布拉地新钠(Bucladesine Sodium) - 药物靶点：cGMP-PDE_在研适应症：褥疮，皮肤溃疡，心室功能不全_专利_临床

概要

基本信息

药物类型

小分子化药

别名

3',5'-cyclic AMP dibutyrate、Bucladesine、Bucladesine sodium (JAN)

+ [17]

靶点

cGMP-PDE

作用机制

cGMP-PDE抑制剂(cGMP-磷酸二酯酶抑制剂)

治疗领域

心血管疾病皮肤和肌肉骨骼疾病

在研适应症

褥疮皮肤溃疡心室功能不全

非在研适应症-

原研机构

Alfresa Pharma Corp.

在研机构

Alfresa Pharma Corp.Nipro Pharma Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1984-07-24),

心室功能不全

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C18H24N5NaO8P

InChIKeyWAOODRHZYQRSDS-JBVYASIDSA-N

CAS号16980-89-5

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关联

2

项与布拉地新钠相关的临床试验

CTR20233188

/ Not yet recruitingN/A

评价注射用二丁酰环磷腺苷钠在中国成年健康受试者中的一项单中心、随机、开放条件下单次给药、两制剂、两周期交叉的生物等效性研究

主要研究目的：考察单次静脉泵入300mg受试制剂注射用二丁酰环磷腺苷钠和参比制剂注射用二丁酰环磷腺苷钠在中国成年健康受试者体内的药代动力学特征，初步评估两种制剂的生物等效性。次要研究目的：评价单次静脉泵入300mg受试制剂和参比制剂在中国成年健康受试者中的安全性。

开始日期-

申办/合作机构

湖南尔康制药股份有限公司

JPRN-jRCT2041210065

/ Recruiting临床1/2期IIT

A Phase I/II Multi-Institutional Study of Bucladesine in Patients with Severe Methylmalonic Acidemia - McAMP

开始日期2022-03-10

申办/合作机构-

100 项与布拉地新钠相关的临床结果

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100 项与布拉地新钠相关的转化医学

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100 项与布拉地新钠相关的专利（医药）

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6,044

项与布拉地新钠相关的文献（医药）

2025-03-01·Reproductive Biology

Temporal optimization of meiotic arrest for enhancing oocyte maturity during in vitro maturation of porcine median antral follicles

Article

作者: Song, Beak ; Namkung, Ha Rin ; Han, Ji Won ; Lee, Seung Tae ; Jung, Su Bin ; Lee, Eun Song ; Nam, So Yeon

During in vitro maturation (IVM), median antral follicles (MAFs) were mechanically aspirated from the porcine ovarian cortex, and this process causes an early disconnection of follicular somatic cells from oocytes within antral follicles before the formation of graafian follicles. Thus, nuclear maturation is accelerated ahead of the completion of cytoplasmic maturation. Dibutyryl-cAMP (dbcAMP), a well-known cAMP modulator, is used to inhibit the resumption of meiosis in immature oocytes. However, there is no information on the optimal timeframe for sustaining meiotic arrest to enhance oocyte maturity during IVM. To determine the optimal duration of meiotic arrest, immature cumulus-oocyte complexes (COCs) from MAFs were cultured with 1 mM dbcAMP for 0, 4, 8, 12, 16, or 22 h, followed by further IVM without dbcAMP for 44, 40, 36, 32, 28, or 22 h. Subsequently, nuclear maturation, cumulus cell expansion score, perivitelline space size, glutathione (GSH) and reactive oxygen species (ROS) levels, and preimplantation development of parthenogenetic and in vitro-fertilized embryos were assessed in oocytes from each group. The results showed that a 16-h treatment with 1 mM dbcAMP within the 44-h IVM process yielded the highest oocyte maturity. Accordingly, we established an advanced IVM protocol for producing oocytes with superior maturity from porcine MAFs by achieving nuclear maturation 36 h after initiating IVM, using a 16-h treatment with 1 mM dbcAMP within the 44-h IVM process.

2025-02-01·Current Opinion in Chemical Biology

Illuminating anions in biology with genetically encoded fluorescent biosensors

Review

作者: Cook, Mariah A ; Tutol, Jasmine N ; Phelps, Shelby M ; Dodani, Sheel C ; Adams, Derik A

Anions are critical to all life forms. Anions can be absorbed as nutrients or biosynthesized. Anions shape a spectrum of fundamental biological processes at the organismal, cellular, and subcellular scales. Genetically encoded fluorescent biosensors can capture anions in action across time and space dimensions with microscopy. The firsts of such technologies were reported more than 20 years for monoatomic chloride and polyatomic cAMP anions. However, the recent boom of anion biosensors illuminates the unknowns and opportunities that remain for toolmakers and end users to meet across the aisle to spur innovations in biosensor designs and applications for discovery anion biology. In this review, we will canvas progress made over the last three years for biologically relevant anions that are classified as halides, oxyanions, carboxylates, and nucleotides.

2025-01-01·Journal of Diabetes Investigation

The benefits and accuracy of real‐time continuous glucose monitoring in children and adolescents with type 1 diabetes attending a summer camp

Article

作者: Morinaga, Jun ; Kondo, Tatsuya ; Kubota, Naoto ; Nishida, Kenro ; Yano, Mayumi ; Miyashita, Azusa ; Senokuchi, Takafumi ; Takeda, Haruo

ABSTRACTAims/IntroductionThis study evaluated the usability, satisfaction, and accuracy of a real‐time continuous glucose monitoring (rt‐CGM) in children and adolescents with type 1 diabetes (T1D) attending a summer camp.Materials and MethodsSeven children and adolescents with T1D (camper) and 31 of healthcare providers (HCPs) participating in a 2‐day summer camp in Kumamoto, Japan were enrolled. The usability and satisfaction were evaluated by tailored questionnaire. The accuracy of rt‐CGM was evaluated using self‐monitoring of blood glucose (BG) and sensor glucose (SG) values before or after (off camp) and during (on camp) the camp.ResultsThe score of the usefulness of rt‐CGM showed 3.29 ± 0.90 in campers and 4.23 ± 0.87 in HCPs (P = 0.017). The degree of recommendation score for rt‐CGM was 3.29 ± 1.11 in campers and 4.23 ± 0.79 in HCPs (P = 0.013). Time in range (TIR) off camp was 45.9% and that on camp was 57.0%. Time above range (TAR) off camp was 53.4% and that on camp was 42.4%. The mean absolute relative difference (MARD) off camp was 19.7% ± 25.2%, whereas that on camp was 16.0% ± 14.8% (P = 0.367). Clinically acceptable zones of the error grid analyses were approximately 96% in total.ConclusionsRt‐CGM exhibited higher usability and recommendation scores in HCPs than those in campers. This may be related to relatively lower accuracy in rt‐CGM. Overall usability and recommendation are clinically satisfactory, but due to relatively low accuracy, no decision should be made based on a single, non‐verified SG value alone.

100 项与布拉地新钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01238	布拉地新钠	C01CE04	DB13242

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
褥疮	日本	Nipro Pharma Corp.	1993-01-19
皮肤溃疡	日本	Nipro Pharma Corp.	1993-01-19
心室功能不全	日本	Alfresa Pharma Corp.	1984-07-24

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASGCT2004	N/A	口腔肿瘤	-	Ganciclovir	醖觸觸襯壓艱鑰構遞鏇(醖鬱鬱襯淵繭艱簾餘襯) = 簾廠窪淵繭獵襯積衊鹹齋簾窪築衊製構窪艱醖 (齋製廠鹹衊餘壓膚齋壓 )	-	2004-05-01
				Dibutyryl-cAMP	簾鏇觸衊蓋鹹顧壓積廠(範夢蓋範膚襯遞蓋窪積) = 範鏇窪選簾網製蓋繭繭繭餘艱淵積製窪構糧齋 (築衊鹽廠觸壓繭製淵製 )