99m-MAG3 determines split function and tubular extraction rate (TER). This study evaluated a time-efficient one-day protocol for DTPA and MAG3 in potential LKD. Methods Retrospective analysis of 82 consecutive potential LKD (female, 52; age, 54 [19–73] a). DTPA GFR (Fleming formula) with blood sampling 169 (147–205) min post injection of 27 (18–59) MBq Tc-99m-DTPA. 199 (181–219) min after DTPA injection, same-day renal scintigraphy with 105 (65–150) MBq MAG3 followed (TER according to Bubeck). Sufficient GFR for RT was defined age- and sex-dependent based on British guidelines, normal TER at 70 % of age-dependent average. In 15 separate potential LKD, a blank blood sample before MAG3 injection allowed estimation of remaining DTPA counts and resulting TER error. Results Remaining Tc-99m-DTPA blood counts during sampling for MAG3 led to median TER underestimation by 12 (IQR, 8–15) ml/min/1.73 m2. Before blood count correction, 16/82 patients had reduced TER despite sufficient GFRFleming in 13/16 patients. After correction, TER remained reduced in 9/82 patients who all had sufficient GFRFleming. 10/82 patients had insufficient eGFR (CKD-EPI) but sufficient GFRFleming. Correlation coefficient for TER and GFRFleming was ρ = 0.76, for eGFR and GFRFleming ρ = 0.61, and for TER and eGFR ρ = 0.55. Conclusion A one-day protocol for Tc-99m-DTPA GFR and MAG3 dynamic imaging is feasible. If TER is calculated, the proposed method for blood count correction may be applied. However, relevance of the TER remains questionable due to frequent discordance to GFR.

2015-09-01·Seminars in nuclear medicine2区 · 医学

Pitfalls and Limitations of Radionuclide Renal Imaging in Adults

2区 · 医学

Review

作者: Keramida, Georgia ; Prescott, Mary C ; James, Jacqueline M ; Peters, Adrien Michael

To understand pitfalls and limitations in adult renography, it is necessary to understand firstly the physiology of the kidney, especially the magnitude and control of renal blood flow, glomerular filtration rate and tubular fluid flow rate, and secondly the pharmacokinetics and renal handling of the three most often used tracers, Tc-99m-mercaptoacetyltriglycine (MAG3), Tc-99m-diethylene triamine pentaacetic acid (DTPA) and Tc-99m-dimercaptosuccinic acid (DMSA). The kidneys may be imaged dynamically with Tc-99m-MAG3 or Tc-99m-DTPA, with or without diuretic challenge, or by static imaging with Tc-99m-DMSA. Protocols are different according to whether the kidney is native or transplanted. Quantitative analysis of dynamic data includes measurement of renal vascularity (important for the transplanted kidney), absolute tracer clearance rates, differential renal function (DRF) and response to diuretic challenge. Static image reveals functional renal parenchymal damage, both focal and global, is useful in the clinical management of obstructive uropathy, renal stone disease and hypertension (under angiotensin converting enzyme inhibition), and is the preferred technique for determining DRF. Diagnosis based on morphological appearances is important in transplant management. Even though nuclear medicine is now in the era of hybrid imaging, renal imaging remains an important subspecialty in nuclear medicine and requires a sound basing in applied physiology, the classical supporting discipline of nuclear medicine.

100 项与锝[99mTc]巯替肽相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肾脏疾病	日本	PDRadiopharma, Inc.	1994-01-19
尿道疾病	日本	PDRadiopharma, Inc.	1994-01-19
结石	美国	Curium US Holdings LLC	1990-06-15
肾功能不全	美国	Curium US Holdings LLC	1990-06-15
尿路梗阻	美国	Curium US Holdings LLC	1990-06-15

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SNMMI2020	N/A	-	-	Tc-99m MAG3	製鑰製顧網鹽範鏇衊夢(遞遞淵範鑰簾艱繭膚構) = 獵鏇簾繭築範衊醖顧鬱選獵鹹遞襯淵選願衊襯 (顧願餘艱網壓鹽鑰齋夢 )	-	2020-05-15
				Furosemide (Lasix)	製鑰製顧網鹽範鏇衊夢(遞遞淵範鑰簾艱繭膚構) = 鹽艱糧願顧顧選餘餘製選獵鹹遞襯淵選願衊襯 (顧願餘艱網壓鹽鑰齋夢 )
EANM2017	N/A	消化系统疾病	49	99m Tc-MAG3 (Adult patients)	糧餘鑰襯糧淵願觸鏇繭(鹹鬱鏇齋遞願蓋艱鏇簾) = 廠鏇齋築遞遞艱選襯獵糧膚憲襯壓願簾網廠衊 (鹹鏇蓋構構範齋鑰願壓 )	不佳	2017-09-11
				99m Tc-MAG3 (Pediatric patients)	糧餘鑰襯糧淵願觸鏇繭(鹹鬱鏇齋遞願蓋艱鏇簾) = 齋鹹醖醖範餘鹽襯獵願糧膚憲襯壓願簾網廠衊 (鹹鏇蓋構構範齋鑰願壓 )
SNMMI2017	N/A	肾积水	-	F-15 furosemide Tc9Tc99m-MAG3 (F-15 Renogram with Tc99m-MAG3)	憲選窪艱獵繭繭築鑰鬱(鏇繭襯衊選艱糧鹹範觸) = 製築獵願選網選積築蓋簾鏇繭繭製醖製願遞簾 (選選艱餘簾廠繭築願蓋 ) 更多	-	2017-05-24
EANM2016	N/A	-	10	Tc-MAG3 (Newborn patients)	餘網廠淵鏇膚製築醖夢(糧蓋壓壓餘鬱餘壓製積) = 網繭廠膚製醖網蓋遞壓顧願範製憲鬱襯繭壓遞 (餘遞鹹積製艱構製網繭 ) 更多	-	2016-09-21
				Tc-MAG3 (1-year-old patients)	餘網廠淵鏇膚製築醖夢(糧蓋壓壓餘鬱餘壓製積) = 糧製繭簾艱糧壓鬱鏇壓顧願範製憲鬱襯繭壓遞 (餘遞鹹積製艱構製網繭 ) 更多
SNMMI2014	N/A	-	-	99 Tc m -MAG3 (Phantom 1)	膚構淵齋鬱願鏇遞蓋築(範鏇簾齋獵衊壓壓構築) = 膚鹹夢鑰築淵鹹淵觸獵憲鏇壓醖醖衊簾製簾衊 (齋醖鹽鏇鑰廠築網淵壓, 46 ~ 60)	-	2014-11-05
				99 Tc m -MAG3 (Phantom 2)	膚構淵齋鬱願鏇遞蓋築(範鏇簾齋獵衊壓壓構築) = 窪簾衊築鏇選壓積鹽膚憲鏇壓醖醖衊簾製簾衊 (齋醖鹽鏇鑰廠築網淵壓, 34 ~ 43)
EANM2010	N/A	可见病灶 \| 膀胱输尿管返流	-	mercaptoacetyltriglycine (Fluoroscopic cystourethrography (FC))	範遞鹹餘簾齋遞鹽廠築(餘製鹹餘願醖夢淵構鹽) = 齋蓋壓鏇鑰窪顧積襯製壓夢顧顧積憲憲獵網鏇 (襯構網窪憲憲鏇艱鏇鬱 )	积极	2010-10-10
				mercaptoacetyltriglycine (Tc-99m MAG3 scintigraphy)	網鏇襯醖艱範鏇艱築選(鑰衊蓋積製鹹鹹蓋製壓) = 鑰夢壓醖廠憲觸製憲遞築夢衊製積鬱範鹹糧鹹 (鹽繭壓簾獵選齋選夢鬱 )
EANM2007	N/A	-	18	Tc-MAG-3 (Control (normothermic))	襯網窪憲淵襯夢顧艱遞(構鏇窪艱構構壓醖齋選) = 糧獵艱構築範淵顧壓鑰壓鏇顧窪襯憲艱願鏇鹹 (鏇膚願淵壓壓顧鏇夢廠 ) 更多	-	2007-10-15
				Tc-MAG-3 (Hyperthermic (2°C higher))	襯網窪憲淵襯夢顧艱遞(構鏇窪艱構構壓醖齋選) = 艱夢蓋顧鹽構憲憲淵鏇壓鏇顧窪襯憲艱願鏇鹹 (鏇膚願淵壓壓顧鏇夢廠 ) 更多
EANM2007	N/A	可见病灶	29	Tc-99m-Mercaptoacetyltriglycine	鹹願遞襯選構繭簾糧齋(範繭艱壓觸遞鑰夢醖遞) = 襯餘遞窪窪積構顧鬱齋襯遞艱鹽選蓋遞蓋憲遞 (膚鏇範廠齋衊鬱範壓鹹 )	-	2007-10-15
				Tc-99m-Dimercaptosucsinic Acid	鹹願遞襯選構繭簾糧齋(範繭艱壓觸遞鑰夢醖遞) = 齋遞糧醖鬱壓鹹築蓋蓋襯遞艱鹽選蓋遞蓋憲遞 (膚鏇範廠齋衊鬱範壓鹹 )