The goal of this clinical trial is to learn about the use of turmeric (Curcumin) as a treatment for pain of thumb-joint arthritis. Turmeric is commonly being used as an over-the-counter treatment for musculoskeletal pain. Clinical trials have demonstrated a pain-relief benefit for knee osteoarthritis, however no clinical trial has been performed to establish efficacy of curcumin in humans for thumb-joint arthritis. The main question[s] it aims to answer are:
Is Turmeric more effective than placebo at relieving pain for thumb-joint arthritis? A placebo is a look-alike substance that contains no active drug.
Is Turmeric more effective than placebo at improving patient-reported outcomes for CMC arthritis?
Is Turmeric safe for participants with thumb-joint arthritis?
Participants will:
take 4 weeks of daily Turmeric capsules,
take 4 weeks of daily placebo capsules
answer daily surveys about how they are feeling and functioning.

开始日期2024-06-01

申办/合作机构

University of Virginia

NCT05816707 / Recruiting临床1期IIT

The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh Extraction Sockets; Randomized Controlled Clinical Trial.

The study will be conducted on 30 patients with split mouth design patients will be divided into curcumin and PRF groups patients will have bilateral tooth extraction one side will receive curcumin/PRF and the other side will be control soft tissue healing and bone quality will be evaluated post-operative

开始日期2024-05-01

申办/合作机构-

NCT06044025 / Recruiting临床1期IIT

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

The goal of this clinical trial is to assess the feasibility of adding a combination of metformin and turmeric as part of a nutritional intervention regimen to the current standard of care, namely, intermittent Androgen Deprivation Therapy (iADT), for patients with castration sensitive biochemical progressive prostate cancer.
The main objectives are:
Assess the feasibility of the study population and enrollment.
Evaluate time to PSA relapse with nutritional intervention on iADT.
Participants who are receiving iADT will be dispensed Metformin and turmeric and complete a pill diary. Participants will also have blood and stool samples collected and complete quality of life questionnaires.
The long-term goal is to further assess the efficacy and safety of this nutritional regimen and the roles of metabolic syndrome, microenvironment/microbiome, and genomic vs epigenomic profiles in the care of these patients through a clinical trial.

开始日期2024-04-11

申办/合作机构

Arkansas State University

100 项与姜黄提取物相关的临床结果

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100 项与姜黄提取物相关的转化医学

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100 项与姜黄提取物相关的专利（医药）

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210

项与姜黄提取物相关的文献（医药）

2024-03-01·Journal of insect physiology

Super food or super toxic? Turmeric and spirulina as culprits for the toxic effects of food dyes in Drosophila

Article

作者: Derous, Davina ; Morimoto, Juliano ; Christie, Craig ; von Hellfeld, Rebecca

Prolonged exposure to food dyes, even for those considered safe for consumption, are known to have toxic effects. However, we lack a proper understanding of the underlying compounds that are responsible for the observed toxicity. Here, we tested the toxic effects of three common commercially available natural food dyes (red, green, blue), and their main ingredients (turmeric and spirulina), on Drosophila melanogaster oviposition, larval development, and larval foraging behaviour. Larval development and egg-to-adult survival was significantly impacted by blue and green dyes. These effects were recapitulated when flies were fed with increasing concentrations of turmeric and spirulina, suggesting that turmeric is a toxic component of the food dye. Red dye, which contains neither turmeric or spirulina, had little impact on fly health and behaviour. Green and blue food dyes decreased egg laying, an effect similar to that observed in increasing concentrations of turmeric and, to a lesser extent, spirulina. When given a choice, larvae preferred to feed as follows: control > red > blue > green diet patches, a pattern inversely correlating with the previously observed toxicity. Our results show that, despite turmeric being often considered a super food, it can have toxic effects that the impact health of organisms.

2024-02-01·International journal of biological macromolecules

Development of nanofibrous scaffolds containing polylactic acid modified with turmeric and hydroxyapatite/vivianite nanoparticles for wound dressing applications

Article

作者: Hamed, Amr ; Mostafa, Mervat S ; Yousef, Hesham ; Mourad, Ibrahim ; Ashraf, Sherif ; Khalaf, Mohamed

Damaging the outer layer of the body (the skin) has been a common issue for decades. Fabrication of nanofibrous membranes via the electrospinning technique for the sake of making the wound healing process more facile has caught a lot of interest. For this purpose, a polymeric scaffold of polylactic acid (PLA) was doped with nanoparticles with different concentrations of turmeric/hydroxyapatite/vivianite/graphene oxide. The obtained membrane was tested by XRD, SEM, FTIR, and XPS. The surface topography of the scaffold has experienced changes upon adding different concentrations of the nanoparticles. The contact angle was measured by water droplets. It accentuated change in CA starting from 43.9^o for pure condition of PLA to 67.7^o for PLA/turmeric/vivianite. The thermogravimetric analysis (TGA) test stated that the PLA scaffold features are thermally stable in relatively high-temperature conditions initiating from room temperature to about 300 °C, meeting the maximum loss in mass of about 5 %. The cell viability was carried out in prepared vitro for the sample which contains PLA/turmeric/vivianite/GO, it was elucidated that the IC₅₀ was around 3060 μg/ml.

2024-02-01·Clinical nutrition ESPEN

Curcumin/turmeric supplementation could improve blood pressure and endothelial function: A grade-assessed systematic review and dose–response meta-analysis of randomized controlled trials

Review

作者: Askarpour, Moein ; Dehzad, Mohammad Jafar ; Ghalandari, Hamid

BACKGROUND AND PURPOSE:

A number of studies have examined the impact of curcumin/turmeric on blood pressure and the factors allegedly responsible for hypertension. In this systematic review and meta-analysis, we tried to sum up the existing literature on randomized controlled trials (RCTs) investigating this hypothesis.

METHODS:

Online databases (PubMed, Scopus, Web of Science Core Collection, Cochrane Library, and Google Scholar) were searched from inception up to October 2022. We used the cochrane quality assessment tool to evaluate the risk of bias. Outcomes of interest included systolic blood pressure (SBP), diastolic blood pressure (DBP), blood levels of vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1), flow-mediated vasodilation (FMD), and pulse-wave velocity (PWV). Weighted mean differences (WMDs) were derived and reported. In case of significant between-study heterogeneity, subgroup analyses were carried out. Significance level was considered as P-values<0.05.

RESULTS:

Finally, 35 RCTs out of 4182 studies were included. Our findings suggested that curcumin/turmeric supplementation significantly improved SBP (WMD: -2.02 mmHg; 95 % CI: -2.85, -1.18), DBP (WMD: -0.82 mmHg; 95 % CI: -1.46, -0.18), VCAM-1 (WMD: -39.19 ng/mL; 95 % CI: -66.15, -12.23), and FMD (WMD: 2.00 %; 95 % CI: 1.07, 2.94). However, it did not significantly change levels of ICAM-1 (WMD: -17.05 ng/ml; 95 % CI: -80.79, 46.70), or PWV (WMD: -79.53 cm/s; 95 % CI: -210.38, 51.33).

CONCLUSION:

It seems that curcumin/turmeric supplementation could be regarded as a complementary method to improve blood pressure and endothelial function. However, further research is needed to clarify its impact on inflammatory adhesion molecules in the circulation.

项与姜黄提取物相关的新闻（医药）

2024-04-25

·米内网

【聚焦】25个国谈药、紧缺新药拟进院，独家品种“霸屏”

精彩内容4月24日，德阳市第六人民医院公示称，拟引进25款通过专家综合比选评审的国谈药及紧缺新药，其中独家品种（含独家剂型，下同）占比超过50%；从企业层面上看，科伦药业、神威药业等拟进入采购目录产品数均在2个及以上。来源：德阳市第六人民医院官网按治疗大类统计，此次德阳市第六人民医院拟引进的药物以血液和造血系统化学药、肌肉-骨骼系统化学药、消化系统及代谢化学药为主，分别占据6个、4个和3个席位；骨骼肌肉系统疾病中成药、心脑血管疾病化学药以及呼吸系统化学药则各占2个。25个拟引进的药品中，注射剂为主力军，有11个产品入围，胶囊剂（5个）、片剂（3个）等位居其后；其中独家品种有14个，占比超五成。从企业层面上看，科伦药业、神威药业等拟进入采购目录产品数均在2个及以上。拟进院品种名单注：带*为独家品种来源：德阳市第六人民医院官网，米内网整理作为国内大输液龙头，科伦药业有3款注射剂拟新增进院，包括氯化钠注射液、葡萄糖注射液以及唑来膦酸注射液，均为国家医保目录品种。米内网数据显示，在中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院（简称中国公立医疗机构）终端，上述3个品种2023年上半年销售规模分别超过100亿元、35亿元、3亿元，科伦药业（按集团统计）分别以约27%、33%和26%的份额领跑市场。科伦药业3款注射剂在中国公立医疗机构终端的市场份额来源：米内网中国公立医疗机构药品终端竞争格局神威药业是一家以新中药产业为主业的综合性企业集团，此次共有2个品种新增进院，分别是芪黄通秘软胶囊和降脂通络软胶囊，均为公司的独家中成药。其中，芪黄通秘软胶囊主要由黄芪、肉苁蓉、熟大黄、决明子等组成，具有益气养血、润肠通便的功效，用于功能性便秘辨证属“虚秘”者；而降脂通络软胶囊主要成分为姜黄提取物，功能主治活血行气、降脂祛浊，用于高脂血症属血瘀气滞证者，症见胸闷、胀痛、心前区刺痛、脉搏细弱等。近年来，上述2款中成药在中国公立医疗机构终端均保持两位数及以上的销售增速，市场潜力可期。神威药业2款中成药在中国公立医疗机构终端的销售增速来源：米内网中国公立医疗机构药品终端竞争格局此外，拟进院的新药名单中还包括湖南九典制药的酮洛芬凝胶贴膏、一力制药的虎贞清风胶囊、华春生物药业的参葛补肾胶囊、江苏柯菲平医药的盐酸凯普拉生片、南京华盖制药的盐酸丙卡特罗吸入溶液等，覆盖肌肉-骨骼系统、神经系统疾病用药、消化系统及代谢药、呼吸系统用药等多个治疗大类，满足不同患者的临床用药需求。资料来源：米内网数据库、德阳市第六人民医院官网注：米内网《中国公立医疗机构药品终端竞争格局》，统计范围是：中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院，不含民营医院、私人诊所、村卫生室；上述销售额以产品在终端的平均零售价计算。数据统计截至4月25日，如有疏漏，欢迎指正！本文为原创稿件，转载请注明来源和作者，否则将追究侵权责任。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092【分享、点赞、在看】点一点不失联哦

带量采购

2024-02-12

·PRNewswire

Immune Support Matters: OjasTee Redefines Wellness with its Immune-Boosting Spice-Based Products

BERKELEY, Calif., Feb. 12, 2024 /PRNewswire/ -- OjasTee LLC, a California-based company founded in 2020 by retired physician Dr. Rajah Sekaran and former biotech scientist Bob Milley, is making waves in the wellness industry with its innovative approach to immune health. Inspired by the challenges posed by the COVID-19 and its variants, OjasTee is on a mission to provide wellness products. Continue Reading Golden Latte TURMERIC Mix (200 Grams) OjasTee products Spices Are an Effective Way to Combat Inflammation and Boost Immunity The 7-spice blend, carefully curated with ingredients like Turmeric, Cumin, Cinnamon, Ginger, Nutmeg and Pepper aims to support the immune system through its potent antioxidant and anti-inflammatory qualities. Pepper in OjasTee's products promotes absorption of Turmeric 2000%. A Spice-Based Journey to Health OjasTee encourages the consumption of these spices as Dietary Supplement in various forms, including Teas, Golden Latte, Seasonings for all cuisines, and Rubs for fish, meat, and vegetables. Quality Assurance and Certification All spices, teas, herbs, and ingredients undergo rigorous testing by suppliers and co-packers. The company's dedication to quality is further emphasized by its certification from the Western Regional Minority Supplier Development Council (NMSDC), ensuring that OjasTee meets the standards for promoting HEALTH and WELLNESS. Merieux NutriSciences labs certified the presence of Curcuminoid, the active component in Turmeric and a major ingredient in all of OjasTee's products. Turmeric being antioxidant by itself converts inactive antioxidants from other foods to active antioxidants as well. Meet the Visionary Behind OjasTee Dr. Rajah Sekaran, the founder, brings a wealth of experience as a retired physician. His extensive background in medicine and philosophy led to the creation of OjasTee's spice blend. OjasTee's Philosophical Approach Dr. Sekaran's commitment to health is reflected in his recent publications, "Tennis Made Easy and Yoga of Mind and Body" and "Beyond Mind–The Next Step in Human Evolution," which outlines the Feedback Theory. This theory emphasizes the interconnectedness of internal and external environments, highlighting the need for a balanced lifestyle to maintain optimal health. Support Your Immune Health OjasTee advocates lifestyle changes at both the mental and physical levels. The company encourages kindness with good intentions and stress management at the mental level. At the physical level, OjasTee promotes a balanced diet with adequate exercise, emphasizing the inclusion of spices and herbs for their antioxidant and anti-inflammatory properties. For more information about OjasTee and its transformative products, visit . Media Contact: M Rajah Sekaran [email protected] 510-496-1077 SOURCE OjasTee

2024-01-25

·PRNewswire

brelixi® Introduces Fast-Acting + Flavorless Functional Powders In CBD And THC Formats

Transforming Cannabis Consumption: brelixi Introduces Multi-Use, Dissolvable Powder In Eco-Friendly, Refillable Jars NEW YORK, Jan. 25, 2024 /PRNewswire/ -- In a pioneering move that epitomizes brelixi®'s commitment to innovation, the nano-cannabis company is shaking up the scene with the launch of its flavorless + functional fast-acting powders. Available in both THC and CBD formats, this release marks a significant stride toward merging the wellness and cannabis industries. Continue Reading brelixi's flavorless + functional CBD and THC formats are now available in eco-friendly, refillable tubes. Save 15% on both SKUs with a subscription flavorless + functional fast-acting powders are eco-friendly, refillable and available in CBD and THC formats brelixi's flavorless + functional fast-acting powders empower consumers to enjoy the benefits of functional ingredients and cannabis however they'd prefer. With precise dosing capabilities, this discreet and 100% customizable nano powder can withstand temperatures up to 400 degrees, making it ideal for baking and incorporating into various cuisines, cocktails, mocktails, coffees, or smoothies. These flavorless powders use advanced nano-emulsification for optimized cannabinoid absorption, ensuring increased bioavailability and rapid onset of effects. Enhanced with adaptogen L-theanine, magnesium, and nootropic 5-HTP from griffonia seed extract, brelixi guarantees the highest standards of quality and potency for a no-wait, immediate vibe. "I designed our flavorless + functional powders to fill a gap I'd personally experienced in the market," says brelixi Founder and Chief Food Scientist Breanna Neff. "There's no other product that provides consumers speed, functionality, and seamless integration into daily rituals. Whether mixed into your morning coffee to soothe caffeine jitters, or infused into cookies for an elevated experience, our powders are designed for multifaceted consumption to ensure confidence and consistency in infused moments." Brelixi's flavorless + functional fast-acting powders are housed in a durable, reusable, food grade compostable jar with a brushed gold top and sustainable bamboo scoop. Now available for one-time purchase, or in a monthly subscription for 15% off with free shipping, this refillable, eco-friendly subscription enables users to replenish their jars cost-effectively. For relaxation, brelixi's flavorless CBD nano powder provides 20 mgs of CBD per serving, with 30 servings per jar (600 mg) available for $59.99. With a choice of a 30 or 45-day subscription, unflavored nano CBD jars can be easily refilled for $50.99. For elevation, brelixi's flavorless THC nano powder offers 5 mgs of THC per scoop, with 20 servings per jar (100 mg) at $44.70 without a subscription, and $38.00 every 20, 30, or 45 days with a subscription. brelixi now offers four sku's, including Yuzu + Turmeric Lemonade (20mg THC) and Elderberry + Hibiscus Lemonade (30mg CBD), which start at $12 per stick or $45 per 5-pack box. Find them at brelixi.com, and specialty wellness stores nationwide (subject to state regulations). Explore more at . About brelixi ® brelixi® is a revolutionary Black Woman + Queer-Founded wellness brand at the forefront of the functional beverage industry, specializing in cannabis-infused powder mixes & beverages. Led by Founder and Chief Food Scientist Breanna Neff, brelixi is dedicated to merging the realms of science and wellness. Utilizing its exclusive nano cannabis technology, brelixi delivers rapid onset times along with the benefits of nootropics, electrolytes, adaptogens, and antioxidants. Learn more at and connect with us on social media @brelixi. Media Contact: T-Aira Jelks HYPH PR [email protected] 310.694.0895 Breanna Neff brelixi [email protected] 646.626.6610 SOURCE brelixi

100 项与姜黄提取物相关的药物交易

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02782949 (CTgov)	临床2期	癌变 \| 萎缩性胃炎 \| 胃癌	50	Quality-of-Life Assessment+Curcumin (Arm I (Curcumin))	鹽願淵窪遞製廠糧鑰蓋(憲衊獵淵築膚繭範積獵) = 遞廠築醖顧顧鑰鑰衊齋衊膚鹽獵鬱餘襯鏇製糧 (壓願衊鹹襯壓蓋積選繭, 網廠衊簾鹹壓廠壓醖窪 ~ 窪淵糧觸製觸蓋鬱鏇鹹) 更多	-	2024-03-05
				Quality-of-Life Assessment (Arm II (Placebo))	鹽願淵窪遞製廠糧鑰蓋(憲衊獵淵築膚繭範積獵) = 廠淵廠築衊顧鬱蓋簾膚衊膚鹽獵鬱餘襯鏇製糧 (壓願衊鹹襯壓蓋積選繭, 鏇範鬱蓋觸淵醖築壓膚 ~ 醖壓襯顧獵衊餘鑰淵夢) 更多
ASN2021	N/A	草酸钙肾石病	-	Turmeric 2g daily	製蓋網鏇醖遞蓋憲憲餘(糧窪鬱願簾鹹簾鬱觸構) = 範鏇蓋襯願蓋範築糧鹽築築鑰夢夢構艱觸糧憲 (繭壓壓壓選觸餘範製廠 ) 更多	不佳	2021-10-27
TCTR20180131001 (Pubmed)	临床3期	餐后窘迫综合征	78	Curcuma longa 750 mg	築淵鬱廠顧遞淵鏇壓願(衊鏇選艱構選鹹蓋齋艱) = 遞廠願膚齋醖艱鹹鬱醖範願顧夢願憲製製夢齋 (壓醖範憲積鹹繭醖獵繭 )	-	2019-01-01
				Curcuma longa 1500 mg	築淵鬱廠顧遞淵鏇壓願(衊鏇選艱構選鹹蓋齋艱) = 艱範簾憲積醖餘蓋願醖範願顧夢願憲製製夢齋 (壓醖範憲積鹹繭醖獵繭 )
NCT00641147 (CTgov)	临床2期	腺瘤性结肠息肉病	44	Laboratory Biomarker Analysis+Curcumin (Arm I (Curcumin))	憲襯壓餘淵艱淵鑰繭淵(願餘窪網壓糧壓鑰願鏇) = 願鑰餘築顧齋蓋糧齋鏇顧簾淵獵窪淵範襯鹹淵 (醖構築壓鏇糧網鹽醖鏇, 蓋簾觸範衊鏇獵鬱夢窪 ~ 觸顧網衊顧簾顧壓襯鑰) 更多	-	2017-09-29
				Placebo (Arm II (Placebo))	憲襯壓餘淵艱淵鑰繭淵(願餘窪網壓糧壓鑰願鏇) = 淵蓋餘鹽範顧築鹽製糧顧簾淵獵窪淵範襯鹹淵 (醖構築壓鏇糧網鹽醖鏇, 顧範鹹範衊願餘淵範鑰 ~ 窪壓遞憲膚鬱鏇範構醖) 更多