洋甘菊提取物(Matricaria chamomilla extract) - 药物靶点：Nrf2_在研适应症：应激氧化_专利_临床

概要

基本信息

药物类型

中药

别名

chamomile extract

靶点

Nrf2

作用机制

Nrf2刺激剂(核转录因子的激活红细胞2相关因子刺激剂)

治疗领域

其他疾病

在研适应症

应激氧化

非在研适应症

广泛性焦虑障碍

原研机构

University of Pennsylvania

在研机构

Case Western Reserve University

非在研机构

University of Pennsylvania

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

6

项与洋甘菊提取物相关的临床试验

PACTR202411502237433

/ CompletedN/AIIT

The effects of Lavender ,Chamomile and peppermint inhalation aromatherapy on dental anxiety in children: A randomized controlled trial

开始日期2024-10-15

申办/合作机构-

IRCT20240929063198N1

/ CompletedN/AIIT

The Effect of TRX Training with Chamomile Extract Supplement on Serum Levels of lipocalin 2, Oxidative Stress Factors and Glycemic Indices in Type 2 Diabetic Women

开始日期2024-09-30

申办/合作机构-

IRCT20240611062090N1

/ RecruitingN/AIIT

The evaluation of the topical effect of Chamomile Oil on improving neuropathy symptoms in controlleddiabetic patients attend Shiraz diabetes clinic in 2022 A randomized double-blinded controlled clinical trial

开始日期2024-08-05

申办/合作机构

Shiraz University of Medical Sciences

100 项与洋甘菊提取物相关的临床结果

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100 项与洋甘菊提取物相关的转化医学

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100 项与洋甘菊提取物相关的专利（医药）

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232

项与洋甘菊提取物相关的文献（医药）

2025-02-01·Complementary Therapies in Clinical Practice

Effects of aromatherapy on discomfort in mothers undergoing cesarean section: A systematic review and meta-analysis of randomized controlled trials

Review

作者: Wang, Xiaohan ; Liu, Yurong ; Wang, Zhiping ; Yan, Yanan ; Mao, Jinghe

BACKGROUND AND PURPOSEAromatherapy, a non-pharmacological intervention involving essential oils, has been suggested as a complementary therapy for perioperative discomfort. This study seeks to systematically examine the efficacy of aromatherapy in alleviating pain and other discomforts in mothers undergoing cesarean sections.METHODSA systematic search of PubMed, the Cochrane Library, and Embase was conducted from inception to September 2024. Inclusion criteria involved mothers undergoing cesarean section, aromatherapy as an intervention, and outcomes such as pain, anxiety, nausea and vomiting. Subgroup analyses explored the effects of distinct control groups, essential oil, dosage, number of sessions, and session length of aroma preparations. Statistical analysis was conducted using RevMan 5.3, with heterogeneity assessed using the Q test and I² statistic.RESULTSSeventeen studies involving 1490 participants were included. Aromatherapy significantly reduced post-cesarean pain (SMD = -1.19, 95 % CI [-1.93, -0.45], p = 0.002). Chamomile oil, low dosage (≤2 drops), single session and sessions lasting 20 min or less were more effective in relieving pain. Aromatherapy significantly decreased nausea incidence (RR = 0.52, 95 % CI [0.33, 0.81], p = 0.004), reduced analgesic requirements (RR = 0.60, 95 % CI [0.49, 0.73], p < 0.00001), and improved patient satisfaction (RR = 1.64, 95 % CI [1.26, 2.12], p = 0.0002).CONCLUSIONAromatherapy effectively reduces post-cesarean pain, nausea, analgesic use, and improves patient satisfaction. Chamomile oil, low doses (≤2 drops), single session and short length (≤20 min) seems to be the most effective method for alleviating post-cesarean pain.

2024-11-01·Iranian Journal of Nursing and Midwifery Research

The Effects of Chamomile and Flaxseed on Pelvic Pain, Dyspareunia, and Dysmenorrhea in Endometriosis: A Controlled Randomized Clinical Trial

Article

作者: Khalajinia, Zohre ; Falahieh, Fatemeh Mohanazadeh ; Aghaali, Mohammad

Background:Chamomile and flaxseed are traditionally used medicinal plants to treat painful menstruation. Therefore, this study aimed to investigate the effects of chamomile and flaxseed on pelvic pain, dyspareunia, and dysmenorrhea in endometriosis patients.Materials and Methods:A controlled randomized clinical trial was conducted on 102 endometriosis patients referred to Reyhane Infertility Center of Qom University of Medical Sciences, Iran, from July 2021 to March 2022. Patients were divided into three groups: chamomile, flaxseed, and placebo, using the block randomization method. Patients used 1000 mg capsules (three times a day) for 8 weeks. A Visual Analog Scale (VAS) was used to measure the severity of pain. Pelvic pain, dyspareunia, and dysmenorrhea were assessed on three occasions Data were analyzed using the Chi-square, repeated measures ANCOVA, and ANOVA. All statistical analysis was performed using SPSS version 20.Results:Before the intervention, there was no significant difference between the three groups regarding dysmenorrhea, pelvic pain, or dyspareunia (p > 0.05). The mean score of pelvic pain (on one and two-month follow-ups) in the chamomile and flaxseed groups (F = 383.07, p < 0.001) was lower than that in the placebo group. The mean score of dyspareunia (on one and two-month follow-ups) in the chamomile and flaxseed groups was significantly lower than that in the placebo group (F2 = 479.34, p < 0.001). The mean score of dysmenorrhea on one and two-month follow-ups (F2 = 385.67, p < 0.001) in the chamomile and flaxseed groups was lower than that in the placebo group.Conclusions:Chamomile and flaxseed may reduce pelvic pain, dyspareunia, and dysmenorrhea associated with endometriosis.

2024-10-17·Molecules (Basel, Switzerland)

Optimization of the Cold Water Extraction Method for High-Value Bioactive Compounds from Chamomile (Matricaria chamomilla L.) Flower Heads Through Chemometrics.

Article

作者: Scappaticci, Claudia ; D'Archivio, Angelo Antonio ; Luciani, Ilaria ; Foschi, Martina ; Ruggieri, Fabrizio ; Biancolillo, Alessandra ; Gornati, Giulia ; Marsili, Lorenzo

This study focused on optimizing a cold water extraction method to obtain bioactive compounds from chamomile (Matricaria chamomilla L.), addressing increasing consumer demand for natural products and nutraceuticals. A full-factorial design was employed to evaluate the effects of temperature, time, and chamomile amount on the polyphenolic profile of extracts. The samples were characterized by HPLC-DAD and UV-Vis coupled with chemometrics; the analysis showed that extraction time negatively affected extract quality, as did the interaction between time and temperature. In addition, a significant positive quadratic effect for temperature and a positive coefficient for chamomile amount was found. ASCA was used to assess the UV-Vis profile, offering an alternative untargeted method for understanding the variable effects. The optimal extraction conditions (25 °C, 32 min, and 2.5 g of chamomile) produced samples high in hydroxybenzoic and hydroxycinnamic acids and flavanol derivatives. Using A face-centered design, this study also monitored antioxidant activity via a DPPH scavenging assay, confirming that the optimal conditions yielded samples within the range of maximum antioxidant activity in the studied experimental domain.

100 项与洋甘菊提取物相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
应激氧化	临床前	美国	Case Western Reserve University	2010-04-15
广泛性焦虑障碍	药物发现	美国	University of Pennsylvania	2010-02-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


UEGW2023	N/A	胃食管反流	-	Aligastril gel (alginate+melatonin+chamomile)	願蓋鏇膚醖構鏇壓醖觸(鬱鏇窪壓鑰糧鏇選選簾) = 夢選壓築製鑰顧顧蓋願醖憲蓋範鹹鑰餘簾齋繭 (夢艱鑰遞顧獵遞憲鑰糧 )	-	2023-10-15
				Different PPI	願蓋鏇膚醖構鏇壓醖觸(鬱鏇窪壓鑰糧鏇選選簾) = 願鏇夢艱衊夢齋餘廠選醖憲蓋範鹹鑰餘簾齋繭 (夢艱鑰遞顧獵遞憲鑰糧 )
Pubmed \| Oral Dis	N/A	化疗性口腔黏膜炎	45	topical chamomile (Conventional symptomatic treatment)	齋範獵鹽鏇鹽窪繭衊鹽(餘糧窪觸襯遞廠艱範鏇) = 鏇積觸鏇鹹觸選繭網壓製衊遞襯選廠憲餘衊構 (範願顧顧齋廠糧顧構鹽 )	积极	2022-01-01
				3% chamomile topical oral gel	齋範獵鹽鏇鹽窪繭衊鹽(餘糧窪觸襯遞廠艱範鏇) = 繭鹹構獵範蓋顧齋製窪製衊遞襯選廠憲餘衊構 (範願顧顧齋廠糧顧構鹽 )
NCT01072344 (CTgov)	临床3期	焦虑症 \| 广泛性焦虑障碍	180	Chamomile (Matricaria recutita) (Chamomile Extract)	範醖齋齋廠襯襯繭淵選(壓製壓餘憲鏇鹹夢窪遞) = 選齋願夢憲製蓋壓餘淵願鏇襯廠鹹鹽觸淵願衊 (獵簾製糧積願鬱獵遞蓋, 獵憲餘廠構範膚艱鏇選 ~ 夢壓鬱鏇顧鹽艱網糧遞) 更多	-	2017-07-06
				Chamomile (Matricaria recutita) (Placebo)	範醖齋齋廠襯襯繭淵選(壓製壓餘憲鏇鹹夢窪遞) = 簾範鏇鹹襯選壓願糧遞願鏇襯廠鹹鹽觸淵願衊 (獵簾製糧積願鬱獵遞蓋, 糧願積憲範積壓製壓齋 ~ 餘艱鹹壓餘鏇夢醖築網) 更多