Chung-Pa-Juhn(Chung-Pa-Juhn) - 药物靶点：MMPs_在研适应症：骨关节炎_专利_临床

概要

基本信息

药物类型

中药

别名

GCSB、Shinbaro

+ [1]

靶点

MMPs

作用机制

MMPs抑制剂(基质金属蛋白酶家族抑制剂)

治疗领域

皮肤和肌肉骨骼疾病

在研适应症

骨关节炎

非在研适应症-

原研机构

Green Cross Holdings Corp.

在研机构

Green Cross Holdings Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

韩国 (2014-04-23),

骨关节炎

最高研发阶段(中国)-

特殊审评-

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关联

3

项与 Chung-Pa-Juhn 相关的临床试验

NCT01910116 / Completed临床2/3期IIT

Treatment Efficacy of 'Shinbaro Capsule' in the Treatment of Hand Osteoarthritis: Randomized, Double-blinded, Placebo-controlled, Multicenter Investigator Initiated Trial.

GCSB-5 ("Shinbaro capsule"), is a mixture of 6 oriental herbs that have anti-inflammatory and analgesic effects along with an excellent safety profile. This study is aimed at investigating efficacy of Shinbaro in the treatment of hand osteoarthritis which needs a long term treatment in a placebo controlled, double-blind randomized trial.

开始日期2013-09-01

申办/合作机构

Seoul National University Hospital

[+1]

NCT01604239 / Completed临床4期

A 24 Weeks, Multi-centers, Single Arm Phase IV Study to Evaluate the Safety of 'Shinbaro Capsule' Compared With Historical Data of 'Celebrex Capsule' in Patients With Osteoarthritis

This study investigates if Shinbaro capsule has a lower incident of gastrointestinal events than celecoxib in subjects with osteoarthritis.

开始日期2012-05-01

申办/合作机构

Green Cross Co., Ltd.

NCT01535417 / Completed临床3期

A 12 Weeks, Randomized, Double-blind, Multi-centers, Phase III Study to Evaluate the Efficacy and Safety of Shinbaro Capsule Compared With Celebrex Capsule in Patients With Osteoarthritis of Knee

The purpose of this study is to evaluate the efficacy and safety of 'Shinbaro Capsule', a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee.

开始日期2009-05-01

申办/合作机构

Green Cross Co., Ltd.

100 项与 Chung-Pa-Juhn 相关的临床结果

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100 项与 Chung-Pa-Juhn 相关的转化医学

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100 项与 Chung-Pa-Juhn 相关的专利（医药）

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17

项与 Chung-Pa-Juhn 相关的文献（医药）

2024-02-01·Current Rheumatology Reviews

Efficacy of Herbal Medicine in Hand Osteoarthritis: A Narrative Review

Review

作者: Noorabadi, Parisa ; Aghili, Seyedeh Mehrnaz ; Sahebari, Maryam ; Salari, Masoumeh

Objective:Osteoarthritis (OA) is one of the most prevalent joint disorders in the world that has placed an enormous economic and social burden on governments and healthcare sectors in many countries. Hand OA (HOA) is the most common peripheral arthritis, which is less investigated than knee and hip OA. Due to limited approved drug choices and adverse effects of long-term use of current regimens, we aimed to review the existing evidence that were used as oral herbal medicine to treat HOA.Methods:The PubMed database was searched for both observational and interventional studies that have investigated herbal medicine safety and efficacy in HOA, written in English and published between 2010 and 2022.Results:A total of 5 original articles fulfilled the inclusion criteria, and each article assessed a different herbal regimen. Overall, it seems desirable to add specific herbal treatments to the regimen of HOA patients, specifically in case of early stages of HOA.Conclusion:Currently, the need for a low-risk alternative treatment in HOA patients is felt more than ever. There are reliable references relating to the safety of Korean red ginseng, GCSB-5, XLGB, and GS-GCu in these patients, although their efficacy was limited. Additionally, herbs like curcumin and Boswellia serrata have positively affected patients with knee osteoarthritis. However, there is a lack of strong evidence supporting their effectiveness in hand osteoarthritis (HOA). This emphasizes the potential benefits that these herbs may have for HOA patients.

2023-12-01·Archives of Rheumatology

GCSB-5 regulates inflammatory arthritis and pain by modulating the mitogen-activated protein kinase signaling pathway in a murine model of rheumatoid arthritis

Article

作者: Bang, Jihye ; Young Park, Soo ; Kim, Sang-Hyon ; Kim, Gyeonghwa ; Kim, Ji-Min ; Jung, Hye Ra

Objectives: This study aimed to determine whether GCSB-5 has anti-inflammatory and antinociceptive effects in mice with collagen-induced arthritis (CIA), an animal model of rheumatoid arthritis (RA), and investigate the influence of GCSB-5 on the mitogen-activated protein kinase (MAPK) pathway.Materials and methods: The experimental animal study was designed to include five groups: CIA mice treated with GCSB-5 (300 mg/kg), GCSB-5 (600 mg/kg), celecoxib (60 mg/kg), or saline for four weeks, and nontreated control mice. The clinical severity of arthritis was scored. Nociceptive thresholds were measured by using a von Frey dynamic plantar analgesimeter. The MAPK pathway was evaluated in mouse synovium. The expression of channels associated with pain signaling was assessed by western blot and immunohistochemical staining.Results: GCSB-5 treatment diminished the severity of clinical arthritis and increased the nociceptive threshold in mice with CIA. Celecoxib, a positive control drug, also showed comparable changes. Clinical arthritis scores were inversely related to mechanical thresholds. GCSB-5 administration decreased the levels of anti-type II collagen antibody and inflammatory cytokines in the sera of mice with CIA. Furthermore, ERK, p38 MAPK, and JNK phosphorylation were downregulated and TRPV1 and ASIC3 expression were decreased in the synovium of GCSB-5-treated mice compared to salinetreated mice. Interleukin-6-induced TRPV1 and ASIC3 upregulation were also inhibited by GCSB-5 in human RA fibroblast-like synoviocytes in vitro.Conclusion: GCSB-5 decreased inflammatory arthritis and pain in a murine model of RA. The results present evidence that GCSB-5 may be beneficial for relieving pain as well as decreasing inflammation in autoimmune arthritis, such as RA.

2023-01-01·Chemosphere

Vitamin C modified crayfish shells biochar efficiently remove tetracycline from water: A good medicine for water restoration

Article

作者: Dai, Yingjie ; Jiang, Huating

In this study, crayfish shell biochar (CSB) was modified by introducing vitamin C (VC) with abundant surface functional groups. CSB was impregnated with VC at different ratios and its capacity to adsorb tetracycline (TC) from water was analyzed. The physicochemical properties of CSB were determined by N₂ adsorption-desorption isotherm analysis, X-ray diffraction, and Fourier transform infrared spectroscopy. The effects of various factors on adsorption such as the pH, TC concentration, time, and salt ion concentrations were also investigated. Based on the chemical structure of VC, VC can provide CSB with more oxygen-containing functional groups such as hydroxyl groups. The results showed that the CSB modified with VC (CSB-VC) exhibited excellent adsorption of TC, and CSB-VC₂ with an impregnation ratio of 2 (gVC/gCSB) had the greatest adsorption performance (saturated adsorption capacity, Q_m = 293.36 mg/g), whereas the adsorption performance of CSB alone was about 50% lower (Q_m = 172.16 mg/g). The optimal impregnation ratio VC improved the adsorption performance of CSB after modification to 70.4% of the original. Hydrogen bonding, p-p conjugation, pi-pi electron donor-acceptor effect, and π-π interactions were identified as the main adsorption mechanisms. CSB-VC₂ was highly effective over a wide range of pH values and at high ion concentrations. Experiments demonstrated the effective regeneration of the adsorbent after multiple cycles, thereby indicating its excellent reusability. It should be noted that the adsorption capacity was good under different water quality conditions, and thus it should exhibit stable adsorption performance under complex water environment conditions.

100 项与 Chung-Pa-Juhn 相关的药物交易

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外链

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研发状态

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适应症	国家/地区	公司	日期
骨关节炎	韩国	Green Cross Holdings Corp.	2014-04-23

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01604239 (Pubmed)	临床4期	骨关节炎	761	GCSB-5	範鬱窪遞構鹽鏇艱網醖(醖餘淵鏇餘遞築積醖餘) = 鹽廠願膚壓醖衊鏇襯觸鑰鹽艱齋顧鏇範糧餘網 (製顧壓鑰膚構壓淵築憲 )	积极	2016-08-02
NCT01910116 (Pubmed \| Med Lett Drugs Ther) 人工标引	临床2/3期	骨关节炎	215	GCSB-5	(壓壓餘製艱糧憲襯獵壓) = 鬱鹹醖簾鏇襯壓夢窪積齋壓鹽廠築積鏇鹽獵夢 (襯網憲襯選壓簾築餘夢 ) 更多	积极	2016-08-01
				Placebo	(壓壓餘製艱糧憲襯獵壓) = 壓網築廠選餘選獵範襯齋壓鹽廠築積鏇鹽獵夢 (襯網憲襯選壓簾築餘夢 ) 更多
NCT01910116 (CTgov)	临床2/3期	骨关节炎	220	Shinbaro (Shinbaro)	衊壓蓋衊憲夢構選糧鹽(襯網選憲鏇繭襯衊網顧) = 憲糧構積醖鬱鑰醖窪範顧繭選鏇壓蓋蓋鑰製顧 (廠顧繭遞繭範選積淵製, 膚築窪簾蓋願範築夢構 ~ 夢膚鬱構艱艱夢獵艱淵) 更多	-	2015-12-17
				Placebo (Placebo)	衊壓蓋衊憲夢構選糧鹽(襯網選憲鏇繭襯衊網顧) = 觸憲獵窪衊鏇簾膚餘廠顧繭選鏇壓蓋蓋鑰製顧 (廠顧繭遞繭範選積淵製, 簾構艱壓遞齋鏇築範夢 ~ 憲襯壓夢網憲鬱鹽顧範) 更多
NCT01910116 (EULAR2015)	临床2/3期	骨关节炎	-	GCSB-5 600 mg	(夢艱憲獵夢鹹蓋鹽窪製) = 廠鹹網願選艱餘廠憲鹽憲衊醖齋衊齋襯築蓋齋 (觸網夢鹽艱糧網製鑰夢, -23.8 ~ -0.2) 更多	积极	2015-06-10
				Placebo	(夢艱憲獵夢鹹蓋鹽窪製) = 廠鑰廠鏇築蓋簾鹽淵鹽憲衊醖齋衊齋襯築蓋齋 (觸網夢鹽艱糧網製鑰夢, -16.7 ~ 6.0) 更多