更新于：2024-11-13
T-101
治疗用乙型肝炎腺病毒(Transgene)
更新于：2024-11-13
概要
基本信息
原研机构 |
非在研机构- |
最高研发阶段临床2期 |
首次获批日期- |
最高研发阶段(中国)临床2期 |
特殊审评- |
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关联
5
项与 治疗用乙型肝炎腺病毒(Transgene) 相关的临床试验A Phase II Clinical Trial to Evaluate the Safety and Efficacy of Therapeutic Hepatitis B Adenovirus Injection (T101) Combined With Nucleoside (Acid) Analogues in Chronic Hepatitis B Patients
T101联合核苷（酸）类似物治疗慢性乙型肝炎患者的安全性和有效性的II期临床试验
评价T101在慢性乙肝患者中随机、双盲、安慰剂对照的多剂量、单次、多次给药的耐受性、初步药效学I期临床试验
100 项与 治疗用乙型肝炎腺病毒(Transgene) 相关的临床结果
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100 项与 治疗用乙型肝炎腺病毒(Transgene) 相关的转化医学
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100 项与 治疗用乙型肝炎腺病毒(Transgene) 相关的专利（医药）
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89
项与 治疗用乙型肝炎腺病毒(Transgene) 相关的文献（医药）2018-12-01Virology journal3区 · 医学
Correction to: Immunogenicity of adenovirus-vector vaccine targeting hepatitis B virus: non-clinical safety assessment in non-human primates
3区 · 医学
ArticleOA
作者: Zhao, Shuli ; Lu, Jing ; Wang, Jing ; Zhang, Xuefeng ; Li, Rongrong
Ad-HBV is a product (T101) aiming to treat chronic HBV firstly developed by Transgene S.A., France then by Transgene Tasly (Tianjin) Biopharmaceutical Co., Ltd., Tianjin, China in China.
2018-09-01Journal of cellular physiology2区 · 生物学
Transglutaminase activity regulates differentiation, migration and fusion of osteoclasts via affecting actin dynamics
2区 · 生物学
Article
作者: Kaartinen, Mari T. ; Sun, Huifang
Osteoclasts, bone resorbing cells, derive from monocyte/macrophage cell lineage. Increased osteoclast activity is responsible for bone destruction in diseases such as osteoporosis, periodontitis and rheumatoid arthritis. Transglutaminases (TGs), protein crosslinking enzymes, were recently found involved in osteoclastogenesis in vivo, however their mechanisms of action have remained unknown. In this study, we have investigated the role of TG activity in osteoclastogenesis in vitro using four TG inhibitors, NC9, Z006, T101, and monodansyl cadaverine. Our results showed that all TG inhibitors were capable of blocking the entire osteoclastogenesis process. The most potent of the inhibitors, NC9 when added to cultures at different phases of osteoclastogenesis, inhibited differentiation, migration, and fusion of pre‐osteoclasts as well as resorption activity of mature osteoclasts. Further investigation into the mechanisms revealed that NC9 increased RhoA levels and blocked podosome belt formation suggesting that TG activity regulates actin dynamics in pre‐osteoclasts. The inhibitory effect of NC9 on osteoclastogenesis as well as podosome belt formation was completely reversed with a Rho‐family inhibitor Exoenzyme C3. Microtubule architecture, acetylation, and detyrosination of α‐tubulin were not affected. Finally, we demonstrated that macrophages and osteoclasts expressed mRNA of three TGs:TG1, TG2, and Factor XIII‐A which were all differentially regulated in these cells during differentiation. Immunofluoresence microscopic analysis showed that all three enzymes co‐localized to podosomes in osteoclasts. Taken together, our data suggests that TG activity regulates differentiation, migration and fusion of osteoclasts via affecting actin dynamics and that this may involve contribution from all three TG enzymes.
2018-07-04Nutrition and cancer4区 · 医学
Transglutaminase 2 Mediates the Cytotoxicity of Resveratrol in a Human Cholangiocarcinoma and Gallbladder Cancer Cell Lines
4区 · 医学
Article
作者: Scricciolo, Alice ; Lombardo, Vincenza ; Tosi, Delfina ; Vaira, Valentina ; Braidotti, Paola ; Tacchini, Lorenza ; Roncoroni, Leda ; Branchi, Federica ; Doneda, Luisa ; Elli, Luca
Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Our aim was to evaluate if the cytotoxic effect of resveratrol (RES) on cholangiocarcinoma (CC) and gallbladder cancer (GBC) cell lines could be abolished by TG2 inhibition. Human CC and GBC cell lines (SK-ChA-1 and MZ-ChA-1), grown in a three-dimensional cell culture system (MCTS, multicellular tumor spheroids), were treated for 72 h with RES (32, 64 µM) alone or combined with different TG2 inhibitors (Cystamine, B003, T101). We investigated: cells viability; cell morphology with light microscopy (LM) and transmission electron microscopy (TEM); immunoreactivity with immunohistochemistry; Q-Banding karyotype analysis; TG2 activity; Western blotting. RES treatment induced a significant inhibition of cell growth, ranging from 24% to 76% in both cell lines. The inhibitors successfully reduced TG2 activity without any variation of protein quantity as demonstrated by immunohistochemistry and Western blot. TG2 inhibition resulted in cell growth normalization. In addition, morphologic analysis by light and transmission electron microscopy confirmed the cytotoxic effect of RES and its reduction consequent to TG2 inhibition. Our data demonstrated a connection between the cytotoxic effect of RES in SK-ChA-1 and MZ-ChA-1 and TG2 activity.
1
项与 治疗用乙型肝炎腺病毒(Transgene) 相关的新闻（医药）2023-05-15
·信狐药迅
100 项与 治疗用乙型肝炎腺病毒(Transgene) 相关的药物交易
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性乙型肝炎 | 临床2期 | 中国 | 2019-11-27 | |
| 乙型肝炎 | 临床2期 | - | - |
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