更新于：2024-06-20

Choline bitartrate

重酒石酸胆碱

更新于：2024-06-20

概要

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段-

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C9H19NO7

InChIKeyQWJSAWXRUVVRLH-LREBCSMRSA-M

CAS号87-67-2

关联

项与重酒石酸胆碱相关的临床试验

PACTR202310844349932 / SuspendedN/AIIT

Acceptability of Super Cereal Plus with added choline in Malawian children

开始日期2023-10-31

申办/合作机构

Washington University in St. Louis

PACTR202310496960868 / SuspendedN/AIIT

Acceptability of a ready-to-use therapeutic food with added choline in Malawian children

开始日期2023-10-30

申办/合作机构

Washington University in St. Louis

IRCT20191104045328N16 / Suspended临床3期

The effect of choline supplementation on biometric parameters of fetal growth and glycemic index in women with gestational diabetes

开始日期2023-10-22

申办/合作机构

Arak University of Medical Sciences

100 项与重酒石酸胆碱相关的临床结果

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100 项与重酒石酸胆碱相关的转化医学

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100 项与重酒石酸胆碱相关的专利（医药）

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项与重酒石酸胆碱相关的文献（医药）

2024-01-01·Semergen

Importancia de la colina durante el embarazo y lactancia. Una revisión sistemática

Review

作者: Heras-Sola, J ; Gallo-Vallejo, J L

Pregnancy is one of the most important and difficult moments that a woman goes through throughout her life. It is a period of great need for macro and micronutrients to meet the demands of the developing fetus and avoid deficiencies, in order to obtain the best possible result. Nowadays, most women who are pregnant or planning to become pregnant know the importance of getting the required amount of certain types of nutrients (proteins, fats, folate, etc.), as well as avoiding certain compounds (alcohol, tobacco, drugs, etc.) to avoid possible complications during pregnancy. In recent years, with the greatest scientific evidence available, it has been shown how some of these nutrients could have a more relevant role than previously believed in the optimal outcome of pregnancy. One of these nutrients being choline. Choline supplementation during pregnancy has been shown to be a non-pharmacological treatment capable of improving both physical (growth) and mental (memory) qualities of the new individual. Choline has been known as an essential nutrient since 1998 and several studies have shown its effectiveness in rodent models. The existence of recent publications that deal with its application in humans makes it necessary to carry out a systematic review. In this systematic review of the scientific evidence available from 2012 to the present that deals with the application of a higher intake of choline through supplementation as a treatment to improve pregnancy outcomes, its main objetive is to determine the effects that a nutritional intervention through choline supplementation in pregnant mothers can have on children's cognition. For this, 9studies have been analyzed where the treatment given to pregnant women is revealed, this being choline supplementation in different modalities (choline chloride, choline bitartrate, and phosphatidylcholine) and the different effects produced in the children of these mothers who have resulted from these treatment modalities. We conclude by stating that choline supplementation during pregnancy appears to be effective in improving or increasing cognition in children.

2023-02-01·Poultry science

Article

作者: Bobeck, E A ; Meyer, M M

Woody breast has become a considerable economic concern to the poultry industry. This myopathy presents rigid, pale breasts characterized by replacement of lean muscle protein with connective tissue, a result of hypoxia and oxidative stress in a metabolically starved muscle with inadequate circulation. Hence, the objectives were to supplement broiler diets with ingredients specifically aimed to improve circulation and oxidative status. About 1,344 male Ross 708 broilers were assigned to 1 of 4 diets: 1) a basal diet (control), 2) basal diet plus a blend of 0.2% supplemental L-arginine, 0.17% choline bitartrate, and 0.03% vitamin C (blend), 3) 0.1% vasodilator ingredient (vasodilator), or 4) 0.02% Astaxanthin ingredient (AsX). At d 14, 28, 42, and 49, performance outcomes were collected on all birds and serum from 16 broilers/diet (n = 64) was analyzed for creatine kinase and myoglobin. Once weekly beginning on d 28, a subset of 192 broilers were measured for breast width. On d 42 and 49, breast fillets from 16 broilers/diet (n = 64) were palpated for woody breast severity, weighed, and analyzed for compression force at 1-day postmortem and water-holding capacity at 2-day postmortem. mRNA was isolated from 15 breast fillets/timepoint for qPCR quantification of myogenic gene expression. Data were analyzed using Proc Mixed (SAS Version 9.4) with the fixed effect of diet. Feed conversion ratio was improved in the blend and vasodilator-fed birds d 42 to 49, each by over 2 points (P < 0.05). Breast width was increased in the control on d 42 compared to the vasodilator and AsX-fed broilers (P < 0.05). At d 42, there were 12% greater normal fillets in blend diet-fed birds and 13% more normal scores in vasodilator-fed birds at d 49 compared to the control. At d 49, myogenin expression was upregulated in the AsX diet compared to blend and control diets (P < 0.05), and muscle regulatory factor-4 expression was increased by 6.5% in the vasodilator diet compared to the blend and AsX diets (P < 0.05). Blend and vasodilator diets simultaneously improved feed efficiency in birds approaching market weight while reducing woody breast severity.

2023-01-01·Frontiers in endocrinology

Review

作者: Santulli, Gaetano ; Lombardi, Angela ; Trimarco, Valentina ; Varzideh, Fahimeh ; Kansakar, Urna ; Mone, Pasquale

In this comprehensive review, we examine the main preclinical and clinical investigations assessing the effects of different forms of choline supplementation currently available, including choline alfoscerate (C₈H₂₀NO₆P), also known as alpha-glycerophosphocholine (α-GPC, or GPC), choline bitartrate, lecithin, and citicoline, which are cholinergic compounds and precursors of acetylcholine. Extensively used as food supplements, they have been shown to represent an effective strategy for boosting memory and enhancing cognitive function.

项与重酒石酸胆碱相关的新闻（医药）

2024-03-21

·PRNewswire

GO BEYOND HEALTHY HYDRATION WITH SALTHEAD™ - AVAILABLE AT NUTRISHOP

New advanced electrolyte formula appeals to those looking to fuel their body and mind HENDERSON, Nev., March 21, 2024 /PRNewswire/ -- NUTRISHOP® continues to lead the way in nutritional supplement innovation with its latest offering from Xcelerated Performance Products® (XP2): SALTHEAD™. This product's advanced formula goes beyond standard electrolyte replenishment with its inclusion of 100% Pink Himalayan Salt, 72 trace minerals, and a generous dose of the brain-boosting nootropic Choline Bitartrate. In a world where dehydration often goes unnoticed, SALTHEAD emerges as a smart solution for your body and mind. Continue Reading "SALTHEAD bridges the gap between healthy hydration and overall vitality," Bryon McLendon, founder and CEO of Nutrishop. Post this Redefine your hydration and health routine with& SALTHEAD,& available exclusively at& Nutrishop locations nationwide& and& NutrishopUSA.com. You see, hydration is not just about water—it's about mineralization. Merely having water in your body doesn't guarantee hydration; it's about ensuring that the water reaches your tissues. This is where electrolytes come into play. However, not all electrolyte formulas are created equal. "SALTHEAD bridges the gap between healthy hydration and overall vitality and is a testament to our commitment to innovation, quality, and the well-being of our customers," said Bryon McLendon, Nutrishop's founder and CEO. "This product is not just for athletes or fitness enthusiasts, it's for anyone looking to improve their health and wellness game." Christina Hubacek, a dedicated firefighter from Mesquite, TX, praises SALTHEAD's effectiveness: "It's definitely a game-changer for me and has become an important part of my daily routine, ensuring I stay hydrated and energized." Why Choose SALTHEAD? Next-Level Hydration: As an electrolyte formula, SALTHEAD goes beyond water alone. "A lot of people think that just drinking water equals hydration. But, it's the electrolytes that matter—they're the real MVPs, making sure the water you drink actually does its job hydrating your cells properly," explained Jay Vicino, franchisee of the Mt. Juliet Nutrishop store in Tennessee. Unmatched Formula: Each serving of SALTHEAD contains 1,000mg of 100% Pink Himalayan Salt, which circumvents the potentially harmful effects of microplastics that may be found in some of the other forms of salt in circulation today. SALTHEAD also includes 1.5g of Choline Bitartrate (yielding 600mg of choline) and 72 Ionic Trace Minerals, which support internal bodily processes while contributing to overall health. Mental-Edge Boost: Choline is a highly sought-after ingredient known for supporting cognitive function. "Choline is essential for our everyday lives, but most people don't consume an adequate amount through whole foods or supplementation," Vicino, who is ISSA-certified in fitness nutrition, said. "SALTHEAD helps ensure you are getting enough Choline and then some!" No Unnecessary Additives: Unlike some electrolyte formulas available today, SALTHEAD contains no artificial sweeteners or synthetic colors, prioritizing health above all. Taste Matters: Available in Salty Watermelon and Salty Raspberry flavors, SALTHEAD provides a refreshingly tasty way to stay hydrated, healthy, and replenished. Look for a new flavor to come out later this year! "I love SALTHEAD because I can actually feel it working, which is something I haven't had with other products I've tried," said Ayme Salas, of Nashville, TN. "And it tastes great, too!" Get SALTHEAD today! Ready to redefine your hydration and health routine? SALTHEAD is available exclusively at Nutrishop locations nationwide and can be conveniently purchased online at NutrishopUSA.com. Remember, it's not just about drinking fluids; it's about ensuring your body is fully nourished, hydrated, and ready to perform at its best – no matter what your day brings. About Xcelerated Performance Products® (XP2): Xcelerated Performance Products® (XP2) is at the forefront of nutritional science, developing high-quality supplements that empower individuals to achieve optimal health and performance. With a relentless commitment to innovation, XP2 continues to introduce products that set new standards in the supplement industry. About NUTRISHOP® Since 2003, Nutrishop has helped countless individuals live a fit, healthy, happy lifestyle. Nutrishop stores offer customers a low-price guarantee on a wide array of cutting-edge dietary supplements, exceptional, individualized customer service, easy-to-follow meal plans, body composition assessment tools, and sound nutritional guidance. The Nutrishop business model focuses primarily on franchisee-owned and operated stores that provide consumers with the tools to achieve their health and fitness goals. For more information, visit NutrishopUSA.com and follow on Instagram @NutrishopUSA. To learn more about becoming a Nutrishop franchisee, visit NutrishopFranchise.com. SOURCE Nutrishop

2023-06-29

·PRNewswire

Oomph Body's Natural Sleep Aids Beat Pharmaceutical Alternatives

The Health Brand's Innovative Nutraceutical Medical Foods Offer Sweet, Safe Relief From Sleep Deprivation FORT LAUDERDALE, Fla., June 29, 2023 /PRNewswire/ -- Insomnia is a common struggle. As much as 33% of adults struggle with significant sleep deprivation, while one in 10 adults is considered to have chronic insomnia as a medical condition. Many individuals resort to strong chemical prescriptions to address their stressed-out sleep. But Sleep Foundation reports nearly twenty different potential side effects that come from taking sleep medications, including nausea, dizziness, and even uncontrollable shaking. Mayo Clinic also lists 11 different kinds of chemically-based sleep meds that either help you fall asleep or stay asleep — nearly all of which can develop dependencies. This struggle between insomnia and the side effects of sleep medications is what led the health and wellness brand Oomph Body to develop its Lights Out and Deep Sleep aminos products. Both dietary supplements use natural ingredients like GABA and Choline Bitartrate to help improve quality of sleep and parasympathetic nervous system function, respectively, leading to a better night's sleep. "We created Oomph Body because simply trying to 'be healthy' isn't enough," says company co-founder and CEO Scott Sharp. "We wanted to help people reach their fullest potential. That's why our go-to saying is that we help you 'Thrive at the Speed of Life.'" Sharp is a retired professional racecar driver that has spent his life pursuing health and wellness at top speeds. The CEO goes on to add that while thriving often means maximizing energy and output, sometimes it has to do with optimizing recovery, too. "Our sleep aid range is designed to help you rest and recharge — like, really rest and recharge. They're a medical food that ensures you aren't wasting your downtime. Clinically-proven medical food is slightly different from traditional vitamins. It is a distinct category of FDA-regulated products that helps with the specific and unique requirements of those managing a chronic disease. They use science and clinical research to focus on supporting and addressing underlying metabolic changes. "When we went to market our Deep Sleep and Lights Out aminos products," explains Sharp's co-founder and Oomph Body president, Dan Austin, "we wanted to test them to see how they held up against the stronger chemical alternatives — you know, the stuff like Zolpidem, which is used in Ambien. We wanted to see how our natural food-based formulations measured up against the kind of insomnia drugs that people don't want to become overly reliant on. Our medical foods went head-to-head against Ambien and won." As is the case with all of Oomph Body's supplements, Deep Sleep and Lights Out offer the brand's customers a clean, natural alternative to harmful pharmaceutical-grade products. They offer a drug-free, non-addictive way to safely address the struggle to sleep. And yet, they don't require a compromise with potency. A rarity in the nutraceutical world, Oomph Body's sleep-focused medical foods provide consumers with a way to safely get a great night's sleep with no side effects. "If you want to thrive," says Sharp, "You need your rest. Our products deliver on that need without risking other areas of your health in the process." About Oomph Body Oomph Body is a nutraceutical developer and manufacturer that is owned by professional race car driver Scott Sharp and tech and wellness industries alumni Dan Austin. Together, the dynamic duo is blazing a new trail for nutraceuticals by developing groundbreaking formulas that combine innovative, synergistic ingredient blends to create effective results in those looking to care for their minds and bodies. All Oomph Body products are formulated and manufactured in the U.S. Learn more at oomphbody.com. Contact: Scott Sharp 561-914-1888 [email protected] SOURCE Oomph Body

2023-03-16

·国家药品监督管理局政务服务门户

2023年03月16日药品批准证明文件送达信息发布

2022年11月1日起，行政相对人可登录网上办事大厅的法人空间查看电子证照，按照相关提示自行打印。序号受理号药品名称申请人批准文号批准日期1CXHS2101042国盐酸右美托咪定鼻喷雾剂上海恒瑞医药有限公司国药准字H202300062023年03月15日2CYHB1950023国乳酸钠林格注射液湖南科伦制药有限公司————2023年03月13日3CYHB2050255国阿莫西林胶囊海口市制药厂有限公司————2023年03月14日4CYHB2050604国注射用头孢他啶海口市制药厂有限公司————2023年03月13日5CYHB2050605国注射用头孢他啶海口市制药厂有限公司————2023年03月13日6CYHB2050606国注射用头孢他啶海口市制药厂有限公司————2023年03月13日7CYHB2050607国注射用头孢他啶海口市制药厂有限公司————2023年03月13日8CYHB2050733国奥氮平片常州华生制药有限公司————2023年03月14日9CYHB2102192国氨酚咖那敏片苏中药业集团股份有限公司————2023年03月13日10CYHB2150807国阿奇霉素颗粒沈阳金龙药业有限公司————2023年03月14日11CYHB2150941国丙泊酚乳状注射液西安力邦制药有限公司————2023年03月14日12CYHB2150942国丙泊酚乳状注射液西安力邦制药有限公司————2023年03月14日13CYHB2151017国注射用头孢他啶海南葫芦娃药业集团股份有限公司————2023年03月13日14CYHB2151018国注射用头孢他啶海南葫芦娃药业集团股份有限公司————2023年03月13日15CYHB2151019国注射用头孢他啶海南葫芦娃药业集团股份有限公司————2023年03月13日16CYHB2151039国注射用氨苄西林钠舒巴坦钠湖南科伦制药有限公司————2023年03月11日17CYHB2151040国注射用氨苄西林钠舒巴坦钠湖南科伦制药有限公司————2023年03月11日18CYHB2151047国胞磷胆碱钠注射液华润双鹤利民药业（济南）有限公司————2023年03月11日19CYHB2151048国胞磷胆碱钠注射液华润双鹤利民药业（济南）有限公司国药准字H202370272023年03月11日20CYHB2151049国甘油果糖氯化钠注射液福建天泉药业股份有限公司————2023年03月15日21CYHB2151051国盐酸特拉唑嗪片浙江亚太药业股份有限公司————2023年03月14日22CYHB2200064国乳果糖口服溶液湖南科伦制药有限公司————2023年03月13日23CYHB2200258国硫酸镁注射液扬州中宝药业股份有限公司国药准字H202370302023年03月15日24CYHB2250145国注射用头孢哌酮钠舒巴坦钠广东金城金素制药有限公司————2023年03月13日25CYHB2250146国注射用头孢哌酮钠舒巴坦钠广东金城金素制药有限公司————2023年03月13日26CYHB2250147国注射用头孢哌酮钠舒巴坦钠广东金城金素制药有限公司————2023年03月13日27CYHB2250148国注射用头孢哌酮钠舒巴坦钠广东金城金素制药有限公司————2023年03月13日28CYHB2250181国注射用哌拉西林钠他唑巴坦钠浙江金华康恩贝生物制药有限公司————2023年03月13日29CYHB2250182国注射用哌拉西林钠他唑巴坦钠浙江金华康恩贝生物制药有限公司国药准字H202370282023年03月13日30CYHB2250183国注射用哌拉西林钠他唑巴坦钠浙江金华康恩贝生物制药有限公司————2023年03月13日31CYHB2250191国注射用醋酸卡泊芬净杭州中美华东制药有限公司国药准字H202370292023年03月13日32CYHB2250199国头孢拉定胶囊浙江昂利康制药股份有限公司————2023年03月14日33CYHB2250257国甲硝唑氯化钠注射液河北天成药业股份有限公司————2023年03月13日34CYHB2300304依那普利氢氯噻嗪咀嚼片山东宜岛康制药有限公司————2023年03月14日35CYHB2300316阿齐沙坦片成都地奥九泓制药厂————2023年03月14日36CYHB2300317阿齐沙坦片成都地奥九泓制药厂————2023年03月14日37CYHB2300318维生素C咀嚼片黑龙江宋慈制药有限责任公司————2023年03月14日38CYHB2300320西咪替丁片上海青平药业有限公司————2023年03月14日39CYHB2300322复方氨基酸注射液(6AA)安庆回音必制药股份有限公司————2023年03月14日40CYHB2300323复方氨基酸注射液(9AA)安庆回音必制药股份有限公司————2023年03月14日41CYHB2300327蛋氨酸重酒石酸胆碱片沈阳君元药业有限公司————2023年03月15日42CYHB2300332阿替洛尔片沈阳君元药业有限公司————2023年03月15日43CYHB2300334阿替洛尔片沈阳君元药业有限公司————2023年03月15日44CYHB2300339苦参素氯化钠注射液广西裕源药业有限公司————2023年03月14日45CYHB2300340苦参碱葡萄糖注射液广西裕源药业有限公司————2023年03月14日46CYHB2300341盐酸川芎嗪氯化钠注射液广西裕源药业有限公司————2023年03月15日47CYHB2300342替硝唑葡萄糖注射液广西裕源药业有限公司————2023年03月15日48CYHB2300352小儿氨酚黄那敏片广西维威制药有限公司————2023年03月14日49CYHB2300358缬沙坦氨氯地平片（I）上海雅培制药有限公司————2023年03月14日50CYHB2300359缬沙坦氨氯地平片（II）上海雅培制药有限公司————2023年03月14日51CYHB2300365度米芬含片广东瑞兴医药股份有限公司————2023年03月14日52CYHB2300367聚乙二醇4000散海口市制药厂有限公司————2023年03月14日53CYHB2300389碘海醇注射液广西裕源药业有限公司————2023年03月15日54CYHB2300390碘海醇注射液广西裕源药业有限公司————2023年03月15日55CYHB2300403维生素E烟酸酯软胶囊广东广发制药有限公司————2023年03月14日56CYHB2300414硫糖铝咀嚼片河南普瑞制药有限公司————2023年03月14日57CYHB2300421醋柳黄酮片陕西年青保制药有限公司————2023年03月14日58CYHB2300422醋柳黄酮片陕西年青保制药有限公司————2023年03月14日59CYHB2300423醋柳黄酮片陕西年青保制药有限公司————2023年03月14日60CYHB2300436硝苯地平片黑龙江亿达鸿药业有限公司————2023年03月14日61CYHS2000891国头孢克洛缓释片（Ⅱ）扬子江药业集团有限公司国药准字H202332732023年03月15日62CYHS2101117国富马酸丙酚替诺福韦片天地恒一制药股份有限公司国药准字H202332782023年03月15日63CYHS2101150国枸橼酸托法替布片福安药业集团宁波天衡制药有限公司国药准字H202332792023年03月15日64CYHS2101273国曲前列尼尔注射液江苏众强药业有限公司国药准字H202332662023年03月15日65CYHS2101309国吸入用异丙托溴铵溶液江苏康缘药业股份有限公司国药准字H202332672023年03月15日66CYHS2101348国华法林钠片上海旭东海普药业有限公司国药准字H202332682023年03月15日67CYHS2101355国吸入用复方异丙托溴铵溶液海南斯达制药有限公司国药准字H202332802023年03月15日68CYHS2101385国美沙拉秦肠溶缓释胶囊海南合瑞制药股份有限公司国药准字H202332772023年03月15日69CYHS2101427国地高辛注射液上海旭东海普药业有限公司国药准字H202332692023年03月15日70CYHS2101479国醋酸阿比特龙片上海创诺制药有限公司国药准字H202332702023年03月15日71CYHS2101526国磷苯妥英钠注射用浓溶液西安葛蓝新通制药有限公司国药准字H202332742023年03月15日72CYHS2101527国磷苯妥英钠注射用浓溶液西安葛蓝新通制药有限公司国药准字H202332752023年03月15日73CYHS2101791国注射用尼可地尔天津天士力之骄药业有限公司国药准字H202332712023年03月15日74CYHS2101792国注射用尼可地尔天津天士力之骄药业有限公司国药准字H202332722023年03月15日75CYHS2101901国尼洛替尼胶囊齐鲁制药有限公司国药准字H202332812023年03月15日76CYHS2101980国尼洛替尼胶囊齐鲁制药有限公司国药准字H202332822023年03月15日77CYHS2102045国呋塞米注射液嘉实（湖南）医药科技有限公司国药准字H202332762023年03月15日78CYSB2200077国重组结核杆菌融合蛋白（EC）安徽智飞龙科马生物制药有限公司国药准字S202370042023年03月13日79CYZB2300133小儿咳喘灵颗粒北京亚东生物制药有限公司————2023年03月14日80CYZB2300316开胸顺气丸石家庄御泽堂制药有限公司————2023年03月14日81CYZB2300317六味地黄丸石家庄御泽堂制药有限公司————2023年03月14日82CYZB2300320玄麦甘桔颗粒哈尔滨瑰宝药业有限公司————2023年03月14日83CYZB2300321芩暴红止咳合剂河南比福制药股份有限公司————2023年03月14日84CYZB2300325千金止带丸（水丸）重庆希尔安药业有限公司————2023年03月14日85CYZB2300326二十五味珍珠丸河南诺美药业有限公司————2023年03月14日86CYZB2300327二十五味鬼臼丸河南诺美药业有限公司————2023年03月14日87CYZB2300328牛黄解毒片重庆壹零柒陆医药科技有限公司————2023年03月14日88CYZB2300329抗衰灵膏云南延寿堂制药有限公司————2023年03月14日89CYZB2300330六味地黄丸云南延寿堂制药有限公司————2023年03月14日90CYZB2300331生乳片上海延安药业（湖北）有限公司————2023年03月14日91CYZB2300332胎盘片上海延安药业（湖北）有限公司————2023年03月14日92CYZB2300333百日咳片上海延安药业（湖北）有限公司————2023年03月14日93CYZB2300334三黄片通化万通药业股份有限公司————2023年03月14日94CYZB2300337咽喉消炎丸朗天药业（湖北）有限公司————2023年03月14日95CYZB2300338回生再造丸朗天药业（湖北）有限公司————2023年03月14日96CYZB2300339葛山降脂颗粒江西普正制药股份有限公司————2023年03月14日97CYZB2300344芪蓉润肠口服液北京瑞璟医药有限公司————2023年03月14日98CYZB2300345小儿清解颗粒北京瑞璟医药有限公司————2023年03月14日99CYZB2300346润肠胶囊广州琥瑞医药科技发展有限公司————2023年03月14日100CYZB2300352二十五味珊瑚丸河南诺美药业有限公司————2023年03月14日101CYZB2300355脉安颗粒安徽方达健康产业发展有限公司————2023年03月14日102CYZB2300356夜宁糖浆安徽方达健康产业发展有限公司————2023年03月14日103CYZB2300358舒肝丸国大（黑龙江）制药科技有限公司————2023年03月14日104CYZB2300359清热解毒口服液黑龙江宋慈制药有限责任公司————2023年03月14日105JTH2300051依伏卡塞对照品协和麒麟（中国）制药有限公司————2023年03月14日106JTH2300054阿那曲唑空白片阿斯利康制药有限公司————2023年03月14日107JTH2300057Ceftolozane Sulfate WS默沙东研发（中国）有限公司————2023年03月14日108JTH2300059厄他培南钠杭州默沙东制药有限公司————2023年03月14日109JTH2300061非那雄胺喷雾剂科笛生物医药（无锡）有限公司————2023年03月14日110JTH2300063Cilastatin Ammonium Salt默沙东研发（中国）有限公司————2023年03月14日111JTH2300064注射用维替泊芬欧康维视生物医药（上海）有限公司————2023年03月14日112JXHS2101000国注射用盐酸依拉环素云济华美药业（北京）有限公司国药准字HJ202331352023年03月15日113JXHS2200041国达罗他胺片拜耳医药保健有限公司国药准字HJ202100102023年03月15日114JYHB2000829国吸入用复方异丙托溴铵溶液勃林格殷格翰（中国）投资有限公司————2023年03月13日115JYHB2100085国硫酸沙丁胺醇吸入粉雾剂美纳里尼（中国）投资有限公司————2023年03月13日116JYHB2200142国丙酸氟替卡松雾化吸入用混悬液苏州亿腾药品销售有限公司————2023年03月13日117JYHB2300134磷/碳酸氢钠血滤置换液百特医疗用品贸易（上海）有限公司————2023年03月15日118JYSB2100056国重组乙型肝炎疫苗(酿酒酵母)葛兰素史克（中国）投资有限公司————2023年03月13日119JYSB2100057国重组乙型肝炎疫苗(酿酒酵母)葛兰素史克（中国）投资有限公司————2023年03月13日120JYSB2200014国阿达木单抗注射液艾伯维医药贸易（上海）有限公司————2023年03月15日121JYSB2200054国b型流感嗜血杆菌结合疫苗深圳赛诺菲巴斯德生物制品有限公司————2023年03月14日

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分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02735473 (CTgov)	临床2期	胎儿酒精谱群障碍	46	Choline bitartrate (Choline Bitartrate)	壓齋選鏇衊顧簾廠艱襯(構鏇範艱遞願繭鏇艱鑰) = 遞廠醖糧積遞艱糧鑰獵廠繭窪蓋醖蓋窪蓋簾顧 (廠淵襯鹹製範構糧構範, 膚積網餘願繭憲範淵築 ~ 簾醖獵蓋鏇襯夢網構觸) 更多	-	2022-11-01
				Placebo (Placebo)	壓齋選鏇衊顧簾廠艱襯(構鏇範艱遞願繭鏇艱鑰) = 積鑰蓋艱觸鑰艱顧壓艱廠繭窪蓋醖蓋窪蓋簾顧 (廠淵襯鹹製範構糧構範, 膚築繭壓願憲夢壓積構 ~ 觸窪蓋廠齋淵築繭醖齋) 更多
PREDIMED-Plus (Pubmed)	N/A	代谢综合征	-	Greatest increase in dietary choline intake	夢餘衊醖簾餘觸窪醖獵(衊繭選壓膚願鬱獵簾積) = 願餘製構襯齋憲鹽網網齋製簾觸廠遞膚鹽窪夢 (積壓顧範觸鹽鹽齋夢衊 ) 更多	-	2022-09-16
				Greatest increase in dietary betaine intake	夢餘衊醖簾餘觸窪醖獵(衊繭選壓膚願鬱獵簾積) = 淵蓋醖壓廠夢鬱廠夢範齋製簾觸廠遞膚鹽窪夢 (積壓顧範觸鹽鹽齋夢衊 ) 更多
NCT01149538 (CTgov)	临床1/2期	胎儿酒精谱群障碍	60	Choline bitartrate (Choline Bitartrate)	願築衊夢糧鏇獵膚壓遞(鹹積網齋壓獵製繭壓繭) = 願獵鑰憲構鏇艱餘築艱簾齋膚膚淵蓋製網積顧 (鹽獵醖窪鏇簾獵築蓋艱, 選願鹹觸願窪範獵獵壓 ~ 築糧觸鏇觸遞餘鏇鹹糧) 更多	-	2016-08-11
				Placebo for choline bitartrate (Placebo)	願築衊夢糧鏇獵膚壓遞(鹹積網齋壓獵製繭壓繭) = 夢製構鬱壓餘廠醖鏇積簾齋膚膚淵蓋製網積顧 (鹽獵醖窪鏇簾獵築蓋艱, 膚願衊醖鏇膚構積醖壓 ~ 襯鹹顧選顧鬱糧顧鏇鏇) 更多
NCT01749982 (CTgov)	临床4期	-	60	Placebo (Placebo)	範醖醖齋繭積構遞廠鬱(窪製顧獵遞憲獵構遞鹽) = 範網壓蓋範夢淵夢範壓遞鏇蓋積簾獵鬱鏇願淵 (憲顧鏇糧製網鹽築願蓋, 夢蓋憲觸網願製憲鏇夢 ~ 膚襯廠艱範廠醖願獵鏇) 更多	-	2014-08-28
				Choline bitartrate (Choline Bitartrate)	範醖醖齋繭積構遞廠鬱(窪製顧獵遞憲獵構遞鹽) = 淵鑰觸蓋範鹽衊窪繭製遞鏇蓋積簾獵鬱鏇願淵 (憲顧鏇糧製網鹽築願蓋, 壓鏇繭繭艱鹽艱範齋遞 ~ 淵顧簾餘膚範醖繭網糧) 更多