A Phase 1b, Double-Blind, Randomized, Dose-Escalating, Age De-Escalating, Placebo-Controlled Study to Assess the Safety and Immunogenicity of One or Two Doses of Sing2016 M2SR H3N2 Influenza Vaccine Delivered Intranasally In a Healthy Pediatric Population 6 Months Through 17 Years of Age.

This is a Phase 1b, randomized, double-blind, dose-escalating, age de-escalating, placebo-controlled study of 200 children, ages 6 months to 17 years. This clinical trial is designed to assess the safety, tolerability/reactogenicity, and immunogenicity of one and two doses of Sing2016 M2SR H3N2 influenza vaccine (manufactured by FluGen) administered intranasally in seven cohorts of children. The study design includes pre-planned Safety Review Committee( SRC) reviews.
The first two groups to be vaccinated will be Cohorts 1 and 2. Cohort 1 consists of 45 children 9-17 years old. Thirty of them will receive one dose of the vaccine at a dose of 10^9 TCID50, and 15 will receive one dose of placebo. Cohort 2 comprises 45 children 2-8 years old. Thirty of them will receive one dose of the vaccine at a dose of 10^8 TCID50 and 15 will receive one dose of placebo.
Cohort 3 consists of 25 children 2-8 years old. 15 of them will receive one dose of vaccine at 10^9 TCID50 and 10 will receive one dose of placebo. Once 25 participants in Cohort 3 have completed Day 8 of follow-up, similar to Cohorts 1 and 2, the SRC will review to ensure no halting rules are met and if no rules are met, and the SRC determines it is safe to proceed, simultaneous enrollment into Cohorts 4 and 5 can begin. If any halting rules are met or any concerns are raised by the SRC, an external SMC may meet to discuss the data for recommendations on either progression or clinical trial modification before progression to the next cohort.
Cohort 4 consists of 25 children 2-8 years old; 15 of them will receive two doses of vaccine at 10^9 TCID50 and 10 will receive two doses of placebo, with a 28-day interval between the first and second doses. Due to the limited availability of product, and funding to support additional years of enrollment into Cohorts 5, 6, and 7, the decision was made to stop enrollment after the final participant was enrolled into Cohort 4.
The primary study objective is to assess the safety and tolerability of one and two administrations of the Sing2016 M2SR H3N2 influenza vaccine at 10^8 or 10^9 TCID50 delivered intranasally to healthy participants, 2 to 17 years of age.

开始日期2021-09-10

申办/合作机构

National Institute of Allergy & Infectious Diseases

NCT04785794 / Completed临床1期

Phase 1b Clinical Study to Investigate the Safety and Immunogenicity of the Sing2016 (A/Singapore/INFIMH-16-0019/2016) M2SR H3N2 Monovalent Influenza Vaccine in Adults Ages 50 to 85 Years Old.

This is a randomized, double-blind, placebo-controlled Phase 1b study to evaluate safety and immunogenicity of the investigational Sing2016 M2SR H3N2 influenza vaccine delivered intranasally to a healthy adult population age 50 to 85 years.

开始日期2021-06-30

申办/合作机构

FluGen, Inc.

[+1]

NCT03999554 / Completed临床1期

Phase 1b Clinical Study to Investigate the Safety and Immunogenicity of the Bris10 (A/Brisbane/10/2007) M2SR and Sing2016 (A/Singapore/INFIMH-16-0019/2016) M2SR H3N2 Monovalent Influenza Vaccines

This is a Phase I double-blind, randomized, placebo-controlled study in 250 healthy adults, 18-49 years of age, inclusive, who are in good health and meet all eligibility criteria. The purpose of this dose escalation clinical study is to assess the safety, tolerability/reactogenicity, and immunogenicity of H3N2 M2SR investigational vaccines for prevention of influenza, when delivered at higher dosages or in two doses . Eligible subjects will be screened and randomized to receive two administrations 28 days apart of Sing2016 M2SR at three dose levels (low, medium, high), Bris10 M2SR at one dose level (low), or placebo in a 1:1:1:1:1 ratio. Study duration will be approximately 8 months with subject participation duration approximately 7 months. The primary study objective is to assess the safety and reactogenicity of a monovalent live single replication influenza H3N2 M2SR vaccine.

开始日期2019-09-03

申办/合作机构

FluGen, Inc.

100 项与 H3N2 M2SR influenza vaccine (FluGen) 相关的临床结果

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100 项与 H3N2 M2SR influenza vaccine (FluGen) 相关的转化医学

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100 项与 H3N2 M2SR influenza vaccine (FluGen) 相关的专利（医药）

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项与 H3N2 M2SR influenza vaccine (FluGen) 相关的文献（医药）

2024-12-31·Human Vaccines & Immunotherapeutics

Neutralization potency of the 2023-24 seasonal influenza vaccine against circulating influenza H3N2 strains

Article

作者: Cheng, Ziqi ; Huang, Weijin ; Huang, Xiande ; Liu, Xiaoyu ; Zhao, Chenyan ; Li, Weixuan ; Lv, Yake

Seasonal influenza is a severe disease that significantly impacts public health, causing millions of infections and hundreds of thousands of deaths each year. Seasonal influenza viruses, particularly the H3N2 subtype, exhibit high antigenic variability, often leading to mismatch between vaccine strains and circulating strains. Therefore, rapidly assessing the alignment between existing seasonal influenza vaccine and circulating strains is crucial for enhancing vaccine efficacy. This study, based on a pseudovirus platform, evaluated the match between current influenza H3N2 vaccine strains and circulating strains through cross-neutralization assays using clinical human immune sera against globally circulating influenza virus strains. The research results show that although mutations are present in the circulating strains, the current H3N2 vaccine strain still imparting effective protection, providing a scientific basis for encouraging influenza vaccination. This research methodology can be sustainably applied for the neutralization potency assessment of subsequent circulating strains, establishing a persistent methodological framework.

2024-07-01·The Lancet Infectious Diseases

Safety and immunogenicity of the intranasal H3N2 M2-deficient single-replication influenza vaccine alone or coadministered with an inactivated influenza vaccine (Fluzone High-Dose Quadrivalent) in adults aged 65–85 years in the USA: a multicentre, randomised, double-blind, double-dummy, phase 1b trial

Article

作者: Murray, Bryan ; Neumann, Gabriele ; Fierro, Carlos ; Herber, Renee ; Kawaoka, Yoshihiro ; Moser, Michael J ; Davis, Matthew ; Bilsel, Pamuk ; Aitchison, Roger ; Coelingh, Kathleen ; Rhee, Margaret ; Marshall, David ; White, Alexander ; Eiden, Joseph ; Greenberg, Harry ; Belshe, Robert ; Turner, Mark

BACKGROUNDOlder adults (aged ≥65 years) show increased susceptibility to severe disease with influenza virus infection, accounting for 70-85% of annual influenza-related fatalities in the USA. Stimulating mucosal antibodies and T cells might enhance the low vaccine effectiveness seen in older adults for currently licensed inactivated influenza vaccines, which induce mainly serum antibodies. We aimed to evaluate the safety and immunogenicity of the intranasal H3N2 M2-deficient single-replication (M2SR) vaccine, alone or coadministered with a licensed inactivated influenza vaccine (Fluzone High-Dose Quadrivalent; hereafter referred to as Fluzone HD), in older adults.METHODSIn this multicentre, randomised, double-blind, double-dummy, phase 1b trial, individuals aged 65-85 years who were considered healthy or with stable chronic conditions with no recent (<6 months) influenza vaccinations were recruited from five clinical trial sites in the USA and randomly assigned (3:3:3:1) using a permuted block design to receive the H3N2 M2SR vaccine and Fluzone HD, the H3N2 M2SR vaccine and placebo, Fluzone HD and placebo, or placebo alone. All participants received a single intranasal spray and a single intramuscular injection, whether active or placebo, to maintain masking. The primary outcome was to assess the safety of H3N2 M2SR, administered alone or with Fluzone HD, in the safety analysis set, which included all participants who were randomly assigned and received treatment. Serum and mucosal antibodies were assessed as a secondary endpoint, and cell-mediated immunity as an exploratory endpoint, in participants in the per-protocol population, which included individuals in the safety analysis set without major protocol deviations. This trial is registered with ClinicalTrials.gov, NCT05163847.FINDINGSBetween June 14 and Sept 15, 2022, 305 participants were enrolled and randomly assigned to receive the H3N2 M2SR vaccine plus placebo (n=89), H3N2 M2SR vaccine plus Fluzone HD (n=94), Fluzone HD plus placebo (n=92), or placebo alone (n=30). All randomly assigned participants were included in the safety analysis set. The most frequently reported local symptoms up to day 8 in groups that received M2SR were rhinorrhoea (43% [38 of 89] in the H3N2 M2SR plus placebo group and 38% [36 of 94] in the H3N2 M2SR plus Fluzone HD group), nasal congestion (51% [45 of 89] and 35% [33 of 94]), and injection-site pain (8% [seven of 89] and 49% [46 of 94]), and the most frequently reported solicited systemic symptoms were sore throat (28% [25 of 89]) for M2SR and decreased activity (26% [24 of 94]) for the M2SR plus Fluzone HD group. In the Fluzone HD plus placebo group, the most frequently reported local symptom was injection-site pain (48% [44 of 92]) and systemic symptom was muscle aches (22% [20 of 92]). The frequency of participants with any treatment-emergent adverse event related to vaccination was low across all groups (2-5%). One serious adverse event was reported, in a participant in the Fluzone HD plus placebo group. M2SR with Fluzone HD induced seroconversion (≥four-fold increase in haemagglutination inhibition antibodies from baseline to day 29) in 44 (48%) of 91 participants, compared with 28 (31%) of 90 participants who seroconverted in the Fluzone HD plus placebo group (p=0·023). M2SR with Fluzone HD also induced mucosal and cellular immune responses.INTERPRETATIONThe H3N2 M2SR vaccine coadministered with Fluzone HD in older adults was well tolerated and provided enhanced immunogenicity compared with Fluzone HD administered alone, suggesting potential for improved efficacy of influenza vaccination in this age group. Additional studies are planned to assess efficacy.FUNDINGUS Department of Defense.

2024-04-01·Vaccine

Mucosal immunization with dual influenza/COVID-19 single-replication virus vector protects hamsters from SARS-CoV-2 challenge

Article

作者: Kawaoka, Yoshihiro ; Bielefeldt-Ohmann, Helle ; Marshall, David ; Bowen, Richard ; Hill-Batorski, Lindsay ; Neumann, Gabriele ; Bilsel, Pamuk ; Moser, Michael J ; Matejka, Sarah M

The COVID-19 pandemic has highlighted the need for mucosal vaccines as breakthrough infections, short-lived immune responses and emergence of new variants have challenged the efficacy provided by the first generation of vaccines against SARS-CoV-2 viruses. M2SR SARS-CoV-2, an M2-deleted single-replication influenza virus vector modified to encode the SARS-CoV-2 receptor binding domain, was evaluated following intranasal delivery in a hamster challenge model for protection against Wuhan SARS-CoV-2. An adjuvanted inactivated SARS-CoV-2 whole virus vaccine administered intramuscularly was also evaluated. The intranasal M2SR SARS-CoV-2 was more effective than the intramuscular adjuvanted inactivated whole virus vaccine in providing protection against SARS-CoV-2 challenge. M2SR SARS-CoV-2 elicited neutralizing serum antibodies against Wuhan and Omicron SARS-CoV-2 viruses in addition to cross-reactive mucosal antibodies. Furthermore, M2SR SARS-CoV-2 generated serum HAI and mucosal antibody responses against influenza similar to an H3N2 M2SR influenza vaccine. The intranasal dual influenza/COVID M2SR SARS-CoV-2 vaccine has the potential to provide protection against both influenza and COVID.

项与 H3N2 M2SR influenza vaccine (FluGen) 相关的新闻（医药）

2024-07-12

·BioSpace

FluGen’s Intranasal M2SR Flu Vaccine, Co-Administered with High Dose Vaccine, in Older Adults Shows Superiority Over Flu Shot Alone

– Findings reported today in the journal Lancet Infectious Diseases – Study shows synergistic immunological response generated by M2SR and Fluzone High Dose vaccine when used in combination in the highly vulnerable 65-85 years old population – Results suggest approach could be used for vaccination against future influenza pandemics such as H5N1 MADISON, Wis., July 12, 2024 (GLOBE NEWSWIRE) -- FluGen, Inc., a clinical-stage vaccine company transforming vaccine efficacy in infectious respiratory diseases, today announced the results of its study comparing the coadministration of intranasal M2SR and the high dose flu shot in an unprecedented study of older adults ages 65-85 years. The findings are reported today in the journal Lancet Infectious Diseases ( (24)00351-7/fulltext). The study evaluated the safety, tolerability, and immunological response to FluGen’s investigational supra-seasonal, live, single-replication, intranasal influenza (flu) vaccine when administered with Sanofi’s Fluzone High Dose inactivated influenza vaccine (IIV). There is a demonstrated unmet need for improved flu vaccine options, as current injectable vaccines primarily generate hemagglutinin (HA) antibodies and have shown only modest efficacy in most flu seasons. Funded by the U.S. Department of Defense (DOD), this study evaluated M2SR and Fluzone High Dose alone, and dosed concomitantly, in healthy adults 65-85 years of age, a population considered highly vulnerable to mortality from flu. “Influenza continues to be a major cause of seasonal respiratory epidemics with significant morbidity and mortality, especially in older adults. Current vaccines fall short in three main areas – they don’t last long enough, they don’t protect against viruses that mutate and they don’t block the initial infection in the upper respiratory tract,” said Robert Belshe, MD, founder of Saint Louis University’s Center for Vaccine Development and recipient of the 2023 American College of Physicians James D. Bruce Memorial Award for Distinguished Contributions in Preventive Medicine “The results from this study represent a potential solution that might save millions of older adults from getting sick or worse.” Intranasal vaccines are known to provide a wall of defense at the site of infection to help prevent influenza viruses from entering the nasal mucosa. Intranasal M2SR has shown the ability to elicit mucosal antibodies and also protect against drifted strains while being durable. Standard flu shots on the other hand, generate antibodies in the blood to help fight off the virus after it has already entered the body. Combining the benefits of both nasally delivered vaccines and the standard shot provide the best of both worlds. The study demonstrated M2SR’s ability to statistically significantly raise mucosal antibodies in the nasal passages, serum antibodies against matched and drifted strains of the influenza virus, and cellular immune responses in subjects when compared to Fluzone High Dose and placebo. In a prior Phase 2 drifted H3N2 challenge trial, M2SR demonstrated efficacy against infection and illness across seven years of flu virus drift. Previous studies have also demonstrated that while currently licensed influenza vaccines administered by intramuscular injection generate tremendous antibody responses, only intranasal M2SR stimulates mucosal and cellular immunity as well as serum antibodies. “The idea of delivering two vaccines in one sitting has become widely accepted,” said Paul Radspinner, President and Chief Executive Officer of FluGen. “Imagine being at your local pharmacy for your annual flu shot and also receiving a quick nasal spray that would greatly enhance your chances not only of becoming seriously ill but of being infected at all. This combination solution could have a tremendous impact on the health of older adults." Radspinner went on to discuss the possible impact on influenza pandemic protection. “If H5N1 or any other mutating influenza strain were to begin infecting millions of people as SARS-CoV-2 did, imagine the benefits of combining an intranasal vaccine, which could stop most infections from occurring, with a strong antibody-based vaccine shot. The impact on human health could be unequalled in our history.” The randomized, double-blind, placebo-controlled Phase 1b study, entitled FluGen H3N2 v006 (ClinicalTrials.gov NCT05163847) was designed to evaluate a monovalent Cambodia 2020 H3N2 M2SR influenza A vaccine in a healthy, older adult population. The study enrolled over 300 subjects in four cohorts receiving either M2SR alone, high dose IIV alone, both vaccines concomitantly or placebo. The primary endpoint was to assess the safety and tolerability of a single dose of monovalent M2SR influenza vaccine delivered intranasally alone or concomitantly with high dose IIV delivered intramuscularly to healthy subjects 65 to 85 years of age. Secondary endpoints included evaluation of serum and mucosal antibody responses to matched and drifted strains of influenza virus following monovalent M2SR influenza vaccine delivered intranasally alone or concomitantly with high dose IIV delivered intramuscularly. Exploratory endpoints included evaluation of additional immune parameters such as T-cell responses. This work was supported by The Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, in the amount of ($11,439,843.00), through the Peer Reviewed Medical Research Program under Award Number (W81XWH-21-1-0563). Opinions, interpretations, conclusions, and recommendations are those of the author(s) and are not necessarily endorsed by The Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense. About FluGen: FluGen, Inc. is a clinical-stage vaccine company transforming vaccine efficacy in respiratory diseases. The company’s lead candidate is M2SR, a supra-seasonal, live, single-replication, intranasal flu vaccine. Unlike standard of care flu vaccines, M2SR stimulates mucosal, humoral, and cellular immunity. In an unprecedented human challenge trial, M2SR demonstrated protection against infection and illness across seven years of virus drift; and M2SR induces a durable antibody response with potential to cover an entire flu season and beyond. M2SR also has shown positive initial results as a vaccine vector for other respiratory vaccines and infectious diseases, including a COVID-19/flu combination and for RSV. For more information about FluGen, Inc., please visit Contact: Media – Paul V. Radspinner, 608-658-6095, pradspinner@flugen.com

临床结果疫苗临床2期临床1期

2022-11-09

·PRNewswire

New Data Published in the Journal of Infectious Diseases Demonstrate FluGen's M2SR Vaccine Candidate Substantially Enhances Mucosal & Serum Antibodies Against Drifted Influenza Strains

Results show FluGen's investigational intranasal M2SR vaccine addresses an important unmet need by generating serum and mucosal antibodies against highly drifted strains of the H3N2 influenza virus MADISON, Wis., Nov. 9, 2022 /PRNewswire/ -- FluGen, Inc., a clinical-stage vaccine company transforming vaccine efficacy in infectious respiratory diseases, today announced the publication of new data in the Journal of Infectious Diseases showing its investigational, high dose, intranasal H3N2 M2SR influenza vaccine candidate substantially enhanced mucosal and serum antibodies against drifted H3N2 influenza viruses. Results showed that M2SR was well-tolerated at all dose levels and may provide substantial protection against infection with highly drifted strains of H3N2 influenza. "Antigenic drift, or circulating influenza virus strains that do not match the current influenza vaccines, are a serious public health problem, and the H3N2 strain has been particularly difficult to protect against in recent years," said Yoshihiro Kawaoka, Head of the Influenza Research Institute of the University of Wisconsin-Madison, Professor of the Institute of Medical Science of the University of Tokyo, and an author of the study. "These data suggest that the intranasal M2SR vaccine evaluated in the study may provide significant advantages over existing injected influenza vaccines." The publication, entitled "Intranasal M2SR ((M2-deficient Single Replication) H3N2 Influenza Vaccine Provides Enhanced Mucosal and Serum Antibodies in Adults", detailed results of a Phase 1B, observer-blinded, dose-escalation study of sero-susceptible subjects ages 18-49 years, randomized to receive two doses (108-109 TCID50) of M2SR or placebo administered 28 days apart. The primary objective was to demonstrate safety of M2SR vaccines (ClinicalTrials.gov number NCT03999554). Specific data demonstrated that, against the Belgium2015 challenge strain, a ≥2-fold increase in MN antibodies were noted among 40% (95% CI 24.9-56.7) of subjects following a single 108 TCID50 M2SR dose and among 80.6% (95% CI 61.4-92.3) after 109 dose (P<0.001). A single 109 TCID50 dose of M2SR generated ≥4-fold HAI seroconversion against the vaccine strain in 71% (95% CI 52.0-85.8) of recipients, a proportion substantially greater than reported for the only currently licensed intranasal flu vaccine. M2SR encoding antigen from 2018-19 influenza vaccine elicited mucosal antibodies that recognized future H3N2 strains that circulated in 2021 and 2022. Cellular immune responses were also induced. These results build on previous clinical evidence which showed that an intranasal dose of FluGen's M2SR vaccine candidate protected against infection and illness from seven years of highly drifted strains of H3N2 in subjects who demonstrated a ≥2-fold increase in microneutralization (MN) antibodies to the challenge strain after vaccination. Previous studies have also demonstrated that while currently licensed influenza vaccines administered by intramuscular injection generate tremendous antibody responses only intranasal M2SR stimulates mucosal, and cellular immunity as well as serum humoral immunity. "For decades, science has struggled to address the burden of viral drift in combatting influenza, as, when the circulating strain drifts, a mismatch between the virus and current vaccine occurs, and efficacy worsens; this is particularly true with the H3N2 strain," said Paul Radspinner, President and Chief Executive Officer of FluGen. "Previous efforts to address this challenge, such as adding adjuvants or quadrupling doses, have failed to improve outcomes for either matched or drifted strains. Now, we see further clinical evidence that our intranasal M2SR influenza vaccine candidate generates strong immunological response against both matched and drifted strains and may potentially be the more effective vaccine option that can help improve how we manage influenza." About FluGen: FluGen, Inc. is a clinical-stage vaccine company transforming vaccine efficacy in respiratory diseases. The company's lead candidate is M2SR, a supra-seasonal, live, single-replication, intranasal flu vaccine. Unlike standard of care flu vaccines, M2SR stimulates mucosal, humoral, and cellular immunity. In an unprecedented challenge trial, M2SR demonstrated protection against infection and illness across seven years of virus drift; and M2SR induces a durable antibody response with potential to cover an entire flu season and beyond. M2SR also has shown activity as a vaccine vector for other respiratory vaccines and infectious diseases, including a COVID-19/flu combination. For more information about FluGen, Inc., please visit . About M2SR: The M2 Deleted Single Replication Live Virus Vaccine (M2SR) offers a potentially differentiating clinical value proposition. FluGen's flu vaccine candidate is developed differently from inactivated or "killed" vaccines, which are comprised of flu viruses grown in eggs, chopped up, and purified for injection. It stimulates mucosal, humoral, and cellular immunity, and offers unprecedented efficacy against infection and illness across seven years of virus drift and documented immune response for at least six months. SOURCE FluGen Inc

疫苗抗体

2022-10-29

·医药笔记

美国流感季提前来临

▎Armstrong根据美国CDC的监测数据，今年的流感季似乎提前来临，本周出现了2022-2023流感季首例流感相关的儿童死亡病例，CDC估计累计第42周（本周）住院率为2010-2011流感季以来同期最高。下图为近5个月来美国临床实验室报告的流感检测阳性率数据。下表为第42周流感监测的亚型分析数据，主要为A型流感，主要亚型为（H1N1）pdm09和H3N2。下图为2017-2018年以来流感季的同期对比图，可以更清晰地看到今年流感季提前到来的趋势，至少提前了一个月。此次流感爆发主要从南部和东南部各州开始。下图为2015-2016流感季以来累计住院率的同期数据对比图。下图为2019-2020流感季以来流感死亡率数据。总结下图为2019年以来肺炎、流感、新冠死亡率数据。从图中可以看到，2020、2021、2022年新冠造成的死亡在三者之中占主要部分，2022年以来随着Omicron的流行，死亡率已经大幅下降。----------------------感兴趣的读者可以加入“医药笔记”知识星球。Armstrong技术全梳理系列GPRC5D靶点全梳理；CD40靶点全梳理；CD47靶点全梳理；补体靶向药物技术全梳理；补体药物：眼科治疗的重要方向；Claudin 6靶点全梳理；Claudin 18.2靶点全梳理；靶点冷暖，行业自知；中国大分子新药研发格局；被炮轰的“me too”；佐剂百年史；胰岛素百年传奇；CUSBEA：风雨四十载；中国新药研发的焦虑；中国生物医药企业的研发竞争；中国双抗竞争格局；中国ADC竞争格局；中国双抗技术全梳理；中国ADC技术全梳理；Ambrx技术全梳理；Vir Biotech技术全梳理；Immune-Onc技术全梳理；科济药业技术全梳理；恺佧生物技术全梳理；同宜医药技术全梳理；百奥赛图技术全梳理；腾盛博药技术全梳理；创胜集团技术全梳理；永泰生物技术全梳理；中国抗体技术全梳理；德琪医药技术全梳理；德琪医药技术全梳理2.0；和铂医药技术全梳理；荣昌生物技术全梳理；再鼎医药技术全梳理；药明生物技术全梳理；恒瑞医药技术全梳理；豪森药业技术全梳理；正大天晴技术全梳理；吉凯基因技术全梳理；基石药业技术全梳理；百济神州技术全梳理；百济神州技术全梳理第2版；信达生物技术全梳理；信达生物技术全梳理第2版；中山康方技术全梳理；复宏汉霖技术全梳理；先声药业技术全梳理；君实生物技术全梳理；嘉和生物技术全梳理；志道生物技术全梳理；道尔生物技术全梳理；尚健生物技术全梳理；康宁杰瑞技术全梳理；科望医药技术全梳理；科望医药技术全梳理2.0；岸迈生物技术全梳理；礼进生物技术全梳理；康桥资本技术全梳理；余国良的抗体药布局；荃信生物技术全梳理；安源医药技术全梳理；三生国健技术全梳理；仁会生物技术全梳理；乐普生物技术全梳理；同润生物技术全梳理；宜明昂科技术全梳理；派格生物技术全梳理；迈威生物技术全梳理；Momenta技术全梳理；NGM技术全梳理；普米斯生物技术全梳理；普米斯生物技术全梳理2.0；三叶草生物技术全梳理；贝达药业抗体药全梳理；泽璟制药抗体药全梳理；恒瑞医药抗体药全梳理；齐鲁制药抗体药全梳理；石药集团抗体药全梳理；豪森药业抗体药全梳理；华海药业抗体药全梳理；科伦药业抗体药全梳理；百奥泰技术全梳理；凡恩世技术全梳理。

抗体抗体药物偶联物

100 项与 H3N2 M2SR influenza vaccine (FluGen) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
流感病毒感染	临床1期	美国	FluGen, Inc.	2016-06-01
甲型流感病毒感染	药物发现	比利时	FluGen, Inc.	2018-04-28

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04785794 (CTgov)	临床1期	流感病毒感染	122	Sing2016 M2SR H3N2 influenza vaccine (M2SR Dose, 50-64 Years of Age)	餘選夢顧醖願鏇範壓壓(淵願鏇憲構膚願製醖壓) = 蓋憲鹹齋窪積糧繭淵鬱構築艱齋範鑰鹹齋鬱衊 (壓獵範蓋淵遞願顧簾襯, 繭範網繭夢鏇憲鬱糧積 ~ 顧憲齋獵鬱範壓窪醖簾) 更多	-	2023-06-15
				Placebo (Placebo Dose, 50-64 Years of Age)	餘選夢顧醖願鏇範壓壓(淵願鏇憲構膚願製醖壓) = 構選願顧鬱顧鏇膚繭齋構築艱齋範鑰鹹齋鬱衊 (壓獵範蓋淵遞願顧簾襯, 顧糧醖構範膚糧鹹齋簾 ~ 憲觸觸壓淵觸觸製襯齋) 更多
NCT03999554 (CTgov)	临床1期	甲型流感病毒感染	206	LD Bris10 M2SR H3N2 influenza vaccine (Low Dose Bris10 M2SR)	願選遞艱糧簾選積鑰製(衊製蓋廠糧構淵鬱製網) = 廠觸鏇餘願鏇選鬱鹹淵鏇構繭醖餘構願鏇餘鑰 (繭夢鑰鹽醖衊壓齋蓋艱, 襯鏇憲鬱鏇衊醖糧夢襯 ~ 糧齋網選製淵鹽繭窪製) 更多	-	2022-03-04
				Placebo (Placebo)	願選遞艱糧簾選積鑰製(衊製蓋廠糧構淵鬱製網) = 鬱齋窪構鹹壓獵鏇蓋網鏇構繭醖餘構願鏇餘鑰 (繭夢鑰鹽醖衊壓齋蓋艱, 齋願築鬱鹹獵廠築顧蓋 ~ 夢鹹醖襯觸壓鬱製鏇衊) 更多