Aim:This study aimed to develop and evaluate lornoxicam (LXM) and thiocolchicoside
(TCS) transferosomal transdermal patches.Background:Oral administration of LXM and TCS can lead to gastric irritation, necessitating alternative
delivery methods for pain and inflammation relief. Incorporating LXM & TCS into transferosomes
within a transdermal patch offers a potential solution.Objective:The objective of this study is to develop and evaluate transferosomal transdermal patches
containing LXM and TCS, incorporating Aloe vera leaf mucilage (AVLM) and lime oil (LO) as
permeability enhancers. The aim is to enhance the skin permeation of these drugs while mitigating
gastric irritation associated with their oral administration.Method:Transferosomes were made by the thin film hydration tactic, with nine formulations based
on three independent variables: phosphatidylcholine, span 80, and sonication time. Entrapment efficiency
and drug release at 6th h were assessed as dependent variables. The optimized combination
was then formulated into transdermal patches via central composite design, evaluating the impact of
AVLM and LO on lornoxicam discharge and other physicochemical properties.Results:The average weight and thickness of the patches ranged from 7.52±0.75 to 8.07±0.11g and
from 1.69±0.01 to 1.82±0.02mm, respectively, representing minimal variance. The LXM/TCS content
homogeneity ranged from 92.84±3.55 to 94.07±4.61% for LXM and from 90.17±1.98 to
93.18±2.98% for TCS, demonstrating robust uniformity. Higher proportions of phosphatidylcholine
and span 80, along with lesser sonication time, led to improved entrapment of lornoxicam. In vitro,
discharge studies demonstrated optimal discharge with a higher proportion of phosphatidylcholine, a
medium proportion of span 80, and a longer sonication time. The transferosomal patches exhibited
zero-order discharge kinetics, with LXM & TCS discharge % at 24, 48, and 72 h.Conclusion:The study concludes that formulation TDP-8, which incorporates 3g of Aloe vera leaf
mucilage (AVLM) and lime oil (LO) as permeability enhancers, demonstrated favorable discharge
characteristics. This indicates its potential as an effective transdermal delivery system for LXM and
TCS, offering a promising substitute for pain and inflammation relief while minimizing gastric irritation.
The study succeeded in developing and evaluating transferosomal transdermal patches for
LXM and TCS, providing an alternative delivery method that minimizes gastric irritation.