BACKGROUND:
Iron deficiency limits the neurodevelopmental potential of more than 200 million children each year. Iron therapy is typically started when iron deficiency anemia is first diagnosed after screening for anemia or detection of clinical symptoms of iron deficiency anemia at 12 months of age. But iron started at this time does not fully correct earlier iron-deficiency-mediated brain dysfunction, underscoring the need for low-cost, easily implementable adjunct therapies to iron to treat or prevent this dysfunction in high-risk populations.
GAP Supplementation with the nutrient choline lessens damage to the hippocampus from early-life iron deficiency in pre-clinical models and improves hippocampus-mediated memory in children with Fetal Alcohol Spectrum Disorders. Choline has not been tested in children with iron deficiency anemia, despite strong pre-clinical and clinical evidence supporting a benefit to brain development.
HYPOTHESIS:
Infants with iron deficiency anemia who receive iron and nine months of daily choline supplements will have better scores on specific neurobehavioral tests of recognition memory than infants who receive iron and placebo.
METHODS:
This randomized, double-blinded, placebo-controlled clinical trial will randomize 300 6-month-old infants with iron deficiency anemia at Mulago Hospital, Kampala, Uganda, to iron plus choline or iron plus placebo to test the effect of choline on hippocampus-specific and global neurobehavioral outcomes after nine months.
RESULTS: Pending
IMPACT:
If our hypothesis is correct, choline could be added immediately to standard-of-care treatment for iron deficiency anemia. This intervention could safely mitigate the brain dysfunction of early-life iron deficiency that is often undiagnosed until the hippocampal critical window is closing. This simple, low-cost nutrient could thus have life-long benefit for both individuals and the economic and social prosperity of entire regions.

开始日期2024-12-02

申办/合作机构

University of Minnesota

PACTR202310844349932 / SuspendedN/AIIT

Acceptability of Super Cereal Plus with added choline in Malawian children

开始日期2023-10-31

申办/合作机构

Washington University in St. Louis

PACTR202310496960868 / SuspendedN/AIIT

Acceptability of a ready-to-use therapeutic food with added choline in Malawian children

开始日期2023-10-30

申办/合作机构

Washington University in St. Louis

100 项与重酒石酸胆碱相关的临床结果

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100 项与重酒石酸胆碱相关的转化医学

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100 项与重酒石酸胆碱相关的专利（医药）

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项与重酒石酸胆碱相关的文献（医药）

2024-09-01·TALANTA

A stability-indicating HPLC assay of ten different vitamins in a food supplement: Appraisal of the method's greenness, whiteness, and blueness

Article

作者: Ayoub, Bassam M ; Tony, Rehab Moussa ; Gamal, Mohammed ; Darwish, Hany W ; Abd Elhalim, Lobna Mohammed ; Abdelfatah, Rehab M

Due to their susceptibility to degradation, vitamin levels in food formulations may differ from those found in the finished product. Vitamin levels can be impacted by processing and storage. In this work, the ingredients of Strong B50 ® film-coated tablets were estimated simultaneously using simple efficient stability indicating HPLC method. Strong B50 ® film-coated tablets contain thiamine (VB1), riboflavin (VB2), calcium pantothenate (VB5), pyridoxine (VB6), vitamin C (VC), folic acid (FA), biotin (BT), inositol (IS), niacin (NC), para-aminobenzoic acid (PB), cyanocobalamine (B12), choline bitartarate, and iron gluconate. Hypersil BDS C18 column was used for achieving reasonable separation. Mobile phases (A) and (B) were utilized, the mobile phase (A) consisted of 0.015 M Hexane sulfonic acid sodium salt + 0.1 % Triethylamine and orthophosphoric acid was used to adjust the pH to (2.9) while (B) system consisted of acetonitrile. Validation of the method was assessed using International Conference of Harmonization (ICH) parameters, where linearity, accuracy, selectivity, and robustness of the method were investigated. Correlations were above 0.99, accuracy results ranged from 97.6 to 102.8 % and limits for detection and quantitation (LOD and LOQ) values were determined for each vitamin in μg/mL except for FA and BT in ng/mL. LOD values were between 0.006 and 15.08 μg/mL while LOQ values ranged from 0.031 to 49.77 μg/mL. Stability studies were conducted under stressed conditions and degradation percentages were computed. Where, VB5, VB6, FA and PB, VC, and NC were the most degradable vitamins. Whiteness evaluation using the modern RGB 12 algorithm compared our method and the old reported one by Sasaki et al., 2020. The comparison favored our newly developed method in terms of analytical performance, practical applicability and greenness. Besides, AGREE and GAPI soft wares were used to assess the greenness of the method. It was clear that the results of colored pictograms confirm low hazardous impact and that the new method is greener with AGREE score of 0.66. Furthermore, the functionality and applicability of the novel HPLC approach were concluded via the Blue Applicability Grade Index (BAGI) tool with a final score of 82.5.

2024-03-01·Pharmacological research

Combining choline bitartrate and vitamin B12 ameliorates cognitive impairment in hypertensive elders with cognitive frailty

Letter

作者: Kansakar, Urna ; Santulli, Gaetano ; Trimarco, Bruno ; Izzo, Raffaele ; Trimarco, Valentina ; Mone, Pasquale

A review.Frailty is a worldwide increasing health problem leading to adverse outcomes such as cognitive impairment, particularly in older adults [1].Cognitive frailty (CF) is a relatively novel type of frailty that refers to a condition characterized by the simultaneous presence of phys. frailty and cognitive impairment, particularly in older adults [2].CF represents a state of heightened risk for adverse health outcomes, including disability, dementia, falls, hospitalization, and mortality, compared to individuals who have either phys. frailty or cognitive impairment alone.The study participants were recruited at the ASL (Local Health Au-thority of the Italian Ministry of Health) Avellino, Italy.Every patient or legally authorized representative signed a written informed consent.We performed this investigation following the ethical standards of the 2013 Declaration of Helsinki of the World Medical Association and in accordance with Good Clin. Practice guidelines.We obtained the approval by the Institutional Review Board of Napoli Centro.We evaluated global cognitive function at baseline and after 3 mo using the MoCA test. MoCA scores range from zero to 30; a score of 26 and higher is considered normal.All patients fulfilled the following criteria: confirmed diagnosis of hypertension and CF; age >65 years; no previous stroke and/or acute myocardial infarction, no coronary artery bypass grafting, EF >50%; Montreal Cognitive Assessment (MoCA) Score <26.

2024-01-01·Semergen

Review

作者: Heras-Sola, J ; Gallo-Vallejo, J L

Pregnancy is one of the most important and difficult moments that a woman goes through throughout her life. It is a period of great need for macro and micronutrients to meet the demands of the developing fetus and avoid deficiencies, in order to obtain the best possible result. Nowadays, most women who are pregnant or planning to become pregnant know the importance of getting the required amount of certain types of nutrients (proteins, fats, folate, etc.), as well as avoiding certain compounds (alcohol, tobacco, drugs, etc.) to avoid possible complications during pregnancy. In recent years, with the greatest scientific evidence available, it has been shown how some of these nutrients could have a more relevant role than previously believed in the optimal outcome of pregnancy. One of these nutrients being choline. Choline supplementation during pregnancy has been shown to be a non-pharmacological treatment capable of improving both physical (growth) and mental (memory) qualities of the new individual. Choline has been known as an essential nutrient since 1998 and several studies have shown its effectiveness in rodent models. The existence of recent publications that deal with its application in humans makes it necessary to carry out a systematic review. In this systematic review of the scientific evidence available from 2012 to the present that deals with the application of a higher intake of choline through supplementation as a treatment to improve pregnancy outcomes, its main objetive is to determine the effects that a nutritional intervention through choline supplementation in pregnant mothers can have on children's cognition. For this, 9studies have been analyzed where the treatment given to pregnant women is revealed, this being choline supplementation in different modalities (choline chloride, choline bitartrate, and phosphatidylcholine) and the different effects produced in the children of these mothers who have resulted from these treatment modalities. We conclude by stating that choline supplementation during pregnancy appears to be effective in improving or increasing cognition in children.

项与重酒石酸胆碱相关的新闻（医药）

2024-08-26

·CPHI制药在线

会议报名 | 东南亚医药市场开拓机遇与挑战主题会议

✦ ✦ ✦ 随着中国经济的快速增长和科技实力的提升，国内新药研发蓬勃发展，为出海打下良好基础。一直以来，中国医药、原料药出口贸易在东南亚市场占有举足轻重的份额。其中，印度尼西亚、泰国、越南、菲律宾和马来西亚五个国家占据了东南亚医药市场的90%以上。未来这些国家将会成为国内企业转战的重要市场，包括投资建厂等深度合作开发。为助力中国药企加速布局东南亚医药市场，9月11日，东南亚医药市场开拓机遇与挑战主题会议将于CPHI & PMEC 制药工业展（深圳）展会期间在深圳会展中心（福田）举办。会议将从当下市场的最新国际形势出发，结合案例与报告，与上下游企业共同探讨东南亚市场的发展机遇。 ✦ ✦ ✦ 东南亚医药市场开拓机遇与挑战主题会议会议时间 9月11日会议地点深圳会展中心（福田）论坛区A（展位：9A56）主办单位上海博华国际展览有限公司承办单位北京东方比特科技有限公司协办单位 E药经理人扫描太阳码 0元领票并报名听会 8月30日前完成预登记现场可领取电子会刊一份 SHENZHEN 会议议程 09:30 主持人致辞 09:40-10:20 东南亚国家医药国际贸易报告嘉宾介绍吴惠芳北京东方比特（健康网）总经理兼首席研究员，北京玉德未来控股有限公司副总裁吴女士在军事医学科学院药物分析专业获理学硕士学位，1980年起从事药学相关工作，2000年前在部队医疗、科研机构从事临床药学、科研管理等工作，技术职务副主任药师。2000年退役后从事医药信息研究工作，专注于医药行业研究、市场研究、产业链结构研究等领域。在医药原料药、医药商品进出口、医药产业数据等信息方面有发布了大量文献资料和报告发表。为国内外企业、政府和科研机构提供咨询服务。连续多年为“中国化学制药工业协会”所著《医药发展蓝皮书》、《中国医药手册》作者之一；是《中国医药报》、《医药经济报》的特约撰稿人，在国内重要医药报刊发表大量文章。多次被邀请在中国医药行业大型会议和展览上做有关中国医药市场专题演讲。她的演讲以实际数据和案例阐明问题、总结变化规律，在中国制药企业中广为流传，受到医药界的好评。 ☝🏿☝🏿上下滑动了解嘉宾完整简介 10:20-10:50 中国制药企业出海东南亚国家的案例分享嘉宾介绍王亚锋上海医药国际业务事业部东南亚区域负责人、上药泰国总经理中国药科大学本科，中欧国际工商学院Global EMBA。从事医药国际营销工作十余年，深厚的医药行业知识和专业能力。拥有丰富的海外子公司运营和营销团队管理经验。深度参与海外工厂立项，写字楼，仓库等绿地项目建设。海外常驻包括非洲加纳，尼日利亚，乌干达，科特迪瓦，东南亚泰国，菲律宾等多个国家。熟悉多个市场药政法规以及行业准入要求。多次在海外国家从零开始设立全资公司、合资公司，组建销售团队，实现业绩从零突破，运作药品进入国家用药指南和国家医保。所在团队曾实现单品种中国制剂出口第一。历任复星医药集团桂林南药国际商务代表，销售经理，海外国家经理，大区经理等，现任上海医药国际业务事业部东南亚区域负责人，上药泰国总经理。 ☝🏿☝🏿上下滑动了解嘉宾完整简介 10:50-11:20 印度尼西亚制药业的机遇和市场开拓实践嘉宾介绍张君丽成都市一诺医药化工有限公司总经理采购总监公司团队深耕印尼市场十年，专注医药API等产品出口；聘请多名印尼本地员工，长期穿梭在印尼各个制剂工厂，拜访客户，与当地前十大药企均有超级深度的合作与链接！ 11:20-11:45 印尼清真医药产品市场情况更新嘉宾介绍 Dr. Ir. Muslich, M.Si Halal Partnership and Audit Services Director, LPPOM 获得IPB大学学士(S1)、研究生(S2)和博士(S3)学位;此前曾在多家私营公司工作(1991年至1993年)，PT TELKOM WITEL IX Jayapura农业和农用工业发展中心经理(1993年至1994年)，LPPOM MUI清真保证体系负责人(2010年至2015年)，QA和LPPOM MUI标准负责人(2015年至2019年)，LPPOM MUI高级顾问(2020年)，MUI清真认证要求开发团队负责人(2010年至2011年);现为IPB大学农业技术学院农业工业工程系讲师(自1994年起)，清真审核员(自1995年起)，清真管理体系标准制定技术委员会(SNI 99 001)成员，清真家禽屠宰场(SNI 99 002)，家庭切清真反刍(SNI 99 003)，清真食品(SNI 99 004)国家标准化机构(自2015年起)，SKKNI主管能力测试设备开发团队负责人Halal & SKKNI清真审核员(自2017年起)，国家认证机构能力评估员职业(BNSP)(自2015年起)，食品安全能力评估员，机构专业认证(LSP)食品质量保证与安全(JMKP)(自2015年起);于2020-2022年被任命为LPPOM MUI清真合作与审计服务总监。 ☝🏿☝🏿上下滑动了解嘉宾完整简介 11:20-12:00 圆桌讨论：寻找东南亚市场的机会讨论嘉宾深圳市远邦医药有限公司湖南尔康制药股份有限公司成都倍特药业有限公司广州康臣药业有限公司 ...... 扫描太阳码 0元领票并报名听会 8月30日前完成预登记现场可领取电子会刊一份把握东南亚市场发展机遇加速融入全球制药供应链随着东南亚医药市场的发展潜能进一步释放，中国医药企业将迎来更多发展机遇。作为中国药企链接国际市场的重要纽带，CPHI & PMEC 制药工业展（深圳）将携手400余家优质展商，共同探索企业在东南亚乃至全球市场的发展路径。下面就请跟随小编的步伐，一起走近本期的优选展商吧！浙江瑞邦药业股份有限公司展位：9F08 浙江瑞邦药业股份有限公司成立于1956年，具有60多年生产医药原料药和食品添加剂的生产经验。公司以药品生产质量管理规范（GMP) 标准组织生产和销售。本公司的产品获得了美国FDA，欧洲CEP和中国GMP的认证。主要产品有葡萄糖酸盐系列，莫匹罗星，莫匹罗星钙，环孢菌素，夫西地酸等。浙江瑞邦药业股份有限公司在国内外都享有良好的声誉。产品远销美国，欧洲，日本，印度及其他南美和东南亚地区。主推产品环孢菌素、莫匹罗星、莫匹罗星钙、葡萄糖酸钙、葡萄糖酸锌、葡萄糖酸钾、葡萄糖酸镁、葡萄糖酸亚铁、葡萄糖酸铜、葡萄糖酸锰、葡萄糖酸钠、多粘菌素B、夫西地酸、夫西地酸钠、米尔贝肟、葡萄糖酸内酯、非达霉素、甘草次酸、原儿茶酸。 ☝🏿☝🏿上下滑动查看完整展商介绍河北华晨药业集团有限公司展位：9D46 河北华晨药业集团有限公司，始建于1991年，坐落于黄骅经济开发区。是一家集研发、生产、销售药用包装材料、原料药、制剂、医疗器械，开展国内外贸易为一体的医药企业。集团公司现下设河北华晨药业有限公司、黄骅华宾生物科技有限公司、河北华迪药业有限公司、华晨吉海（北京）药物研究院。目前华晨药业拥有通过GMP认证的药用氯化钠、碳酸氢钠、氯化钾及新增制剂包括片剂、硬胶囊制剂、颗粒剂、散剂、软膏剂、凝胶贴膏剂、口服液等数十种，同时生产药用PE袋、膜、包装桶、瓶等药用包装材料等。主推产品氯化钠、碳酸氢钠、氯化钾、氯化钙、氯化铵、依地酸二钠、重酒石酸胆碱、富马酸（辅料、富马酸亚铁、醋酸钙、醋酸钠、硫酸镁、碘化钾、氯化镁、富马酸亚铁、葡萄糖酸锌、葡萄糖二酸钙、双乙酸钠、树脂再生剂、碳酸镧、硫酸钾、利多卡因、氟比洛芬、氯化镁、麝香草粉、盐酸利多卡因、葡萄糖酸钙、洛索洛芬钠、磷酸奥司他韦、无水硫酸钠、氨苯蝶啶、托匹司特、硫酸亚铁、西甲硅油、硫酸双肼屈嗪、甘羟鋁、葡萄糖酸亚铁、叔丁醇镁、异丙醇镁、二甲硅油、碳酸钙、亚硫酸镁（六水）、硫酸钾、乳酸钙、乳酸钠、乳果糖、丙胺卡因、喷托维林、丁卡因、双氯芬酸依泊胺、克立硼罗、阿达帕林、盐酸异丙嗪、高岭土、克罗米通、盐酸异丙嗪、氨苯蝶啶、叔丁醇镁、异丙醇镁、亚硫酸镁知名。 ☝🏿☝🏿上下滑动查看完整展商介绍山西阳和药业有限公司展位号：9A13 山西阳和药业有限公司成立于2017年，坐落于山西省大同市阳高县龙泉工业园区。公司注册资本5100万元，总占地面积100亩。阳和药业作为化学原料药的商业化生产基地，专业从事特色化学原料药的研发、生产、销售。公司现拥有多条原料药生产线，产品涉及呼吸系统、消化系统等多个领域。目前公司可大批量生产乙酰半胱氨酸、间苯三酚、间苯三酚三甲醚、聚乙烯醇等原料药。主推产品乙酰半胱氨酸、间苯三酚、聚乙烯醇、间苯三酚三甲醚。 ☝🏿☝🏿上下滑动查看完整展商介绍浙江荣耀生物科技股份有限公司展位：9C51 浙江荣耀生物科技股份有限公司创立于1999年，位于台州湾经济技术开发区，是一家集研发、生产、销售于一体的创新型医药企业，是国家高新技术企业、浙江省专精特新中小企业、浙江省科技型中小企业。业务涵盖医药原料药及中间体、兽药原料药及中间体、CDMO等。主推产品二硝托胺148-01-6、甲砜霉素15318-45-3、氟苯尼考73231-34-2、非班太尔58306-30-2、芬苯达唑43210-67-9、莫昔克丁113507-06-5、赛拉菌素220119-17-5、氟雷拉纳864731-61-3、奥拉替尼1208319-26-9、2-氨基-N-(2、2、2-三氟乙基)乙酰胺盐酸盐1171331-39-7、三氯苯达唑68786-66-3、癸氧喹酯18507-89-6、尼卡巴嗪330-95-0、3′、5′-二氯-2、2、2-三氟苯乙酮130336-16-2、4-氯吡咯并嘧啶3680-69-1、反式-N-甲基-[4-(甲氨基)环己基]甲磺酰胺1809995-95-6、依帕司他82159-09-9、盐酸氨溴索23828-92-4、盐酸金刚乙胺1501-84-4、盐酸溴己新611-75-6、西司他丁82009-34-5、3-甲基-6-硝基-1H-吲唑6494-19-5、2-[4-(2-吡啶基)苄基]-肼羧酸叔丁酯198904-85-7、2-氨基-1-(2、5-二甲氧基苯基)乙醇3600-87-1、3-(三氟甲基)-5、6、7、8-四氢-[1、2、4]三唑并[4、3-a]吡嗪盐酸盐762240-92-6、(3S、4R)-4-(4-氟苯基)-1-甲基-3-哌啶甲醇105812-81-5、1-(4-氨基苯基)环戊甲腈115279-73-7、3-氨基-1-金刚烷醇702-82-9、1-金刚烷甲酸828-51-3、2-金刚烷酮700-58-3、1-金刚烷胺768-94-5、1-金刚烷甲醇770-71-8、2-金刚烷醇700-57-2、1-金刚烷醇768-95-6。 ☝🏿☝🏿上下滑动查看完整展商介绍江苏宇田医药有限公司展位：9E31 江苏宇田医药有限公司是一家从事现代医药研发、生产、销售为一体的新型特色API及CDMO制药企业，致力于为国内各大制药企业提供高质量的原料药与中间体，公司产品同时远销欧洲、日韩、印度等数十个国家，为国家重点高新技术企业、市科技小巨人企业、中华药港新医药产业基地骨干企业之一。宇田医药始终把科研开发作为企业可持续发展的支撑力量，是国内科研投入较多的药企之一，公司以连云港研发中心为科研载体，配合杭州科巢生物科技、连云港万科生物科技、黑龙江迪诺医药，自主创新能力不断增强。形成了“以一带三”的良性格局。宇田医药在江苏连云港、黑龙江佳木斯建有两个生产基地，获得国家高新技术企业、省级工程技术研究中心、江苏省瞪羚企业、江苏省科技型中小企业、安全标准化二级企业、省两化融合示范试点企业，同时也获得了原料药品种的GMP和注册现场核查的二合一认证，先后承担省/市级成果转换等多个省/市级科技项目；获得授权专利与商标数十项；通过ISO9000、ISO14000认证。这些荣誉的取得标志着企业药品生产质量和管理水平走在了全国医药行业前列。主推产品原料药：碘克沙醇、碘海醇、阿托伐他汀钙、瑞舒伐他汀钙、盐酸伊伐布雷定、利奈唑胺、西洛多辛、盐酸厄洛替尼、盐酸莫西沙星及各中间体。中间体：造影剂系列中间体、多尼培南侧链、比阿培南侧链、1,4-丁二磺酸。 ☝🏿☝🏿上下滑动查看完整展商介绍江苏同禾药业有限公司展位：9D26 江苏同禾药业有限公司是江苏万兴创业投资有限公司的全资子公司，是一家集制剂药、原料药和保健食品的研发、生产、销售为一体的国家高新技术企业。连续8年，跻身于常熟市百强企业前50 名。公司拥有原料药、片剂、胶囊剂和颗粒剂的GMP证书。硫辛酸、6.8-二氯辛酸乙酯、右旋硫辛酸钠、环丙贝特、10-甲氧基亚氨基芪等多个产品被评为江苏省高新技术产品；硫辛酸、盐酸二甲双胍等取得了原料药品批件，厄多司坦片、氨酚伪麻分散片和新雪胶囊等取得药品注册批件和新药证书；硫辛酸片和胶囊即将取得新药证书，另有10多个新药正在SFDA审批中。调节血糖和控制并发症的保健食品唐苹片正在全国热销中。主推产品硫辛酸系列、右旋硫辛酸、右旋硫辛酸钠盐、右旋硫辛酸氨基丁三醇盐。 ☝🏿☝🏿上下滑动查看完整展商介绍 CPHI & PMEC 制药工业展（深圳）致力于打造国际化制药产业生态圈，汇集产业链上下游实力企业，以技术驱动产业提升，助推更多中国药企扬帆“出海”，聚势共赢！扫描二维码 0元领票 8月30日前完成预登记现场可领取电子会刊一份金秋九月·不见不散！联系我们参观咨询林女士电话：021-33392105 邮箱：ashley.lin@imsinoexpo.com 张女士电话：010-58036315 邮箱：zhangyuanyuan@cccmhpie.org.cn 参展咨询茅女士电话：021-33392250 邮箱：chris.mao@imsinoexpo.com 吴女士电话：010-58036296 邮箱：wuyushuang@cccmhpie.org.cn 👇点击“阅读原文”，免费领取展会参观门票！！

高管变更

2024-03-21

·PRNewswire

GO BEYOND HEALTHY HYDRATION WITH SALTHEAD™ - AVAILABLE AT NUTRISHOP

New advanced electrolyte formula appeals to those looking to fuel their body and mind HENDERSON, Nev., March 21, 2024 /PRNewswire/ -- NUTRISHOP® continues to lead the way in nutritional supplement innovation with its latest offering from Xcelerated Performance Products® (XP2): SALTHEAD™. This product's advanced formula goes beyond standard electrolyte replenishment with its inclusion of 100% Pink Himalayan Salt, 72 trace minerals, and a generous dose of the brain-boosting nootropic Choline Bitartrate. In a world where dehydration often goes unnoticed, SALTHEAD emerges as a smart solution for your body and mind. Continue Reading "SALTHEAD bridges the gap between healthy hydration and overall vitality," Bryon McLendon, founder and CEO of Nutrishop. Post this Redefine your hydration and health routine with& SALTHEAD,& available exclusively at& Nutrishop locations nationwide& and& NutrishopUSA.com. You see, hydration is not just about water—it's about mineralization. Merely having water in your body doesn't guarantee hydration; it's about ensuring that the water reaches your tissues. This is where electrolytes come into play. However, not all electrolyte formulas are created equal. "SALTHEAD bridges the gap between healthy hydration and overall vitality and is a testament to our commitment to innovation, quality, and the well-being of our customers," said Bryon McLendon, Nutrishop's founder and CEO. "This product is not just for athletes or fitness enthusiasts, it's for anyone looking to improve their health and wellness game." Christina Hubacek, a dedicated firefighter from Mesquite, TX, praises SALTHEAD's effectiveness: "It's definitely a game-changer for me and has become an important part of my daily routine, ensuring I stay hydrated and energized." Why Choose SALTHEAD? Next-Level Hydration: As an electrolyte formula, SALTHEAD goes beyond water alone. "A lot of people think that just drinking water equals hydration. But, it's the electrolytes that matter—they're the real MVPs, making sure the water you drink actually does its job hydrating your cells properly," explained Jay Vicino, franchisee of the Mt. Juliet Nutrishop store in Tennessee. Unmatched Formula: Each serving of SALTHEAD contains 1,000mg of 100% Pink Himalayan Salt, which circumvents the potentially harmful effects of microplastics that may be found in some of the other forms of salt in circulation today. SALTHEAD also includes 1.5g of Choline Bitartrate (yielding 600mg of choline) and 72 Ionic Trace Minerals, which support internal bodily processes while contributing to overall health. Mental-Edge Boost: Choline is a highly sought-after ingredient known for supporting cognitive function. "Choline is essential for our everyday lives, but most people don't consume an adequate amount through whole foods or supplementation," Vicino, who is ISSA-certified in fitness nutrition, said. "SALTHEAD helps ensure you are getting enough Choline and then some!" No Unnecessary Additives: Unlike some electrolyte formulas available today, SALTHEAD contains no artificial sweeteners or synthetic colors, prioritizing health above all. Taste Matters: Available in Salty Watermelon and Salty Raspberry flavors, SALTHEAD provides a refreshingly tasty way to stay hydrated, healthy, and replenished. Look for a new flavor to come out later this year! "I love SALTHEAD because I can actually feel it working, which is something I haven't had with other products I've tried," said Ayme Salas, of Nashville, TN. "And it tastes great, too!" Get SALTHEAD today! Ready to redefine your hydration and health routine? SALTHEAD is available exclusively at Nutrishop locations nationwide and can be conveniently purchased online at NutrishopUSA.com. Remember, it's not just about drinking fluids; it's about ensuring your body is fully nourished, hydrated, and ready to perform at its best – no matter what your day brings. About Xcelerated Performance Products® (XP2): Xcelerated Performance Products® (XP2) is at the forefront of nutritional science, developing high-quality supplements that empower individuals to achieve optimal health and performance. With a relentless commitment to innovation, XP2 continues to introduce products that set new standards in the supplement industry. About NUTRISHOP® Since 2003, Nutrishop has helped countless individuals live a fit, healthy, happy lifestyle. Nutrishop stores offer customers a low-price guarantee on a wide array of cutting-edge dietary supplements, exceptional, individualized customer service, easy-to-follow meal plans, body composition assessment tools, and sound nutritional guidance. The Nutrishop business model focuses primarily on franchisee-owned and operated stores that provide consumers with the tools to achieve their health and fitness goals. For more information, visit NutrishopUSA.com and follow on Instagram @NutrishopUSA. To learn more about becoming a Nutrishop franchisee, visit NutrishopFranchise.com. SOURCE Nutrishop

2023-06-29

·PRNewswire

Oomph Body's Natural Sleep Aids Beat Pharmaceutical Alternatives

The Health Brand's Innovative Nutraceutical Medical Foods Offer Sweet, Safe Relief From Sleep Deprivation FORT LAUDERDALE, Fla., June 29, 2023 /PRNewswire/ -- Insomnia is a common struggle. As much as 33% of adults struggle with significant sleep deprivation, while one in 10 adults is considered to have chronic insomnia as a medical condition. Many individuals resort to strong chemical prescriptions to address their stressed-out sleep. But Sleep Foundation reports nearly twenty different potential side effects that come from taking sleep medications, including nausea, dizziness, and even uncontrollable shaking. Mayo Clinic also lists 11 different kinds of chemically-based sleep meds that either help you fall asleep or stay asleep — nearly all of which can develop dependencies. This struggle between insomnia and the side effects of sleep medications is what led the health and wellness brand Oomph Body to develop its Lights Out and Deep Sleep aminos products. Both dietary supplements use natural ingredients like GABA and Choline Bitartrate to help improve quality of sleep and parasympathetic nervous system function, respectively, leading to a better night's sleep. "We created Oomph Body because simply trying to 'be healthy' isn't enough," says company co-founder and CEO Scott Sharp. "We wanted to help people reach their fullest potential. That's why our go-to saying is that we help you 'Thrive at the Speed of Life.'" Sharp is a retired professional racecar driver that has spent his life pursuing health and wellness at top speeds. The CEO goes on to add that while thriving often means maximizing energy and output, sometimes it has to do with optimizing recovery, too. "Our sleep aid range is designed to help you rest and recharge — like, really rest and recharge. They're a medical food that ensures you aren't wasting your downtime. Clinically-proven medical food is slightly different from traditional vitamins. It is a distinct category of FDA-regulated products that helps with the specific and unique requirements of those managing a chronic disease. They use science and clinical research to focus on supporting and addressing underlying metabolic changes. "When we went to market our Deep Sleep and Lights Out aminos products," explains Sharp's co-founder and Oomph Body president, Dan Austin, "we wanted to test them to see how they held up against the stronger chemical alternatives — you know, the stuff like Zolpidem, which is used in Ambien. We wanted to see how our natural food-based formulations measured up against the kind of insomnia drugs that people don't want to become overly reliant on. Our medical foods went head-to-head against Ambien and won." As is the case with all of Oomph Body's supplements, Deep Sleep and Lights Out offer the brand's customers a clean, natural alternative to harmful pharmaceutical-grade products. They offer a drug-free, non-addictive way to safely address the struggle to sleep. And yet, they don't require a compromise with potency. A rarity in the nutraceutical world, Oomph Body's sleep-focused medical foods provide consumers with a way to safely get a great night's sleep with no side effects. "If you want to thrive," says Sharp, "You need your rest. Our products deliver on that need without risking other areas of your health in the process." About Oomph Body Oomph Body is a nutraceutical developer and manufacturer that is owned by professional race car driver Scott Sharp and tech and wellness industries alumni Dan Austin. Together, the dynamic duo is blazing a new trail for nutraceuticals by developing groundbreaking formulas that combine innovative, synergistic ingredient blends to create effective results in those looking to care for their minds and bodies. All Oomph Body products are formulated and manufactured in the U.S. Learn more at oomphbody.com. Contact: Scott Sharp 561-914-1888 [email protected] SOURCE Oomph Body

100 项与重酒石酸胆碱相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
铁缺乏	临床3期	-	University of Minnesota	2024-12-02
胎儿酒精谱群障碍	临床2期	美国	University of Minnesota	2016-06-01
阿尔茨海默症	临床1期	美国	University of Texas Health Science Center at Houston	2023-06-26

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02735473 (CTgov)	临床2期	胎儿酒精谱群障碍	46	Choline bitartrate (Choline Bitartrate)	壓築鏇遞鏇築積壓網蓋(艱積鹹餘憲範願簾網顧) = 鹽遞網廠製選醖壓艱鑰膚憲簾壓鑰獵網鑰鑰夢 (鹹鑰鹽糧選鬱範遞醖範, 繭願窪膚鑰廠憲夢簾選 ~ 窪選艱壓艱膚壓襯鬱遞) 更多	-	2022-11-01
				Placebo (Placebo)	壓築鏇遞鏇築積壓網蓋(艱積鹹餘憲範願簾網顧) = 齋簾鹹繭廠遞鹹蓋鏇觸膚憲簾壓鑰獵網鑰鑰夢 (鹹鑰鹽糧選鬱範遞醖範, 獵衊窪蓋製願鬱蓋鏇範 ~ 願繭簾襯簾觸願餘遞範) 更多
PREDIMED-Plus (Pubmed)	N/A	代谢综合征	-	Greatest increase in dietary choline intake	襯觸選築範鏇壓遞鏇範(窪製醖衊餘鬱顧壓繭夢) = 觸鑰積窪鏇願夢製襯簾壓膚製鏇鬱選遞壓淵鑰 (齋顧觸窪遞糧顧鹹簾鏇 ) 更多	-	2022-09-16
				Greatest increase in dietary betaine intake	襯觸選築範鏇壓遞鏇範(窪製醖衊餘鬱顧壓繭夢) = 廠齋鬱襯廠餘顧構網餘壓膚製鏇鬱選遞壓淵鑰 (齋顧觸窪遞糧顧鹹簾鏇 ) 更多
NCT01149538 (CTgov)	临床1/2期	胎儿酒精谱群障碍	60	Choline bitartrate (Choline Bitartrate)	獵窪廠獵餘獵繭願艱簾(積糧繭餘糧淵淵糧觸艱) = 製製鹽範積鏇築觸鹹廠鹽襯網選觸襯醖築齋淵 (齋獵觸糧獵壓膚顧壓淵, 鬱鏇觸廠糧夢鹽遞築膚 ~ 衊鏇齋選衊齋遞廠醖淵) 更多	-	2016-08-11
				Placebo for choline bitartrate (Placebo)	獵窪廠獵餘獵繭願艱簾(積糧繭餘糧淵淵糧觸艱) = 淵夢積夢衊夢蓋鑰齋壓鹽襯網選觸襯醖築齋淵 (齋獵觸糧獵壓膚顧壓淵, 遞艱積鏇築鑰築糧齋醖 ~ 壓壓壓膚衊襯積憲齋憲) 更多
NCT01749982 (CABS, CTgov)	临床4期	-	60	Placebo (Placebo)	艱壓選繭顧廠鏇簾淵選(醖獵夢鹹餘淵醖窪廠願) = 獵積網網網顧膚顧顧網廠觸繭遞鑰蓋鹽網蓋衊 (襯窪夢憲觸製遞觸襯鏇, 築簾窪衊鬱網膚糧醖顧 ~ 構蓋醖遞範淵廠廠醖壓) 更多	-	2014-08-28
				Choline bitartrate (Choline Bitartrate)	艱壓選繭顧廠鏇簾淵選(醖獵夢鹹餘淵醖窪廠願) = 築衊艱齋齋艱襯蓋鹽選廠觸繭遞鑰蓋鹽網蓋衊 (襯窪夢憲觸製遞觸襯鏇, 顧願獵蓋糧窪鏇鹽選襯 ~ 鬱夢鬱選窪膚獵衊網鬱) 更多