OLX-702A

SUWON, South Korea--(BUSINESS WIRE)-- OliX Pharmaceuticals, Inc. (KOSDAQ: 226950), a leading developer of RNAi therapeutics, today announced that the Company has received approval from the Alfred Human Research Ethics Committee (HREC) to conduct a Phase 1 clinical trial of drug candidate OLX75016 (the candidate of OLX702A) for the treatment of non-alcohol steatohepatitis (NASH). This randomized, double-blind, placebo-controlled, single and multiple ascending dose study will assess the safety and tolerability of OLX75016 in healthy volunteers. OliX Pharmaceuticals is developing OLX75016 as a novel therapeutic in treating NASH accompanied by liver fibrosis and managing weight. The Company has secured positive results from a preclinical non-human primates (NHP) study on the efficacy of OLX75016. OLX75016 administered together with a glucagon-like peptide-1 (GLP-1) receptor agonist (semaglutide) demonstrated additional weight-loss effects, mitigated the weight-rebound effect shown upon termination of semaglutide, lowered total body fat mass, and reduced abdominal girth. According to the Company, these favorable effects were not mediated by changes in food intake. This suggests that not dietary changes or changes in appetite regulation, but beneficial effects on energy expenditure mediate the weight-loss effects of this combination treatment. About OliX Pharmaceuticals OliX Pharmaceuticals is a clinical-stage pharmaceutical company developing therapeutics against a variety of disorders by down-regulating the expression of disease-causing genes based on its own proprietary RNAi technology. The Company’s core RNAi platform, asymmetric siRNA (asiRNA), is a unique gene silencing technology based on RNA interference (RNAi), which is considered the most efficient gene silencing technology. Utilizing this proprietary asiRNA technology, OliX has developed cell penetrating asiRNA (cp-asiRNA), a therapeutic RNAi platform to effectively target diseases including hypertrophic scarring, dry and wet age-related macular degeneration (AMD), and subretinal fibrosis. OliX has also developed another therapeutic RNAi platform, GalNAc-asiRNA, to target a variety of liver diseases. Learn more:

SUWON, South Korea--(BUSINESS WIRE)-- OliX Pharmaceuticals, Inc. (KOSDAQ: 226950), a leading developer of RNAi therapeutics, today announced that the Company presented its latest study data from preclinical studies identifying synergistic effects in weight loss when using its non-alcoholic steatohepatitis (NASH) treatment candidate OLX702A in combination with semaglutide. The data was presented at TIDES USA 2023, an international conference dedicated to oligonucleotide and peptide therapeutics, held in San Diego, California, on May 7-10. During the conference’s poster session, OliX revealed preclinical study results of OLX702A, addressing key mechanisms involved in NASH and obesity. The Company’s NASH with fibrosis / Obesity program derives from a robust target discovered from a genome-wide association study (GWAS), a research approach to identifying genomic variants involving a large group of people. According to the OliX’s presentation, the Company had seen synergistic effects when OLX702A was administered in combination with semaglutide, an anti-obesity drug imitating glucagon-like peptide 1 (GLP-1), a hormone that helps people feel satiated. The combination data demonstrated an additional 10% reduction in weight compared to administering semaglutide alone. Metabolic analysis suggests that the weight loss caused by OLX702A treatment is due to the increase in energy expenditure, which is distinct from incretin-based anti-obesity drugs like semaglutide. In addition, the Company presented data showing the efficacy of reversing liver fibrosis and inducing the reduction of liver fat content. “Through various preclinical studies, OLX702A was found to have significant effects not only in treating NASH accompanied by liver fibrosis but also in reducing weight,” said an OliX Pharmaceuticals official. “In particular, we can expect the high potential of OLX702A as a novel treatment in treating multiple metabolic diseases as it works distinctively from semaglutide. We look forward to seeing more efficacy in forthcoming combination studies.” About OliX Pharmaceuticals OliX Pharmaceuticals is a clinical-stage pharmaceutical company developing therapeutics against a variety of disorders by down-regulating the expression of disease-causing genes based on its own proprietary RNAi technology. Utilizing this proprietary asiRNA technology, OliX has developed cell penetrating asiRNA (cp-asiRNA), a therapeutic RNAi platform to effectively target diseases including hypertrophic scarring, dry and wet age-related macular degeneration (AMD), and subretinal fibrosis. OliX has also developed another therapeutic RNAi platform, GalNAc-asiRNA, to target a variety of liver diseases. Learn more: