更新于：2024-11-26
Ergoloid Mesylates
甲磺酸二氢麦角碱
更新于：2024-11-26
概要
基本信息
药物类型 小分子化药 |
别名 co-dergocrine mesilate、Co-dergocrine Mesylate、co-dergocrine methanesulfonate + [29] |
作用机制 α-adrenergic receptor拮抗剂(α-肾上腺素能受体家族拮抗剂) |
治疗领域 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 美国 (1953-11-05), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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关联
2
项与 甲磺酸二氢麦角碱 相关的临床试验An Exploratory Single Blind Study of Ergoloid Mesylates, 5-Hydroxytryptophan, and the Combination in Adult Males With Fragile X Syndrome
Dihydroergotoxine mesylate for the treatment of sialorrhea in Parkinson's disease
100 项与 甲磺酸二氢麦角碱 相关的临床结果
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100 项与 甲磺酸二氢麦角碱 相关的转化医学
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100 项与 甲磺酸二氢麦角碱 相关的专利（医药）
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1,236
项与 甲磺酸二氢麦角碱 相关的文献（医药）2024-10-18Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
Contaminants and residues have varied distributions in large volumes of wheat.
Article
作者: Timofeiev, Valentina ; Huang, Mei ; Serda, Maria ; Tittlemier, Sheryl A ; Drul, Dainna ; Tran, Michael ; Roscoe, Mike ; Gaba, Don ; Blagden, Richard ; Chan, Jason ; Richter, Anja
Analysis of bulk wheat consignments for naturally-occurring contaminants and residues from plant protection products is common, and helps manage potential health risks to consumers. The heterogeneous distribution of some mycotoxins in wheat has been described, however the distribution of other contaminants and residues has not yet been reported. This study characterized distributions of deoxynivalenol, ochratoxin A, ergot alkaloids, cadmium, and glyphosate in nine large consignments of wheat by analysing composite samples representing sub-lots prepared from increments obtained during the entire loading process. The widest span of concentrations within a consignment occurred for ochratoxin A (<0.5-22.9 µg/kg) and ergot alkaloids (0.009-0.486 mg/kg), followed by deoxynivalenol (<0.05-0.76 mg/kg) and glyphosate (<0.3-5.01 mg/kg), and then cadmium (0.022-0.102 mg/kg). Experimental semivariograms were plotted to model the spatio-temporal correlation of analytes within consignments during loading. Analyses demonstrated that distributions of contaminants and residues within a particular consignment differed, and that distributions of a particular contaminant or residue differed among consignments. The results indicate that sampling during only a portion of a loading or unloading process can result in a composite sample that is not representative of the consignment and thus increase the risk of misclassifying a consignment as compliant.
2024-10-01CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
Effects of exposure to chronic ergot alkaloids on phenylephrine contractile response of maternal pedal artery, umbilical artery, and umbilical vein in pregnant ewes.
Article
作者: Blakley, Barry ; Desai, Kaushik ; Yonpiam, Rossalin ; Al-Dissi, Ahmad
Ergot alkaloids are known to cause devastating effects in livestock. The objectives of this study were to evaluate the effects of prolonged ergot exposure on selected vasculature in pregnant sheep and to examine the role of alpha-1 adrenergic receptors in mediating these effects. Twelve 60-day pregnant sheep were randomly placed into control and exposure groups (n = 6/group). Ergot-contaminated feed pellets were given orally once a day for 45 d to the exposure group [46.6 μg/kg body weight (BW) total ergot alkaloids]. The control group (Ctl) received ergot-free pellets. The maternal pedal artery from the left hindlimb and the umbilical artery and vein were dissected and mounted in a tissue bath. The vascular contractile response to a cumulatively increasing dose of phenylephrine (PE) in the exposure group (Exp) was compared with the control groups. Chronic exposure to ergot alkaloids resulted in a 70.6% and 91.3% increase in PE contractile response in the umbilical artery (Ctl EC50 = 3.962 × 10-6; Exp EC50 = 1.161 × 10-6, P < 0.0001) and the umbilical vein (Ctl EC50 = 7.889 × 10-6; Exp EC50 = 6.801 × 10-7, P < 0.0001), respectively, but there was no increase in the pedal artery (P = 0.3927), when compared to the control group. Fetal weight in the ergot-exposed group was significantly lower than in the control group (Ctl 3.3 ± 0.17 kg; Exp 2.07 ± 0.13 kg, P = 0.0002). The increase in contractile response in the umbilical vein may result in decreased blood supply to the fetus causing decreased fetal weight. Negative impact was seen at significantly lower levels of ergot alkaloids than what is currently allowed by Canadian standards, which suggests that these limits should be reevaluated to ensure livestock safety.
2024-04-01Molecular diversity
Evaluation of the interaction between potent small molecules against the Nipah virus Glycoprotein in Malaysia and Bangladesh strains, accompanied by the human Ephrin-B2 and Ephrin-B3 receptors; a simulation approach
Article
作者: Alijanianzadeh, Mahdi ; Ebrahimi, Maryam
Malaysia reported the first human case of Nipah virus (NiV) in late September 1998 with encephalitis and respiratory symptoms. As a result of viral genomic mutations, two main strains (NiV-Malaysia and NiV-Bangladesh) have spread around the world. There are no licensed molecular therapeutics available for this biosafety level 4 pathogen. NiV attachment glycoprotein plays a critical role in viral transmission through its human receptors (Ephrin-B2 and Ephrin-B3), so identifying small molecules that can be repurposed to inhibit them is crucial to developing anti-NiV drugs. Consequently, in this study annealing simulations, pharmacophore modeling, molecular docking, and molecular dynamics were used to evaluate seven potential drugs (Pemirolast, Nitrofurantoin, Isoniazid Pyruvate, Eriodictyol, Cepharanthine, Ergoloid, and Hypericin) against NiV-G, Ephrin-B2, and Ephrin-B3 receptors. Based on the annealing analysis, Pemirolast for efnb2 protein and Isoniazid Pyruvate for efnb3 receptor were repurposed as the most promising small molecule candidates. Furthermore, Hypericin and Cepharanthine, with notable interaction values, are the top Glycoprotein inhibitors in Malaysia and Bangladesh strains, respectively. In addition, docking calculations revealed that their binding affinity scores are related to efnb2-pem (- 7.1 kcal/mol), efnb3-iso (- 5.8 kcal/mol), gm-hyp (- 9.6 kcal/mol), gb-ceph (- 9.2 kcal/mol). Finally, our computational research minimizes the time-consuming aspects and provides options for dealing with any new variants of Nipah virus that might emerge in the future.
3
项与 甲磺酸二氢麦角碱 相关的新闻（医药）2022-08-30
2022-08-18
2022-07-27
100 项与 甲磺酸二氢麦角碱 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 头痛 | 中国 | 1999-08-13 | |
| 痴呆 | 美国 | 1953-11-05 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 15 | Matching placebo for 5-Hydroxytryptophan+Ergoloid Mesylates (Ergoloid Mesylates (EM)) | 衊壓獵遞廠鹹衊艱築鹹(鑰醖夢顧窪憲糧繭積製) = 蓋醖窪鏇艱選構繭襯餘 選簾顧製壓構鹹醖淵糧 (鑰鹹齋觸夢製齋衊鹽鏇, 繭鹽醖廠廠鹹膚窪顧製 ~ 選襯顧窪製膚廠積餘憲) 更多 | - | 2024-09-19 | ||
(Ergoloid Mesylates (EM) and 5-hydroxytryptophan (5-HTP)) | 衊壓獵遞廠鹹衊艱築鹹(鑰醖夢顧窪憲糧繭積製) = 夢膚選齋範窪艱鑰襯製 選簾顧製壓構鹹醖淵糧 (鑰鹹齋觸夢製齋衊鹽鏇, 鹽壓壓簾製製醖鏇憲廠 ~ 鏇糧獵顧築廠糧廠憲構) 更多 |
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