加莫烯酸(Gamolenic acid) - 在研适应症：特应性皮炎_专利_临床

概要

基本信息

药物类型

小分子化药

别名

(6,9,12)-linolenic acid、(6Z,9Z,12Z)-Octadecatrienoic acid、(Z,Z,Z)-6,9,12-octadecatrienoic acid

+ [16]

靶点-

作用方式

调节剂

作用机制

免疫调节剂

治疗领域

免疫系统疾病遗传病与畸形皮肤和肌肉骨骼疾病

在研适应症

非在研适应症

原研机构

在研机构

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

澳大利亚 (1994-07-15),

特应性皮炎

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构/序列

分子式C18H30O2

InChIKeyVZCCETWTMQHEPK-QNEBEIHSSA-N

CAS号506-26-3

关联

7

项与加莫烯酸相关的临床试验

ChiCTR2000037961

/ Recruiting临床4期IIT

Randomized controlled trial of efficacy and safety of non-antibiotic triple therapy containing linolenic acid and Polaprezinc for the first treatment of Helicobacter pylori infection

开始日期2020-09-01

申办/合作机构

南京医科大学第一附属医院

CTRI/2019/10/021569

/ Not yet recruitingN/AIIT

ASSESSMENT OF EFFECT OF NIMBA-AMALAKI YOGA IN COMPARISON WITH CAP GAMMA LINOLENIC ACID IN MANAGEMENT OF VICHARCHIKA OPEN RANDOMIZED CONTROL STUDY

开始日期2019-10-12

申办/合作机构-

JPRN-UMIN000027336

/ SuspendedN/AIIT

Clinical evaluations of autologous fibrin glue and polyglycolic acid sheets as preventing esophageal stricture after endoscopic submucosal dissection of superficial esophageal neoplasms - The efficacy of shielding method with autologous fibrin glue and polyglycolic acid sheets for the prevention of postoperative stricture after esophageal endoscopic submucosal dissection

开始日期2017-05-15

申办/合作机构-

100 项与加莫烯酸相关的临床结果

登录后查看更多信息

100 项与加莫烯酸相关的转化医学

登录后查看更多信息

100 项与加莫烯酸相关的专利（医药）

登录后查看更多信息

15,124

项与加莫烯酸相关的文献（医药）

2025-12-31·Italian Journal of Animal Science

Effects of dietary hemp co-product inclusion on laying hens performances and on egg nutritional and functional profile

作者: Lanzoni, D. ; Petrosillo, E. ; Rebucci, R. ; Skřivan, M. ; Englmaierová, M. ; Marchetti, L. ; Baldi, A. ; Giromini, C. ; Bontempo, V. ; Skřivanová, V.

Farm to Fork strategy aims to guide the agri-sector to sustainable food system.Hemp co-products are featured by an interesting nutritional and functional profile.The 9% inclusion of the hemp co-product improved the performance of laying hens and the nutritional and functional profile of eggs.

2025-09-01·Comparative Biochemistry and Physiology Part D: Genomics and Proteomics

Non-negative matrix factorization reveals seasonal and sex-specific metabolic tactics in tropical tilapia

Article

作者: Wang, Ching-Wei ; Lin, Ching-Chun ; Furukawa, Fumiya ; Lin, Tzu-Hao ; Wang, Min-Chen ; Tseng, Yung-Che

Understanding metabolic adaptations to seasonal fluctuations in ectothermic organisms is challenging, especially in tropical species where physiological responses are more pronounced than in temperate or polar counterparts. Traditional analytical methods often fail to account for the complex metabolic adjustments that are present in these substantial responses, and the high-dimensional characteristics of metabolomic data complicate the interpretation process when using conventional statistical methods. We utilized Non-negative Matrix Factorization (NMF), an unsupervised machine learning algorithm, to analyze monthly serum metabolomics data from tilapia over a year in order to overcome these limits. A deeper analysis using NMF demonstrated that carbohydrates gained prominence during warmer months, as evidenced by consistently elevated weights of glycolysis intermediates in our quantitative analysis. Furthermore, fatty acids remained an important factor in both warm and cold seasons. Amino acids emerged as particularly versatile metabolites, exhibiting adaptability during seasonal transitions. This flexibility suggests their crucial role in coordinating energy-related adaptations and potentially facilitating epigenetic and reproductive responses to changing environments. Serum aspartate composition during the warm-cold transition indicated sex-specific metabolic strategies, as sexual dimorphism was observed in the seasonal utilization of fatty acids and aspartate. Collectively, NMF objectively assesses the metabolic tactics of tropical fish and reveals latent patterns in real-world metabolic dynamics. Consequently, it possesses the potential to facilitate metabolomics-driven species conservation in response to environmental changes.

2025-08-01·Bioresource Technology

Advances in multi-omics technologies for identifying metabolic engineering targets and improving lipid production in microalgae

Review

作者: Xu, Lu-Wei ; Sun, Xiao-Man ; Yan, Chun-Xiao ; Zhang, Shuai ; Ma, Wang ; Gao, Han ; Zhang, Zi-Xu

Polyunsaturated fatty acids (PUFAs), such as γ-linolenic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid, are highly valued in the global market due to their physiological effects and health benefits. Concerns related to overfishing and marine ecosystem degradation have driven interest in microalgal lipids as a sustainable and eco-friendly alternative for PUFA production. Despite some success in commercializing microalgal lipid products, they still fail to meet global demand. Advances in high-throughput omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, have deepened the understanding of lipid biosynthesis in microalgae. This review explores the potential of multi-omics approaches to elucidate PUFA biosynthesis pathways, identify key regulatory genes, and optimize metabolic engineering strategies for enhanced lipid production. Additionally, this review discusses how multi-omics technologies address challenges in large-scale cultivation, promoting the industrialization of microalgal lipid productions. These insights provide a foundation for improving microalgal PUFA yields to meet growing global demand.

100 项与加莫烯酸相关的药物交易

登录后查看更多信息