预约演示

更新于：2025-05-07

2′,4′-Dimethoxychalcone

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

DTC

靶点-

作用方式-

作用机制-

治疗领域

感染其他疾病

在研适应症

细菌感染炎症

非在研适应症-

原研机构

Shandong University of Traditional Chinese Medicine

在研机构

Shandong University of Traditional Chinese Medicine

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)临床前

特殊审评-

结构/序列

分子式C17H16O3

InChIKeyZRDCNUALRUCCPA-UHFFFAOYSA-N

CAS号1154-77-4

关联

100 项与 2′,4′-Dimethoxychalcone 相关的临床结果

登录后查看更多信息

100 项与 2′,4′-Dimethoxychalcone 相关的转化医学

登录后查看更多信息

100 项与 2′,4′-Dimethoxychalcone 相关的专利（医药）

登录后查看更多信息

486

项与 2′,4′-Dimethoxychalcone 相关的文献（医药）

2025-04-21·ACS Applied Bio Materials

Near-Infrared Light-Controlled Nitric Oxide Delivery Combined with In Situ Activated Chemotherapy for Enhanced Multimodal Therapy

Article

作者: Fang, Jian ; Wang, Yi ; Yang, Shiping ; Liu, Jing ; Liu, Jin-Gang ; Tang, Qi ; Ren, Bing

Development of nanoplatforms with in situ activation for chemotherapy represents a promising modality for biomedical application. Herein, a multifunctional nanoplatform, CMS@DTC@PDA@RuNO@FA (abbreviated as CDPNF NPs), was developed for highly efficient antitumor therapy, in which diethyldithiocarbamate (DTC)-loaded mesoporous Cu₂MoS₄ (CMS) nanoparticles were covered by polydopamine (PDA) layers and further covalently modified with a NO donor (RuNO) and a folic acid (FA)-directing moiety. Under the mild acidic tumor microenvironment (TME), the CDPNF NPs co-liberated DTC and Cu²⁺ in the tumor site, where in situ formation of the highly cytotoxic Cu(DTC)₂ complex effectively killed tumor cells. Furthermore, under near-infrared (NIR) light irradiation, the CDPNF NPs could deliver nitric oxide (NO) and produce superoxide anions (O₂^•-), followed by the formation of more toxic peroxynitrite (ONOO^-), which led to promoted cell apoptosis. Under 1064 nm NIR light irradiation, in vivo experiments with CDPNF NPs demonstrated an impressively high tumor inhibition rate (∼97%) while with good biocompatibility. This work represents an in situ activated approach for precision medicine that might imply its promising potential for clinical applications.

2025-03-31·Autism : the international journal of research and practice

Pilot randomized controlled trial of MINDful TIME, a novel telehealth mindfulness-based intervention for autistic adolescents and their caregivers.

Article

作者: Boyd, Summer ; Blair Braden, B ; Matthews, Nicole L ; Malligo, Amanda ; Honda, Hannah ; Pagni, Broc A ; Mitchell, Melissa M

A growing body of research suggests that mindfulness-based interventions may be a valuable method for reducing internalizing symptoms in autistic individuals. The current study extends this work using an effectiveness-implementation hybrid type 1 study. In this parallel randomized controlled trial, we examined a novel telehealth intervention for autistic adolescents and their caregivers. MINDful TIME includes eight weekly group meetings and regular use of a commercially available mindfulness meditation app. Participants were 42 adolescent-parent dyads randomized to the treatment or delayed treatment control (DTC) group. The program was implemented with fidelity (91.24%-94.78%), and 90% of treatment group dyads completed the program. On average, participants attended >90% of sessions and reported high acceptability. Treatment group adolescents demonstrated statistically and clinically significant reductions in parent-reported depression symptoms relative to DTC (F(1, 34) = 7.31, p = 0.01, __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__ηp2 = 0.18). Female adolescents in the treatment group showed significant reductions in parent-reported anxiety symptoms (F(1, 34) = 4.22, p = 0.05, __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__ηp2 = 0.11). Exploratory analyses indicated treatment-related improvements in adolescent executive functioning, parent mindfulness and well-being, and adolescent-parent relationship dysfunction. Findings warrant future examination of MINDful TIME to address well-documented challenges with mental health in this population. This trial was registered on clinicaltrials.gov (NCT05685589).Lay abstractPrevious research studies have found that mindfulness (i.e. focused attention on, and acceptance of, the present moment) training programs can reduce stress, depression, and anxiety. However, more research is needed to understand whether mindfulness strategies are helpful for autistic teens. We examined a new telehealth intervention for autistic teens and their caregivers. MINDful TIME is an 8-week group program that meets weekly through Zoom meetings. Participants learn mindfulness strategies through didactic lessons and using a commercially available mindfulness meditation mobile app. We randomly assigned 42 teens (ages 13-18 years) with an autism diagnosis and their parents to complete MINDful TIME or an 8-week wait period before beginning the program. Ninety percent of teens and parents assigned to MINDful TIME completed the program and reported that they found the program to be acceptable. Teens who completed MINDful TIME showed large reductions in depression symptoms, whereas teens in the wait period group did not. Females who completed MINDful TIME also showed reductions in anxiety symptoms, whereas males who completed MINDful TIME and females and males in the wait period group did not. Parents who completed MINDful TIME with their teens showed increased mindfulness traits, well-being, and adolescent-parent relationship functioning. Findings suggest that MINDful TIME is a promising program that may improve accessibility of mindfulness strategies for autistic teens and their caregivers. Future research with a larger sample size is needed to fully understand the benefits of the program.

2025-03-06·The Journal of Physical Chemistry A

Nonlinear Optics Materials Designed by Intramolecular Boron- and Nitrogen-Locking Strategies: Exploring Torsion Angle Descriptors

Article

作者: Lin, Shichen ; Li, Bo ; Gu, Feng Long

Gaining mechanistic insights into the structure-performance relationship connecting the donor and acceptor is essential to the rational design of high performance nonlinear optics (NLO) materials. Here, intramolecular boron/nitrogen (B/N)-locking strategies in combination with various electron-withdrawing groups, R (R = TXO, DPzS, TTR, DPyS, DTC, DSCZ, DMPS and TXO2), are proposed to address this issue. With the decreasing of torsion angles (θ₁ and θ₂) between donor (TPA) and acceptor (Py-Ph) units, the first hyperpolarizability (β) values are increased 45-65% and 4-27% by intramolecular B/N-locking strategies, respectively. Intriguingly, we also found some good linear correlations between θ₁, θ₂, and lgβ (where the determination coefficient R² ranges from 0.84 to 1.00). Meanwhile, between θ₁, θ₂, and the excited energy (ΔE) of the crucial excited state there have also good correlations, namely, the R² ranges from 0.80 to 1.00. As a result, given the fact of finding results, one can draw some meaningful insights, namely, intramolecular B/N-locking strategies hold good application perspective for enhancing β, and θ₁ and θ₂ can serve as effective descriptors in designing high-performance NLO materials based on the D-A architecture system.

100 项与 2′,4′-Dimethoxychalcone 相关的药物交易

登录后查看更多信息

研发状态

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
细菌感染	临床前	中国	Shandong University of Traditional Chinese Medicine	2024-05-17
炎症	临床前	中国	Shandong University of Traditional Chinese Medicine	2024-05-17