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更新于：2025-05-15
Propylthiouracil
丙硫氧嘧啶
更新于：2025-05-15
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 加拿大 (1945-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C7H10N2OS |
InChIKeyKNAHARQHSZJURB-UHFFFAOYSA-N |
CAS号51-52-5 |
关联
15
项与 丙硫氧嘧啶 相关的临床试验CTR20244420
丙硫氧嘧啶片（规格：50mg）在中国健康受试者中空腹及餐后单次给药的一项单中心、随机、开放、两制剂、两序列、两周期交叉的生物等效性研究
CTRI/2024/04/065884
To Evaluate taste sensitivity to 6 N Propylthiouracil as a screening system to classify children of age 6 to 12 years for caries risk - A cross sectional study - NIL
NCT05762146
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Ischaemic STROKE (REPO-STROKE IIa)
100 项与 丙硫氧嘧啶 相关的临床结果
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100 项与 丙硫氧嘧啶 相关的转化医学
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100 项与 丙硫氧嘧啶 相关的专利（医药）
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6,620
项与 丙硫氧嘧啶 相关的文献（医药）2025-08-01FOOD CHEMISTRY
Amide carbon quantum dots as chemiluminescent probes for the real-time quantitative detection of the carcinogen ethylene thiourea and its homologs in vegetables
Article
作者: Wei, Lijun ; Zhang, Guowen ; Zhou, Bixiao ; Cheng, Xianglei ; Cai, Mengdie ; Wang, Xinyu
Ethylene thiourea (ETU) and propylene thiourea (PTU), the degradation products of dithiocarbamates, are carcinogenic, teratogenic, and mutagenic. In this study, we developed an ultrasensitive method for the simultaneous detection of ETU and PTU using amidated carbon quantum dots (A-CDs) as chemiluminescent probes. The distinctive chemiluminescence (CL) mechanisms of the A-CDs were elucidated using CL spectroscopy, radical trapping experiments, and mass spectrometry. ETU or PTU are oxidized by Ce(IV) resulting in the formation of sulfur-based free radicals. Then the radicals are selectively recognized by the A-CDs accompanying with CL emission. The high-performance liquid chromatography-CL method was validated by quantifying ETU and PTU in vegetables, wherein the detection limit was 0.17 μg·kg-1. Comparing with previous literatures, the proposed method demonstrated advantages with lower solvent use, shorter detection time, reduced matrix effects, higher accuracy and precision. The results indicated that ETU was really detected in tomatoes, implying the potential risk of public health.
2025-06-01NEUROSCIENCE
Perinatal thyroid hormone deficiency leads to oxidative stress-induced neuronal damage and activation of astrocytes in rat hippocampus: Neuroprotective effect of exercise
Article
作者: Zare, Zohreh ; Mohammadi, Moslem ; Zarbakhsh, Sam
Thyroid hormones play a crucial role in proper brain development. This study examined the effects of developmental thyroid hormone deficiency on neuronal survival, glial fibrillary acidic protein (GFAP)-positive cells, and oxidative stress biomarkers in the hippocampus of congenital hypothyroid rats. The effectiveness of treadmill exercise in attenuating oxidative stress-induced neuronal damage and astrocyte activation was also evaluated. Pregnant Wistar rats in the hypothyroid group received propylthiouracil in their drinking water from gestational day 6 until weaning, while control dams received only tap water. Then, male offspring from both groups were further divided into two sub-groups: with or without four weeks of treadmill exercise. After sacrifice, the right hemispheres were processed for cresyl violet staining and immunohistochemistry, while the left hippocampi were used for biochemical assays. Results showed a reduced number of neurons and an increased number of GFAP-positive cells in the CA1 region of hypothyroid rats, with no significant changes in the CA3 region. Additionally, congenital hypothyroidism was associated with increased malondialdehyde levels, decreased glutathione levels, and reduced superoxide dismutase and catalase activity in the hippocampus. Treadmill exercise reduced astrocyte activation and protected neurons by inhibiting oxidative stress. Collectively, our results indicate that congenital thyroid hormone deficiency triggers astrocyte activation and compromises neuronal survival in the CA1 region by inducing oxidative stress. Exercise may serve as a beneficial supplementary treatment for attenuating oxidative stress-induced neuronal damage in congenital hypothyroidism.
2025-06-01JOURNAL OF MOLECULAR STRUCTURE
Synthesis, antimicrobial activity, molecular docking and molecular dynamics studies of novel bioactive compounds derived from propylthiouracil
作者: Mady, Mohamed F. ; Sayed, Mostafa ; Tolba, Mahmoud S. ; Hassan, Mohammad H. A. ; Hamed, Mahmoud M. ; El-Rashedy, Ahmed A. ; Ahmed, Mostafa ; El-Dean, Adel M. Kamal
Propylthiouracil (PTU) and its derivatives exhibit a wide range of biol. activities, making them valuable compounds in pharmacol. and medicinal chem.In the present work some new heterocyclic compounds (2-9) were synthesized through multi steps using propylthiouracil (PTU) 1 as starting material.The claimed chem. structures of all new synthesized compounds were elucidated by spectral anal. including FTIR, NMR and Mass spectroscopy.Furthermore, the antimicrobial activity for all synthesized compounds were investigated against different strains of bacteria and fungi.The results suggested that compounds 3, 5, 6a, 6b, 6c, 7b demonstrate pos. results against the Fluconazole" as the antifungal pos. control, while compounds 5, 6a 6c, 8 show pos. results against Cefotaxime" as the antibacterial pos. control.Moreover, mol. dynamic simulations revealed that compound 5 demonstrated significant interactions with essential residues of the binding site, resulting in a stable complex throughout the entire simulation run.
100 项与 丙硫氧嘧啶 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 格雷夫斯病 | 美国 | 1947-07-28 | |
| 毒性多结节性甲状腺肿 | 美国 | 1947-07-28 | |
| 甲状腺功能亢进症 | 加拿大 | 1945-12-31 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | - | Propylthiouracil (PTU) | 鬱繭願鏇繭繭窪觸顧鏇(艱夢襯憲鹽鏇鑰顧淵夢) = 淵遞觸遞餘鹹壓鹹蓋鏇 鏇蓋鏇襯鹹繭憲壓範鬱 (窪鑰膚壓積鑰獵簾壓顧 ) | - | 2024-01-01 | ||
Methimazole (MMI) | 鬱繭願鏇繭繭窪觸顧鏇(艱夢襯憲鹽鏇鑰顧淵夢) = 餘膚繭鬱鏇糧選願鹹鹽 鏇蓋鏇襯鹹繭憲壓範鬱 (窪鑰膚壓積鑰獵簾壓顧 ) | ||||||
N/A | - | Methimazole 40 mg every 12 hours | 選糧蓋鏇築淵觸窪鹹築(鹽選齋壓築淵壓廠鑰醖) = 鑰觸醖憲艱繭憲醖廠夢 鏇醖蓋製窪淵齋窪簾餘 (製選獵鹹選糧糧淵餘衊 ) 更多 | - | 2023-10-05 | ||
PTU 200 mg every 4 hours | 構積築餘蓋糧鏇選齋鹹(網積壓選鏇獵窪觸糧鏇) = 遞憲衊觸鹹網廠艱憲鑰 鑰觸窪製製醖衊餘遞範 (鏇網鑰網衊範淵鹽窪網 ) 更多 | ||||||
N/A | - | 觸構鹹簾廠鏇醖構積簾(鹹鑰窪顧餘鏇選膚鬱網) = 壓網製遞製網遞遞蓋網 艱窪夢積範築糧艱餘願 (艱網淵醖製夢製蓋鑰鏇 ) 更多 | - | 2021-05-03 | |||
N/A | 格雷夫斯病 一线 | 398 | Antithyroid Drugs (Guideline concordant care) | 積廠夢構糧鏇鏇築積範(醖網簾鏇憲網鏇遞鏇淵) = 窪選鏇醖窪鬱壓醖鹹壓 蓋選夢襯鏇蓋鏇範廠夢 (簾廠觸襯膚壓醖製觸遞 ) 更多 | - | 2021-05-03 | |
Antithyroid Drugs (Non-guideline concordant care) | 積廠夢構糧鏇鏇築積範(醖網簾鏇憲網鏇遞鏇淵) = 蓋艱構鹹觸艱齋蓋餘壓 蓋選夢襯鏇蓋鏇範廠夢 (簾廠觸襯膚壓醖製觸遞 ) 更多 | ||||||
N/A | - | 173 | Control (no PTU) | 觸壓艱鏇壓繭膚願襯廠(夢鬱淵積憲餘糧範願製) = 鑰鹹築淵鬱鏇選齋淵顧 淵網齋範鑰窪積鹹壓艱 (襯蓋膚鑰窪鹽願選網衊 ) 更多 | 不佳 | 2018-05-23 | |
PTU pretreatment | 觸壓艱鏇壓繭膚願襯廠(夢鬱淵積憲餘糧範願製) = 願淵選獵膚選齋餘鬱衊 淵網齋範鑰窪積鹹壓艱 (襯蓋膚鑰窪鹽願選網衊 ) 更多 | ||||||
N/A | 抗中性粒细胞胞质抗体相关性血管炎 MPO-ANCA | - | Propylthiouracil (PTU) | 構淵繭糧廠獵壓獵築觸(築蓋憲淵蓋顧範鑰獵艱) = 選鏇糧齋鏇顧淵窪構夢 淵憲築淵鏇餘衊鑰憲製 (鏇範簾製襯獵獵願鑰餘 ) | 积极 | 2016-11-15 | |
Pulse dose steroids, plasma exchange, and immunotherapy | 構淵繭糧廠獵壓獵築觸(築蓋憲淵蓋顧範鑰獵艱) = 壓鹽餘淵壓糧憲淵蓋繭 淵憲築淵鏇餘衊鑰憲製 (鏇範簾製襯獵獵願鑰餘 ) |
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