印楝提取物(Azadirachta indica Extract) - 在研适应症：牙周炎_专利_临床

概要

基本信息

药物类型

中药

别名

Neem

靶点-

作用机制-

治疗领域

口颌疾病

在研适应症

牙周炎

非在研适应症-

原研机构

Ain Shams University

在研机构

Ain Shams University

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

10

项与印楝提取物相关的临床试验

CTRI/2024/10/075956

/ Not yet recruiting临床2/3期IIT

In vitro evaluation of antifungal activity of homoeopathic medicine Azadirachta indica against pityrosporum ovale and randomised controlled trial in patients with dandruff - NIL

开始日期2024-11-05

申办/合作机构-

CTRI/2024/10/074811

/ Not yet recruiting临床3期IIT

A randomised controlled trial to assess antifungal activity of Homoeopathic medicine Azadirachta indica against Pityrosporum ovale in patients with dandruff

开始日期2024-10-18

申办/合作机构

Patients Hospital

CTRI/2024/08/073102

/ Not yet recruitingN/A

Azadirachta Indica A Double Blind Randomized Placebo Controlled Parallel Study Homoeopathic Pathogenetic Trial in accordance to protocol given by Central Council ofResearch in Homoeopathy - nil

开始日期2024-09-14

申办/合作机构

Dr. Willmar Schwabe GmbH & Co. KG

100 项与印楝提取物相关的临床结果

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100 项与印楝提取物相关的转化医学

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100 项与印楝提取物相关的专利（医药）

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359

项与印楝提取物相关的文献（医药）

2024-12-01·Journal of dentistry (Shiraz, Iran)

Evaluation of the Effect of Applying Chitosan, Neem, Tulsi, Aloe vera, and Chlorhexidine Solutions on the Shear Bond Strength of Composite to Dentin.

Article

作者: Sharafeddin, Farahnaz ; Aghaei, Fatemeh

Statement of the ProblemDentin adhesion is challenging and needs modifications. Newly introduced nature-derived materials may be a useful solution in improving dentin adhesion. The use of natural antimicrobial agents for pretreating prepared dentin surfaces before restoration has become of interest.PurposeThe present study investigated the effect of natural compounds on the shear bond strength (SBS) of resin composite adhesively bonded to dentin.Materials and MethodSixty extracted human molar teeth were randomly divided into six groups (n= 10); Group I: two-step etch and rinse adhesive system, Adper Single Bond 2 (SB₂) (experimental control), Group II: 2.5% Chitosan+etch+SB₂, Group III: 15% Neem (Azadirachta indica)+etch+SB₂, Group IV: 15% Tulsi (Ocimum sanctum)+etch+SB₂, Group V: 2% Aloe vera+etch+SB₂, and group VI: 2% Chlorhexidine (CHX)+etch+SB₂. Resin composite (Z350, 3M ESPE USA) was placed over the prepared dentin surfaces and was light cured. Data analysis was performed using One-way ANOVA and post hoc Tukey's test (p< 0.05).ResultsNeem specimens showed the highest mean SBS, statistically greater than the control (p= 0.042). Other experimental groups showed no significant differences in SBS comparison to the control. The mean SBS values of 2.5% Chitosan, 15% Neem, 15% Tulsi, and 2% Aloe vera were significantly higher than 2% CHX (p= 0.046, p= 0.001, p= 0.010 and p= 0.002 respectively).ConclusionDentin pretreatment with Neem may improve the bond strength of a two-step etch and rinse adhesive system. The application of Chitosan, Tulsi, Aloe vera, and CHX did not demonstrate significantly different SBS values from that of the Control, although CHX was lower.

2024-09-04·Current Drug Delivery

Cell Culture and Molecular Docking Analysis to Determine the Antiviral Activity of Folklore Medicinal Plants Against Chikungunya Virus

Article

作者: Garg, Munish ; Kaushik, Samander ; Kumar, Sukender

Introduction:Chikungunya Virus (CHIKV), a mosquito-transmitted pathogen, poses a significant global health threat owing to its widespread prevalence and high morbidity. There are no approved vaccines or antivirals for prevention or treatment. Screening of folklore medicinal plants has emerged as a promising approach to finding novel therapeutics to combat pathogens. Hence, this study aimed to evaluate the anti-chikungunya potential of folklore medicinal plants and their phytochemicals.Methods:Maximum non-toxic concentrations (MNTD) of the extracts to Vero cells were determined by the cytotoxicity assay. A Focus-Forming Unit (FFU) assay was used to assess the antiviral activity of the extracts (at MNTD) against CHIKV in Vero cells under pre-, co-, and post-treatment conditions. GC-MS was used to detect the phytochemicals of the extracts, and Schrodinger (Maestro) software was employed for their molecular docking against the target protein of CHIKV.Results:Azadirachta indica exhibited anti-CHIKV activity during pre- and post-treatment, decreasing the virus titer from 8.145 to 7.998 and 8.361 to 8.040 mean log10 FFU/ml, respectively. Calendula officinalis and Piper retrofractum exhibited anti-CHIKV activity only during post-treatment (8.361 to 8.135, 8.361 to 8.075). Moreover, molecular docking studies of phytochemicals detected in GCMS analysis of all the extracts revealed that many phytochemicals (especially F3, F5, F6, and A1) could bind to the non-structural protein (nSP2) target of CHIKV and suppress the viral replication.Conclusion:The screened plants showed the ability to inhibit CHIKV infection and replication and hold potential for further investigation in developing treatments for Chikungunya.

2024-08-22·International Journal of Clinical Pediatric Dentistry

Comparative Evaluation of Microbial Reduction Using Silver Diamine Fluoride, Azadirachta indica (Neem) and Sodium Hypochlorite as Root Canal Irrigants after Biomechanical Preparation in Uniradicular Canals: An In Vivo Study

Article

作者: Dhinsa, Kavita ; Yadav, Gunjan ; Saha, Sonali ; Sharma, Prerna ; Raj, Shruti ; Sharma, Anshul ; Sharma, Prerna ; Dhinsa, Kavita ; Raj, Shruti ; Saha, Sonali ; Yadav, Gunjan

BackgroundIt is difficult to completely eradicate microorganisms from the infected root canal system. Intracanal irrigants seem necessary for eradication of infected tissues and microorganisms in addition to mechanical debridement. Continuous use of chemical antimicrobial agents leads to serious side effects. Therefore, the need arises for alternative agents to overcome the disadvantages of their chemical counterparts.AimTo evaluate and compare the antimicrobial efficacy of three endodontic irrigants against clinically isolated bacteria found in root canals containing necrotic pulp.Materials and methodsPreirrigation sample were collected using sterile paper points and sent for microbial count. Chemomechanical preparation was performed, and the root canals were irrigated with 5 mL of test samples. After 3 days, the patient was recalled, and a postirrigation sample was collected and sent for microbial count.Result synthesisBoth 3.8% silver diamine fluoride (SDF) and 3% sodium hypochlorite (NaOCl) showed a superior capacity to sterilize the root canals compared to the neem group.ConclusionThe use of SDF as an endodontic irrigant is feasible as it effectively removes the microbes present in the canal.Clinical significanceSilver diamine fluoride has not been shown to be cytotoxic or carcinogenic, unlike NaOCl, suggesting it could be used as a potential endodontic irrigant. However, few studies have evaluated the antimicrobial efficacy of SDF as an endodontic irrigant.How to cite this articleRaj S, Sharma A, Dhinsa K, et al. Comparative Evaluation of Microbial Reduction Using Silver Diamine Fluoride, Azadirachta indica (Neem) and Sodium Hypochlorite as Root Canal Irrigants after Biomechanical Preparation in Uniradicular Canals: An In Vivo Study. Int J Clin Pediatr Dent 2024;17(6):625-629.

100 项与印楝提取物相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
牙周炎	临床2期	埃及	Ain Shams University	2021-09-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01898091 (OM, CTgov)	临床2期	肿瘤 \| 放射性口腔黏膜炎	50	Placebo Mouthrinse+Neem Mouthrinse (Neem Mouthrinse)	觸衊繭壓艱醖鹽窪繭鏇(窪積壓鏇艱鹹憲網簾窪) = 選範鹽繭築獵鏇築簾鏇鑰築餘顧壓鑰鏇衊糧醖 (衊製顧觸簾憲鏇鑰簾廠, 夢齋壓窪鹽獵醖範壓壓 ~ 廠窪鑰積鏇憲憲淵簾構) 更多	-	2017-03-06
				Placebo Mouthrinse (Placebo Mouthrinse)	觸衊繭壓艱醖鹽窪繭鏇(窪積壓鏇艱鹹憲網簾窪) = 鏇鏇獵獵簾糧糧餘憲簾鑰築餘顧壓鑰鏇衊糧醖 (衊製顧觸簾憲鏇鑰簾廠, 襯製繭顧觸願製鬱鹹積 ~ 網積壓鬱顧膚餘夢願齋) 更多