Organic micropollutants in wastewater containing arsanilic acid (p-ASA) can undergo a transformation into a highly toxic inorganic arsenic, impacting both the environment and human health.Adsorption materials such as Metal-organic frameworks (MOFs) have attracted great interest, yet their production methods are often complex, costly, and time-consuming, hindering large-scale productionWe introduces an innovative, high-throughput microfluidic magnifiable manufacturing approach to expedite MOFs creation, enabling rapid, continuous, and parallel expandable scalable production of MOFs with a uniform microstructure in mere minutes, significantly outpacing the traditional, intermittently operated hydrothermal synthesis.The microfluidic-generated microstructured MF-UIO-66 has better organic arsenic adsorption capacity (333.3 mg/g), and maintained an 89.2% effectiveness even after four cycles of reuse without generating harmful byproducts.When compared to UIO-66 produced via conventional hydrothermal methods, the microfluidically synthesized MF-UIO-66 showcases not only a faster and more effective removal of varying concentrations of organic arsenic but also enhanced chem. stability and longevity.The novel microfluidic fabrication strategy holds great potential for the industrial-scale production of MF-UIO-66 at reduced costs and increased yields.