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更新于：2025-04-05
Cloxacillin Sodium
氯唑西林钠
更新于：2025-04-05
概要
基本信息
在研机构 |
最高研发阶段批准上市 |
首次获批日期 加拿大 (1963-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C19H20ClN3NaO6S |
InChIKeyKNNWTOJBVOKDPC-VICXVTCVSA-N |
CAS号7081-44-9 |
关联
9
项与 氯唑西林钠 相关的临床试验IRCT20220310054247N1
Investigating the effect of a topical gel containing Sumac extract and Cloxacillin on diabetic foot ulcer: a double-blind placebo-controlled trial
NCT04141787
Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial
IRCT20120215009014N272
Effect of using Cloxacillin as an Antibiotic Lock Solution versus placebo on prevention of catheter-associated infection in hemodialysis patients: a single-blind randomized clinical trial
100 项与 氯唑西林钠 相关的临床结果
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100 项与 氯唑西林钠 相关的转化医学
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100 项与 氯唑西林钠 相关的专利（医药）
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4,983
项与 氯唑西林钠 相关的文献（医药）2025-05-01DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Performance of two combination disk methods as confirmation for ESBL and AmpC presence in clinical Enterobacterales isolates
Article
作者: Bode, L G M ; Klaassen, C H W ; Zandijk, W H A ; Doornekamp, L ; Goessens, W H F
PURPOSE:
Guidelines recommend the use of a combination disk method (CDM) including cefepime and clavulanic acid as a confirmation method for ESBL detection. However, an alternative CDM containing cloxacillin (combining ceftazidime and cefotaxime with clavulanic acid and/or cloxacillin), is not only able to confirm ESBL presence, but also to provide information about AmpC production. We aim to show non-inferiority of the cloxacillin-CDM compared to the cefepime-CDM.
METHODS:
We collected 102 individual clinical Enterobacterales isolates that were positive in the ESBL screening with the VITEK II. Phenotypic confirmation was performed with a cefepime-CDM and a cloxacillin-CDM (Rosco®). These results were compared with the results of a multiplex ESBL real-time PCR and an in-house developed conventional AmpC PCR.
RESULTS:
Twenty-eight% of the isolates were positive in the ESBL PCR (CTX-M, SHV-2, TEM-3). The results of cefepime-CDM and cloxacillin-CDM were concordant with the ESBL PCR in respectively 99 and 94 %. The cefepime-CDM had a sensitivity of 100 % (95 % confidence interval (CI) 88,1-100) and specificity of 98,6 % (95 % CI 92,6-100). The cloxacillin-CDM had a sensitivity of 96,6 (95 % CI 82,2-99,9) and a specificity of 93,2 % (95 % CI 84,7-97,7). The cloxacillin-CDM in the group I Enterobacterales compared to the AmpC PCR had a sensitivity of 92 % (95 % CI 62-100) and a specificity of 100 % (95 % CI 77-100).
CONCLUSION:
Both cefepime-CDM and cloxacillin-CDM performed well as ESBL confirmation methods. Therefore, we suggest to add the cloxacillin-CDM as an alternative ESBL confirmation method to AMR detection guidelines in clinical settings.
2025-04-01Global Spine Journal
Predictive Factors of Cloxacillin Susceptibility in Primary Bacterial Spinal Infection
Article
作者: Ho, Pak Leung ; Tang, Chris Yuk Kwan
Study Design:
Prognostic study.
Objectives:
The objective of this study is to identify predictive factors for cloxacillin susceptibility in spinal infections.
Methods:
A retrospective analysis was conducted using data from January 1, 1997, to December 31, 2021. The study included patients presenting with back pain and either a positive bacterial culture from the spine or radiological evidence of spinal infection (spondylodiscitis and/or epidural abscess) along with positive bacterial blood culture.
Results:
Among 171 patients (127 males, 44 females), 53.2% had
Staphylococcus
isolates, with 40.4% showing cloxacillin resistance. Lower globulin levels (<33.5 g/L), recent hospitalization within 90 days, and residence in an old age home predicted gram-positive bacteria with cloxacillin resistance and gram-negative bacteria as causative organisms (
P
<.05). The 30-day and 1-year all-cause mortality rates were 0% and 8.2%, respectively. Higher red cell distribution width (RDW >16.1%) and Charlson comorbidity index (CCI) scores predicted 1-year all-cause mortality (
P
<.05). Intensive care unit admission was required for 9.9% of patients.
Conclusions:
This study identified predictive factors for spinal infection by gram-positive bacteria with cloxacillin resistance and gram-negative bacteria. Patients with lower globulin levels (<33.5 g/L), recent hospitalization within 90 days, or residency in an old age home upon admission should avoid standalone cloxacillin therapy and consider antibiotics with gram-negative coverage. Higher RDW (>16.1%) and CCI scores were associated with increased 1-year all-cause mortality. These findings contribute to treatment decision-making and improving patient outcomes in spinal infections.
2025-03-01Global spine journal
Antibiotic Use in Adult Spine Deformity Surgery: Results From the AO Spine Surveillance of the Management of Patients With Adult Spine Deformity
Article
作者: Lenke, Lawrence G. ; Lewis, Stephen J. ; Kato, So ; Shaffrey, Christopher I. ; Rocos, Brett
Study Design:
Cross-sectional international survey with literature review.
Objectives:
To evaluate the evidence for these strategies and to understand the current trends in prophylactic antibiotic use during ASD surgery through an international survey.
Methods:
An online survey was conducted among international AO Spine members regarding the peri-operative management of patients with ASD. The details of perioperative systemic and topical antibiotic use were solicited. Descriptive data were summarized for the responding surgeons who perform at least 10 long-segment fusions of >5 levels extending to the pelvis annually.
Results:
The literature supports the use of prophylactic antibiotic effective against gram positive organisms. The use of topical vancomycin remains debated, and there is limited evidence for topical tobramycin use. A total of 116 responses were received. 74 (64%) surgeons use topical vancomycin, most usually deep to the fascia only 45 (61%). The most usual dose used is 1-2 g. 4 (3%) surgeons use topical tobramycin deep to fascia. Following surgery, 90 (78%) surgeons use prophylactic cephalosporin with 3 (3%) using cloxacillin, 5 (4%) using ciprofloxacin and 9 (8%) using vancomycin and 6 (5%) using clindamycin either in addition or alone.
Conclusions:
The present survey identifies a trend towards systemic and topical antibiotic prophylaxis primarily targeted at gram positive pathogens. The use of topical tobramycin, proposedly effective against gram negative infections, remains uncommon. There is a lack of consensus in the selection of perioperative antibiotic prophylaxis, thus a prospective study of the rates of infection with each strategy would be useful to inform guidelines.
100 项与 氯唑西林钠 相关的药物交易
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 葡萄球菌感染 | 加拿大 | 1963-12-31 |
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